France and the Community of Six: The Schuman Declaration to the Treaties of Rome

This paper investigates France’s role during the first decade of European integration, and in particular the initiatives of Jean Monnet and Robert Schuman which led to the creation of the European Communities. Monnet and Schuman began the modern process of uniting Europe with the creation of the European Coal and Steel Community, but the process of integration faced its strongest opposition within France itself and the movement had its first setback in 1954 when the French National Assembly rejected the proposed European Defense Community. Nevertheless, European integration continued, and after the subsequent French election, France rebuilt momentum for further European integration and led the effort to create the European Economic Community and the European Atomic Energy Community. Both of these Communities came into existence in 1958 and – along with the European Coal and Steel Community – laid the institutional foundation for the European Union

Persistence of porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 in bacterial biofilms

The aim of this pilot project was to investigate association of viruses with bacterial biofilms. Our preliminary data indicate that important viral pathogens of swine, namely, porcine reproductive and respiratory syndrome virus and porcine circovirus type 2, can associate with and persist within bacterial biofilms for several days

Physico-chemical characteristics and methanogen communities in swine and dairy manure storage tanks: Spatio-temporal variations and impact on methanogenic activity

Greenhouse gas emissions represent a major environmental problem associated with the management of manure from the livestock industry. Methane is the primary GHG emitted during manure outdoor storage. In this paper, the variability of two swine and two dairy manure storage tanks was surveyed, in terms of physico-chemical and microbiological parameters. The impact of the inter-tank and spatio-temporal variations of these parameters on the methanogenic activity of manure was ascertained. A Partial Least Square regression was carried out, which demonstrated that physico-chemical as well as microbiological parameters had a major influence on the methanogenic activity. Among the 19 parameters included in the regression, the concentrations of VFAs had the strongest negative influence on the methane emission rate of manure, resulting from their well-known inhibitory effect. The relative abundance of two amplicons in archaeal fingerprints was found to positively influence the methanogenic activity, suggesting that Methanoculleus spp. and possibly Methanosarcina spp. are major contributors to methanogenesis in storage tanks. This work gave insights into the mechanisms, which drive methanogenesis in swine and dairy manure storage tanks

Transcriptional approach to study porcine tracheal epithelial cells individually or dually infected with swine influenza virus and Streptococcus suis

Background: Swine influenza is a highly contagious viral infection in pigs affecting the respiratory tract that can have significant economic impacts. Streptococcus suis serotype 2 is one of the most important post-weaning bacterial pathogens in swine causing different infections, including pneumonia. Both pathogens are important contributors to the porcine respiratory disease complex. Outbreaks of swine influenza virus with a significant level of co-infections due to S. suis have lately been reported. In order to analyze, for the first time, the transcriptional host response of swine tracheal epithelial (NPTr) cells to H1N1 swine influenza virus (swH1N1) infection, S. suis serotype 2 infection and a dual infection, we carried out a comprehensive gene expression profiling using a microarray approach. Results: Gene clustering showed that the swH1N1 and swH1N1/S. suis infections modified the expression of genes in a similar manner. Additionally, infection of NPTr cells by S. suis alone resulted in fewer differentially expressed genes compared to mock-infected cells. However, some important genes coding for inflammatory mediators such as chemokines, interleukins, cell adhesion molecules, and eicosanoids were significantly upregulated in the presence of both pathogens compared to infection with each pathogen individually. This synergy may be the consequence, at least in part, of an increased bacterial adhesion/invasion of epithelial cells previously infected by swH1N1, as recently reported. Conclusion: Influenza virus would replicate in the respiratory epithelium and induce an inflammatory infiltrate comprised of mononuclear cells and neutrophils. In a co-infection situation, although these cells would be unable to phagocyte and kill S. suis, they are highly activated by this pathogen. S. suis is not considered a primary pulmonary pathogen, but an exacerbated production of proinflammatory mediators during a co-infection with influenza virus may be important in the pathogenesis and clinical outcome of S. suis-induced respiratory diseases

Perceptions of Blended Learning: A Case Study on Student Experiences in an Advanced Placement Macroeconomics Course

The purpose of this study was to use a case study design to examine the impact of a blended learning instructional model on students in an Advanced Placement (AP) Macroeconomics course. Using an instrumental case study design, the researcher investigated blended learning and students’ perceptions of their own interactions with the materials as well as perceptions of overall performance in the course. The study also used grade point averages (GPA), LMS Usage Reports, and AP exam scores to triangulate with the interview data. The key factors influencing the students’ views were discussed, an enhanced model of blended learning was proposed, recommendations for future research were made, and strategies and practices were offered

Monnet, the General, and the Community of Six: French Policy on European Integration in the 1950s and 1960s

This thesis examines the roles of Jean Monnet and General Charles de Gaulle in crafting French policy towards a united Europe during the postwar decades. Monnet strongly supported supranational integration in which the nations of Europe cede power to common governing institutions. But, French policy changed dramatically when de Gaulle came to power in 1958. As a nationalist he refused to sacrifice France’s independence by ceding power to the common institutions. He risked the existence of a united Europe, but after his sudden departure in 1969 it became clear that French popular opinion opposed his limiting policy towards European integration

Pathogenesis of hyperinflation in chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a preventable and treatable lung disease characterized by airflow limitation that is not fully reversible. In a significant proportion of patients with COPD, reduced lung elastic recoil combined with expiratory flow limitation leads to lung hyperinflation during the course of the disease. Development of hyperinflation during the course of COPD is insidious. Dynamic hyperinflation is highly prevalent in the advanced stages of COPD, and new evidence suggests that it also occurs in many patients with mild disease, independently of the presence of resting hyperinflation. Hyperinflation is clinically relevant for patients with COPD mainly because it contributes to dyspnea, exercise intolerance, skeletal muscle limitations, morbidity, and reduced physical activity levels associated with the disease. Various pharmacological and nonpharmacological interventions have been shown to reduce hyperinflation and delay the onset of ventilatory limitation in patients with COPD. The aim of this review is to address the more recent literature regarding the pathogenesis, assessment, and management of both static and dynamic lung hyperinflation in patients with COPD. We also address the influence of biological sex and obesity and new developments in our understanding of hyperinflation in patients with mild COPD and its evolution during progression of the disease

Algeria, De Gaulle, and the Birth of the French Fifth Republic

This paper explores the role of the French Army and the role of General Charles de Gaulle in the Crisis of May 1958, and how the Crisis marked the end of the French Fourth Republic. The role of civilians in starting the uprising in Algeria is highlighted, and it is emphasized that the French Army joined the revolt once it was in progress. Although General de Gaulle had been out of public life for a decade, it was he who came to power because of the Crisis and it was he who went on to create the new French Fifth Republic. This paper was selected as the winner of the first annual Providence College Undergraduate Research Prize in 201