One-Year Effects of Project EX in Spain: A Classroom-Based Smoking Prevention and Cessation Intervention Program.

BackgroundTobacco use prevalence rates are high among Spanish adolescents. Programming to counteract tobacco use is needed.Methods and findingsThe current study provides a one-year follow-up outcome evaluation of Project EX, an eight-session classroom-based curriculum. The intervention was tested using a randomized controlled trial with 1,546 Spanish students, involving three program and three control schools. Compared to the control condition, the program condition revealed a greater reduction in nicotine dependence (p < .05) and CO ppm levels (p < .001), and lower consumption of cigarettes at last month (p = .03).ConclusionsLong-term outcomes of the Project EX classroom-based program are promising for adolescent prevention and possibly cessation in Spain

Spatially-resolved Radio-to-Far-infrared SED of the Luminous Merger Remnant NGC 1614 with ALMA and VLA

We present the results of Atacama Large Millimeter/Submillimeter Array (ALMA) 108, 233, 352, and 691 GHz continuum observations and Very Large Array (VLA) 4.81 and 8.36 GHz observations of the nearby luminous merger remnant NGC 1614. By analyzing the beam (1".0 * 1".0) and uv (> 45 k{\lambda}) matched ALMA and VLA maps, we find that the deconvolved source size of lower frequency emission (< 108 GHz) is more compact (420 pc * 380 pc) compared to the higher frequency emission (> 233 GHz) (560 pc * 390 pc), suggesting different physical origins for the continuum emission. Based on an SED model for a dusty starburst galaxy, it is found that the SED can be explained by three components, (1) non-thermal synchrotron emission (traced in the 4.81 and 8.36 GHz continuum), (2) thermal free-free emission (traced in the 108 GHz continuum), and (3) thermal dust emission (traced in the 352 and 691 GHz continuum). We also present the spatially-resolved (sub-kpc scale) Kennicutt-Schmidt relation of NGC 1614. The result suggests a systematically shorter molecular gas depletion time in NGC 1614 (average {\tau}_gas of 49 - 77 Myr and 70 - 226 Myr at the starburst ring and the outer region, respectively) than that of normal disk galaxies (~ 2 Gyr) and a mid-stage merger VV 114 (= 0.1 - 1 Gyr). This implies that the star formation activities in U/LIRGs are efficiently enhanced as the merger stage proceeds, which is consistent with the results from high-resolution numerical merger simulations.Comment: 10 pages, 6 figures, accepted for publication in PAS

In vivo tracking and immunological properties of pulsed porcine monocyte-derived dendritic cells

Cellular therapies using immune cells and in particular dendritic cells (DCs) are being increasingly applied in clinical trials and vaccines. Their success partially depends on accurate delivery of cells to target organs or migration to lymph nodes. Delivery and subsequent migration of cells to regional lymph nodes is essential for effective stimulation of the immune system. Thus, the design of an optimal DC therapy would be improved by optimizing technologies for monitoring DC trafficking. Magnetic resonance imaging (MRI) represents a powerful tool for non-invasive imaging of DC migration in vivo. Domestic pigs share similarities with humans and represent an excellent animal model for immunological studies. The aim of this study was to investigate the possibility using pigs as models for DC tracking in vivo. Porcine monocyte derived DC (MoDC) culture with superparamagnetic iron oxide (SPIO) particles was standardized on the basis of SPIO concentration and culture viability. Phenotype, cytokine production and mixed lymphocyte reaction assay confirmed that porcine SPIO-MoDC culture were similar to mock MoDCs and fully functional in vivo. Alike, similar patterns were obtained in human MoDCs. After subcutaneous inoculation in pigs, porcine SPIO-MoDC migration to regional lymph nodes was detected by MRI and confirmed by Perls staining of draining lymph nodes. Moreover, after one dose of virus-like particles-pulsed MoDCs specific local and systemic responses were confirmed using ELISPOT IFN-γ in pigs. In summary, the results in this work showed that after one single subcutaneous dose of pulsed MoDCs, pigs were able to elicit specific local and systemic immune responses. Additionally, the dynamic imaging of MRI-based DC tracking was shown using SPIO particles. This proof-of-principle study shows the potential of using pigs as a suitable animal model to test DC trafficking with the aim of improving cellular therapies.We want to thank: Ferrán López, Rosa López, Zoraida Cervera, Pamela Martinez-Orellana, Tufaria Mussá, Massimiliano Baratelli, Diego Pérez, Sergio López from CRESA and José Luis Ruiz de la Torre and Javier Aceña (UAB) for farm and technical support; Jaume Martorell (Fundació Hospital Clínic Veterinari, UAB) for MRI support; Javier Domínguez (INIA) for the porcine antibodies; Antonio Lestuzzi, Michele Crisci and Raif Yucel for MR imaging support; Joaquim Segalés for anatomic pathology analysis; Mónica Pérez for immunohistochemical stainings; Aida Neira and Blanca Pérez for Perls staining; Eva Huerta y Marina Sibila for PCV2 PCR; David Andreu and Beatriz García de la Torre (Pompeu Fabra University, Barcelona), and Esther Blanco (CISA-INIA, Madrid), for the FMDV 3A peptide; Alicia Solórzano for critically reviewing the manuscript. This work was funded by the project AGL2010-22200-C02 of Spanish Ministry of Science and Innovation. PhD studies of Raquel Cabezón are funded by a doctoral FI fellowship from the Generalitat de Catalunya

Regarding Pilot Usage of Display Technologies for Improving Awareness of Aircraft System States

ed systems and the procedures for ng in complexity. This interacting trend places a larger burden on pilots to manage increasing amounts of information and to understand system interactions. The result is an increase in the likelihood of loss of airplane state awareness (ASA). One way to gain more insight into this issue is through experimentation using objective measures of visual behavior. This study summarizes an analysis of oculometer data obtained during a high-fidelity flight simulation study that included a variety of complex pilot-system interactions that occur in current flight decks, as well as several planned for the next generation air transportation system. The study was comprised of various scenarios designed to induce low and high energy aircraft states coupled with other emulated causal factors in recent accidents. Three different display technologies were evaluated in this recent pilot-in-the-loop study conducted at NASA Langley Research Center. These technologies include a stall recovery guidance algorithm and display concept, an enhanced airspeed control indication of when the automation is no longer actively controlling airspeed, and enhanced synoptic diagrams with corresponding simplified electronic interactive checklists. Multiple data analyses were performed to understand how the 26 participating airline pilots were observing ASA-related information provided during different stag specific events within these stages

ALMA Observations of the Physical and Chemical Conditions in Centaurus A

Centaurus A, with its gas-rich elliptical host galaxy, NGC 5128, is the nearest radio galaxy at a distance of 3.8 Mpc. Its proximity allows us to study the interaction between an active galactic nucleus, radio jets, and molecular gas in great detail. We present ALMA observations of low J transitions of three CO isotopologues, HCN, HCO$^{+}$, HNC, CN, and CCH toward the inner projected 500 pc of NGC 5128. Our observations resolve physical sizes down to 40 pc. By observing multiple chemical probes, we determine the physical and chemical conditions of the nuclear interstellar medium of NGC 5128. This region contains molecular arms associated with the dust lanes and a circumnuclear disk (CND) interior to the molecular arms. The CND is approximately 400 pc by 200 pc and appears to be chemically distinct from the molecular arms. It is dominated by dense gas tracers while the molecular arms are dominated by $^{12}$CO and its rare isotopologues. The CND has a higher temperature, elevated CN/HCN and HCN/HNC intensity ratios, and much weaker $^{13}$CO and C$^{18}$O emission than the molecular arms. This suggests an influence from the AGN on the CND molecular gas. There is also absorption against the AGN with a low velocity complex near the systemic velocity and a high velocity complex shifted by about 60 km s$^{-1}$. We find similar chemical properties between the CND in emission and both the low and high velocity absorption complexes implying that both likely originate from the CND. If the HV complex does originate in the CND, then that gas would correspond to gas falling toward the supermassive black hole

Local instability signatures in ALMA observations of dense gas in NGC7469

We present an unprecedented measurement of the disc stability and local instability scales in the luminous infrared Seyfert 1 host, NGC7469, based on ALMA observations of dense gas tracers and with a synthesized beam of 165 x 132 pc. While we confirm that non-circular motions are not significant in redistributing the dense interstellar gas in this galaxy, we find compelling evidence that the dense gas is a suitable tracer for studying the origin of its intensely high-mass star forming ring-like structure. Our derived disc stability parameter accounts for a thick disc structure and its value falls below unity at the radii in which intense star formation is found. Furthermore, we derive the characteristic instability scale and find a striking agreement between our measured scale of ~ 180 pc, and the typical sizes of individual complexes of young and massive star clusters seen in high-resolution images.Comment: Accepted for publication in ApJ Letter