A ditadura militar em londrina desenvolvida por meio de aula oficina

Anais do II Seminário Seminário Estadual PIBID do Paraná: tecendo saberes / organizado por Dulcyene Maria Ribeiro e Catarina Costa Fernandes — Foz do Iguaçu: Unioeste; Unila, 2014O presente trabalho aborda a metodologia da Aula Oficina, com o uso de evidências, como possibilidade de intervenção em aulas de história no ensino fundamental, a partir dos pressupostos teóricos do Ensino de História no campo da Educação Histórica conforme Isabel Barca (2004). O processo de construção das aulas contou com vários encontros entre professores coordenadores, professores supervisores e graduandos do Pibid- História -UEL, observação e intervenção em sala de aula do Colégio Estadual Tsuru Oguido, Londrina-Paraná. Verifica-se que a Aula Oficina possibilita ao professor uma maior interação e dinamiza a abordagem dos conceitos substantivos e de segunda ordem visando à formação da consciência histórica dos jovens em idade de escolarização a partir da cognição histórica situad

Quaternion-based deep belief networks fine-tuning

Deep learning techniques have been paramount in the last years, mainly due to their outstanding results in a number of applications. In this paper, we address the issue of fine-tuning parameters of Deep Belief Networks by means of meta-heuristics in which real-valued decision variables are described by quaternions. Such approaches essentially perform optimization in fitness landscapes that are mapped to a different representation based on hypercomplex numbers that may generate smoother surfaces. We therefore can map the optimization process onto a new space representation that is more suitable to learning parameters. Also, we proposed two approaches based on Harmony Search and quaternions that outperform the state-of-the-art results obtained so far in three public datasets for the reconstruction of binary images

Pemphigus is associated with KIR3DL2 expression levels and provides evidence that KIR3DL2 may bind HLA-A3 and A11 in vivo.

This is the peer reviewed version of the following article:Augusto, D. G., O'Connor, G. M., Lobo-Alves, S. C., Bass, S., Martin, M. P., Carrington, M., . . . Petzl-Erler, M. L. (2015). Pemphigus is associated with KIR3DL2 expression levels and provides evidence that KIR3DL2 may bind HLA-A3 and A11 in vivo. European Journal of Immunology, 45(7), 2052-2060, which has been published in final form at DOI: 10.1002/eji.201445324. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-ArchivingAlthough HLA-A3 and A11 have been reported to be ligands for KIR3DL2, evidence for any in vivo relevance of this interaction is still missing. To explore the functional importance of KIR3DL2 allelic variation, we analyzed the autoimmune disease pemphigus foliaceus, previously associated (lower risk) with activating KIR genes. KIR3DL2*001 was increased in patients (odds ratio (OR) = 2.04; p = 0.007). The risk was higher for the presence of both KIR3DL2*001 and HLA-A3 or A11 (OR = 3.76, p = 0.013), providing the first evidence that HLA-A3 and A11 may interact with KIR3DL2 in vivo. The nonsynonymous single nucleotide polymorphism 1190T (rs3745902) was associated with protection (OR = 0.52, p = 0.018). This SNP results in a threonine-to-methionine substitution. Individuals who have methionine in this position exhibit a lower percentage of KIR3DL2-positive natural killer (NK) cells and also lower intensity of KIR3DL2 on expressing natural killer cells; additionally, we show that the expression of KIR3DL2 is independent of other killer cell immunoglobulin-like receptors. Pemphigus foliaceus is a very unique complex disease strongly associated with immune-related genes. It is the only autoimmune disease known to be endemic, showing a strong correlation with environmental factors. Our data demonstrate that this relatively unknown autoimmune disease may facilitate understanding of the molecular mechanisms of KIR3DL2 ligand recognition

Quando a integridade eleitoral está em risco: democracia, fraude e instituições na América Latina

How do the characteristics of Electoral Management Bodies (EMBs) affect electoral fraud? This study investigates how the institutional design of EMBs influences the occurrence of electoral fraud and explores the relationship between different EMB characteristics and various types of fraud. Recent literature underscores the significance of EMB autonomy from public administration and effective institutional design. Utilizing the Electoral Integrity Project (EIP) database, the research examines elections in Latin American countries. The study finds that EMB autonomy and institutional capacity have a significant impact on electoral integrity. Moreover, the presence of electoral observers is linked to a reduction in fraud. By establishing a descriptive association between the independent variable (EMB) and the dependent variable (Fraud), and including variables related to the participation of electoral observers, the study identifies patterns in these relationships within Latin America. These findings suggest that enhancing EMB autonomy and capacity can improve electoral integrity, offering valuable insights for electoral management reforms.¿Cómo afectan las características de los Electoral Management Bodies (EMB) al fraude electoral? Este estudio investiga cómo el diseño institucional de los EMB influye en la ocurrencia de fraudes electorales y explora la relación entre diferentes características de los EMB y varios tipos de fraude. La literatura reciente destaca la importancia de la autonomía de los EMB respecto de la administración pública y el diseño institucional eficaz. Utilizando la base de datos del Electoral Integrity Project (EIP), la investigación examina elecciones en países de América Latina. El estudio encuentra que la autonomía y la capacidad institucional de los EMB tienen un impacto significativo en la integridad electoral. Además, la presencia de observadores electorales está vinculada a una reducción del fraude. Al establecer una asociación descriptiva entre la variable independiente (EMB) y la variable dependiente (fraude), e incluir variables relacionadas con la participación de observadores electorales, el estudio identifica patrones en estas relaciones dentro de América Latina. Estos hallazgos sugieren que mejorar la autonomía y la capacidad de los EMB puede mejorar la integridad electoral, ofreciendo información valiosa para las reformas de gestión electoral.Como as características dos Electoral Management Bodies (EMBs) afetam a fraude eleitoral? Este estudo investiga como o desenho institucional dos EMBs influencia a ocorrência de fraudes eleitorais e explora a relação entre diferentes características dos EMBs e vários tipos de fraude. A literatura recente destaca a importância da autonomia dos EMBs em relação à administração pública e o desenho institucional eficaz. Utilizando o banco de dados do Electoral Integrity Project (EIP), a pesquisa examina eleições em países da América Latina. O estudo encontra que a autonomia e a capacidade institucional dos EMBs têm um impacto significativo na integridade eleitoral. Além disso, a presença de observadores eleitorais está associada a uma redução na fraude. Ao estabelecer uma associação descritiva entre a variável independente (EMBs) e a variável dependente (Fraude), e incluir variáveis relacionadas à participação de observadores eleitorais, o estudo identifica padrões nessas relações na América Latina. Esses achados sugerem que melhorar a autonomia e a capacidade dos EMBs pode aumentar a integridade eleitoral, oferecendo insights valiosos para reformas na gestão eleitoral

Major approaches to melatonin and nutrients regulation in the bone regeneration process with exosomes and microRNAs: a systematic review

Introduction: Bone diseases comprise a large group of common diseases, including fractures, osteoporosis, and osteoarthritis that affect a large number of individuals. Without intervention, the prevalence of osteopenia is projected to increase to 64.3 million Americans and that of osteoporosis to 11.9 million by the year 2030. Melatonin exerts numerous physiological effects, including the induction of anti-inflammatory and antioxidants, resetting circadian rhythms, and promoting wound healing and tissue regeneration, participating in the maintenance and regenerative processes of bones and cartilage. Objective: A systematic review was carried out to present the state of the art of melatonin regulation, mesenchymal stem cells, exosomes, microRNAs, and nutrients in the bone regeneration process. Methods: The systematic review rules (PRISMA) were followed. The search was carried out from July to September 2022 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using scientific articles from 2019 to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 126 articles were found. A total of 59 articles were fully evaluated and 46 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 9 studies at high risk of bias and 24 studies that did not meet the GRADE. Most studies showed homogeneity in their results, with I2 =97.8%>50%. The symmetrical funnel plot does not suggest a risk of bias between small sample-size studies. Based on the results, melatonin has important functions in regulating the regenerative activities of mesenchymal stem cells that modulate, together with nutrients, the activities of exosomes and microRNAs in the bone regeneration process

Terrestrial Biosphere Model Performance for Inter-Annual Variability of Land-Atmosphere CO2 Exchange

Interannual variability in biosphere-atmosphere exchange of CO2 is driven by a diverse range of biotic and abiotic factors. Replicating this variability thus represents the ‘acid test’ for terrestrial biosphere models. Although such models are commonly used to project responses to both normal and anomalous variability in climate, they are rarely tested explicitly against inter-annual variability in observations. Herein, using standardized data from the North American Carbon Program, we assess the performance of 16 terrestrial biosphere models and 3 remote sensing products against long-term measurements of biosphere-atmosphere CO2 exchange made with eddy-covariance flux towers at 11 forested sites in North America. Instead of focusing on model-data agreement we take a systematic, variability-oriented approach and show that although the models tend to reproduce the mean magnitude of the observed annual flux variability, they fail to reproduce the timing. Large biases in modeled annual means are evident for all models. Observed interannual variability is found to commonly be on the order of magnitude of the mean fluxes. None of the models consistently reproduce observed interannual variability within measurement uncertainty. Underrepresentation of variability in spring phenology, soil thaw and snowpack melting, and difficulties in reproducing the lagged response to extreme climatic events are identified as systematic errors, common to all models included in this study.Organismic and Evolutionary Biolog

Corpo-Imagem

The research aims to analyze the discursive modes, procedures influenced by production conditions , interpreting conditions and speech conditions, on the relationship between the body and the videographic expression. This way we will discuss a path built by poetics of the body, using as languages video, performance, and video installations. Motivated by this trend, we seek a broadening of these concepts and of artistic means of expression to conduct a survey on media analysis. The following questions guide our program of research and study: 1. The relationship between poetics and politics of the bodies; 2. The dialogue between body and camera; 3. Electronic art as preferred field to enhance the body's speech; 4. The "on screen" search of an episteme of the body.La investigación se propone analizar los modos discursivos, procedimientos influenciados por condiciones de producción, condiciones de interpretación y condiciones del discurso, en la relación entre el cuerpo y la expresión videográfica. De esta manera, abordaremos trabajos desarrollados que apuntan hacia un camino construido por la poética del cuerpo, utilizando como lenguajes el video, la performance y las videoinstalaciones. Motivados por esta tendencia, buscamos una ampliación de estos conceptos y de los medios artísticos de expresión para la realización de una pesquisa sobre análisis de los medios. Las siguientes cuestiones nortean nuestro programa de investigación y estudio: 1. La relación entre poéticas y políticas de los cuerpos; 2. El diálogo entre el cuerpo y la cámara; 3. El arte electrónica como campo preferencial para potenciar el discurso del cuerpo; 4. La búsqueda “en la pantalla” de una episteme del cuerpo.A pesquisa visa a analisar os modos discursivos, procedimentos influenciados por condições de produção, condições de interpretação e condições do discurso, na relação entre o corpo e a expressão videográfica. Dessa maneira, abordaremos trabalhos desenvolvidos que apontam para um caminho construído pela poética do corpo, utilizando como linguagens o vídeo, a performance e as videoinstalações. Motivados por esta tendência, buscamos uma ampliação desses conceitos e dos meios artísticos de expressão para a realização de uma pesquisa em análise das mídias. As seguintes questões norteiam nosso programa de pesquisa e estudo: 1. A relação entre poéticas e políticas dos corpos; 2. O diálogo entre o corpo e a câmera; 3. A arte eletrônica como campo preferencial para potencializar o discurso do corpo; 4. A busca “na tela” de uma episteme do corpo.

Os meandros da política externa dos Estados Unidos para o Afeganistão : o 11 de setembro e a Operação Liberdade Duradoura

Dissertação (mestrado)—Universidade de Brasília, Instituto de Relações Internacionais, Programa de Pós-Graduação em Relações Internacionais, 2012.Este trabalho pretende estudar a Política Externa dos Estados Unidos da América para o Afeganistão, após os atentados terroristas de 11 de setembro de 2001, a partir dos modelos de Análise de Política Externa (APE), em especial o apresentado por Walter Carlsnaes (1987; 1992; 2002), que conjuga a interatividade dinâmica entre agentes e estruturas. Sendo assim, o nosso questionamento central é por que a administração de George W. Bush optou pela mudança de regime e retirada dos Talibãs do poder no Afeganistão, em uma ação de envolvimento direto na política interna do país, após décadas de incursão indireta. A resposta para esse questionamento, como perceberemos, não pode ser somente encontrada nos desígnios de um pequeno grupo de pensadores e influenciadores da política externa dos Estados Unidos, os neoconservadores. A proposta de Carlsnaes (1987; 1992; 2002) sobre a Política Externa é que ela é multifatorial, o que nos impulsiona a estudar o histórico das relações entre os dois países, a conformação do governo Bush e a forma como a “Operação Liberdade Duradoura” foi lançada, em outubro de 2001, sempre cientes de compreender e explicar as intenções e as disposições que levaram a determinada ação de política externa. Já havia uma preocupação crescente com uma miríade de questões envolvendo o Afeganistão desde o início da administração do presidente republicano. Os atentados de setembro de 2001 foram a última centelha para que algo definitivo fosse feito. Esperamos assim mostrar ao fim do trabalho que a opção pela retirada dos Talibãs do poder seguiu os próprios caminhos das várias rodadas de reuniões no Comitê dos Dirigentes, através das quais os principais encarregados da política externa dos Estados Unidos se deram conta de que os Talibãs estavam diretamente vinculados a Al-Qaeda e a Osama Bin Laden. ______________________________________________________________________________ ABSTRACTThis work aims to study the Foreign Policy of the United States towards Afghanistan after the terrorist attacks of September 11, 2001, based on the Foreign Policy Analysis (FPA) model designed by Walter Carlsnaes (1987; 1992; 2002), that deals with the dynamic interaction between actors and structures. Thus, our central questions is why the George W. Bush administration opted for the regime change and the ousting of the Taliban in Afghanistan, directly involving itself in its country domestic affairs after decades of indirect incursions. The answer to this question, as we will realize, cannot only be found in the designs of a small group of thinkers and influencers of U.S foreign policy, the neoconservatives. Carlsnaes proposal is that Foreign Policy is multifactorial, which drives us to study the historical relationship between the two countries, the conformation of the Bush administration “Foreign Policy Executive” and the launching of “Operation Enduring Freedom” in October 2001, always aware to understand and to explain the intentions and dispositions that led to such actions of foreign policy. There had been already a growing concern over many issues involving Afghanistan since the very beginning of the Republican presidency. The September 11 attacks were only the last spark to such a direct action. We expect to confirm at the end of this work that the option for the removal of the Taliban from power followed the step-by-step process of decision-making within the Principals Committee, during which the main responsibles for foreign policy of the United States realized that the Taliban were directly linked to Al-Qaeda and Osama Bin Laden