Hepatoid carcinoma of the ovary: A case report and review of the literature

Primary hepatoid carcinoma of the ovary (HCO) is a rare aggressive tumor that typically presents at an advanced stage in postmenopausal women with unilateral or bilateral ovarian masses and elevated AFP and CA125. We report a case of HCO in a 73 year-old woman who presented with abdominal distention, weight loss, and a large lower abdominal mass. Postoperative serum AFP was markedly elevated and trended down with initiation of chemotherapy. Review of the literature revealed thirty-two reported cases with no consensus on histogenesis or consistent immunohistochemical profile other than positive AFP staining in all but one case. Although the optimal treatment has not yet been determined, tumor debulking surgery followed by a platinum and taxane based chemotherapy regimen has shown promise. Both serum AFP and CA125 appear to have prognostic value and can be used to follow response to treatment and screen for recurrence

Concurrent renal-cell carcinoma and cutaneous leiomyomas: A case of HLRCC

AbstractA 51-year-old Caucasian female presenting with renal-cell cancer and cutaneous leiomyomas was later diagnosed with Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) Syndrome. HLRCC is an autosomal dominant condition caused by a mutation in the fumarate hydratase gene, which encodes for an enzyme in the citric acid cycle. This syndrome has been reported in over 100 families throughout the world, the majority of whom are of Eastern European descent. Those with this syndrome have a significantly increased risk of developing renal-cell carcinoma, cutaneous leiomyomas, and uterine leiomyomas, and a smaller chance of developing uterine leiomyosarcomas. This syndrome has a relatively poor prognosis, with tumor metastasis occurring in approximately 50% of patients. However, more aggressive prophylactic measures and recent studies have shown potential to improve patient prognosis

Concurrent renal-cell carcinoma and cutaneous leiomyomas: A case of HLRCC

A 51-year-old Caucasian female presenting with renal-cell cancer and cutaneous leiomyomas was later diagnosed with Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) Syndrome. HLRCC is an autosomal dominant condition caused by a mutation in the fumarate hydratase gene, which encodes for an enzyme in the citric acid cycle. This syndrome has been reported in over 100 families throughout the world, the majority of whom are of Eastern European descent. Those with this syndrome have a significantly increased risk of developing renal-cell carcinoma, cutaneous leiomyomas, and uterine leiomyomas, and a smaller chance of developing uterine leiomyosarcomas. This syndrome has a relatively poor prognosis, with tumor metastasis occurring in approximately 50% of patients. However, more aggressive prophylactic measures and recent studies have shown potential to improve patient prognosis

Counting the Pinocchios: The effect of summary fact-checking data on perceived accuracy and favorability of politicians

Can the media effectively hold politicians accountable for making false claims? Journalistic fact-checking assesses the accuracy of individual public statements by public officials, but less is known about whether this process effectively imposes reputational costs on misinformation-prone politicians who repeatedly make false claims. This study therefore explores the effects of exposure to summaries of fact-check ratings, a new format that presents a more comprehensive assessment of politician statement accuracy over time. Across three survey experiments, we compared the effects of negative individual statement ratings and summary fact-checking data on favorability and perceived statement accuracy of two prominent elected officials. As predicted, summary fact-checking had a greater effect on politician perceptions than individual fact-checking. Notably, we did not observe the expected pattern of motivated reasoning: co-partisans were not consistently more resistant than supporters of the opposition party. Our findings suggest that summary fact-checking is particularly effective at holding politicians accountable for misstatements. </jats:p

Replication Data for: "Counting the Pinocchios: The Effect of Summary Fact-Checking Data on Perceived Accuracy and Favorability of Politicians"

Replication materials include the Stata do file, three .dta files for each study in the paper, and a PDF file describing each file and how to carry out the replication