Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue

The ubiquitous thioredoxin fold proteins catalyze oxidation, reduction, or disulfide exchange reactions depending on their redox properties. They also play vital roles in protein folding, redox control, and disease. Here, we have shown that a single residue strongly modifies both the redox properties of thioredoxin fold proteins and their ability to interact with substrates. This residue is adjacent in three-dimensional space to the characteristic CXXC active site motif of thioredoxin fold proteins but distant in sequence. This residue is just N-terminal to the conservative cis-proline. It is isoleucine 75 in the case of thioredoxin. Our findings support the conclusion that a very small percentage of the amino acid residues of thioredoxin-related proteins are capable of dictating the functions of these proteins

Top Management Team Stability and Corporate Social Responsibility: The Moderating Effects of Performance Aspiration Gap and Organisational Slack

Although studies on the impact of senior executives on corporate social responsibility (CSR) are relatively sufficient, they take a static perspective when investigating the different attitudes of senior executives towards fulfilling social responsibility. Few studies consider the impact of the dynamic changes in a top management team (TMT) on sustainable corporate development, especially social responsibility. We perform regression analysis on 2010–2019 data from Chinese listed firms to examine the relationship between TMT stability and CSR performance and consider the moderating roles of the performance aspiration gap and slack resources. We find that TMT stability has a positive impact on CSR performance and that the performance aspiration gap and slack resources negatively moderate the relationship between TMT stability and CSR performance. This study expands the current literature on the relationship between TMT characteristics and social responsibility, sheds light on what situations can cause agency problems, and provides practical guidance for the sustainable development of a firm and adequate performance of CSR.</jats:p

Top Management Team Stability and Corporate Social Responsibility: The Moderating Effects of Performance Aspiration Gap and Organisational Slack

Although studies on the impact of senior executives on corporate social responsibility (CSR) are relatively sufficient, they take a static perspective when investigating the different attitudes of senior executives towards fulfilling social responsibility. Few studies consider the impact of the dynamic changes in a top management team (TMT) on sustainable corporate development, especially social responsibility. We perform regression analysis on 2010&ndash;2019 data from Chinese listed firms to examine the relationship between TMT stability and CSR performance and consider the moderating roles of the performance aspiration gap and slack resources. We find that TMT stability has a positive impact on CSR performance and that the performance aspiration gap and slack resources negatively moderate the relationship between TMT stability and CSR performance. This study expands the current literature on the relationship between TMT characteristics and social responsibility, sheds light on what situations can cause agency problems, and provides practical guidance for the sustainable development of a firm and adequate performance of CSR

Sino-Hong Kong joint ventures: strategies, structures, and performance

published_or_final_versionBusinessDoctoralDoctor of Philosoph

Unpacking the organizational impacts of enterprise mobility using the repertory grid technique

Purpose The purpose of this paper is to analyze the organizational impacts of enterprise mobility and the configurations of mobile information technology (IT) impacts in companies with various value creation logics. Design/methodology/approach An exploratory approach combining semi-structured interview and repertory grid method was used to evaluate managers’ perspectives on the effects of mobile technologies. Findings The qualitative findings unearth managers’ perspectives about the organizational impacts of enterprise mobility, which are categorized into six intermediary dimensions and two fundamental impacts. A further analysis of material collected from interviews also shows the differential context-related configurations of mobile IT impacts in companies. Research limitations/implications This study contributes to literature on the business value of IT in general and mobile IT in particular by examining managers’ cognitive constructions of the organizational impacts of enterprise mobility and highlighting the complexity and context-related variety of mobile IT impacts. Practical implications This study provides valuable insights for managers and decision makers that enterprise mobility shows promise in enhancing a firm’s operational and marketing performance. Originality/value Different from prior literature, this study is an exploratory attempt to investigate complex enterprise-mobility-performance relationship and preliminarily uncovers that the mechanisms with which mobile IT influences firm performance vary in different organizational contexts. </jats:sec