Analysing the importance of different visual feature coefficients

A study is presented to determine the relative importance of different visual features for speech recognition which includes pixel-based, model-based, contour-based and physical features. Analysis to determine the discriminability of features is per- formed through F-ratio and J-measures for both static and tem- poral derivatives, the results of which were found to correlate highly with speech recognition accuracy (r = 0.97). Princi- pal component analysis is then used to combine all visual fea- tures into a single feature vector, of which further analysis is performed on the resulting basis functions. An optimal feature vector is obtained which outperforms the best individual feature (AAM) with 93.5 % word accuracy

Country Trade Costs, Comparative Advantage and the Pattern of Trade: Multi-Country and Product Panel Evidence

This paper investigates whether differences across countries in overall country-specific trade costs affect comparative advantage. It does so by examining whether the commodity composition of countries’ trade is driven by differences in countries’ trade costs, as well as by differences in traditional factor endowments. Industry export shares across up to 71 countries and 158 manufacturing industries for five year periods over the period 1972 to 1992 are shown to be greater in trade cost sensitive industries for countries with relatively low national trade costs. This is after controlling for factor-intensity differences across industries and for endowment differences (physical and human capital) between countries. Further, these relationships are more evident in exporting to global markets than to local or regional markets.Trade costs, comparative advantage

Objective measures for predicting the intelligibility of spectrally smoothed speech with artificial excitation

A study is presented on how well objective measures of speech quality and intelligibility can predict the subjective in- telligibility of speech that has undergone spectral envelope smoothing and simplification of its excitation. Speech modi- fications are made by resynthesising speech that has been spec- trally smoothed. Objective measures are applied to the mod- ified speech and include measures of speech quality, signal- to-noise ratio and intelligibility, as well as proposing the nor- malised frequency-weighted spectral distortion (NFD) measure. The measures are compared to subjective intelligibility scores where it is found that several have high correlation (|r| ≥ 0.7), with NFD achieving the highest correlation (r = −0.81

A Comparison of Perceptually Motivated Loss Functions for Binary Mask Estimation in Speech Separation

This work proposes and compares perceptually motivated loss functions for deep learning based binary mask estimation for speech separation. Previous loss functions have focused on maximising classification accuracy of mask estimation but we now propose loss functions that aim to maximise the hit mi- nus false-alarm (HIT-FA) rate which is known to correlate more closely to speech intelligibility. The baseline loss function is bi- nary cross-entropy (CE), a standard loss function used in binary mask estimation, which maximises classification accuracy. We propose first a loss function that maximises the HIT-FA rate in- stead of classification accuracy. We then propose a second loss function that is a hybrid between CE and HIT-FA, providing a balance between classification accuracy and HIT-FA rate. Eval- uations of the perceptually motivated loss functions with the GRID database show improvements to HIT-FA rate and ESTOI across babble and factory noises. Further tests then explore ap- plication of the perceptually motivated loss functions to a larger vocabulary dataset

Surgical pathology in sub-Saharan Africa—volunteering in Malawi

The breadth of material found in surgical pathology services in African countries differs from the common spectrum of "the West”. We report our experience of a voluntary work in the pathology departments of Blantyre and Lilongwe, Malawi. During a 6-week period, 405 cases (378 histology and 27 cytology cases) were processed. The vast majority showed significant pathological findings (n = 369; 91.1%): 175 cases (47.4%) were non-tumoral conditions with predominance of inflammatory lesions, e.g., schistosomiasis (n = 11) and tuberculosis (n = 11). There were 39 (10.6%) benign tumors or tumor-like lesions. Intraepithelial neoplasia of the cervix uteri dominated among premalignant conditions (n = 15; 4.1%). The large group of malignancies (n = 140; 37.9%) comprised 11 pediatric tumors (e.g., rhabdomyosarcoma, small blue round cell tumors) and 129 adult tumors. Among women (n = 76), squamous cell carcinomas (SCCs) of the cervix uteri predominated (n = 25; 32.9%), followed by breast carcinomas (n = 12; 15.8%) and esophageal SCC (n = 9; 11.8%). Males (n = 53) most often showed SCC of the esophagus (n = 9; 17.0%) and of the urinary bladder (n = 7; 13.2%). Lymphomas (n = 7) and Kaposi's sarcomas (n = 6) were less frequent. Differences compared to the western world include the character of the conditions in general, the spectrum of inflammatory lesions, and the young age of adult tumor patients (median 45years; range 18-87years). Providing pathology service in a low-resource country may be handicapped by lack of personnel, inadequate material resources, or insufficient infrastructure. Rotating volunteers offer a bridge for capacity building of both personnel and the local medical service; in addition, the volunteer's horizons are broadened professionally and personall

Discordance between clinical and immunological ART eligibility criteria for children in Malawi

Background: Since May 2014, all HIV positive children aged less than five years in Malawi are eligible for ART. For children older than five years they are eligible if they are in WHO stage III/IV, if stage I/II, if their CD4 750. Conclusion: Most children are correctly started on treatment using recent guidelines. 41% more children <5 years will be started on ART

Plasmodium falciparum gene expression measured directly from tissue during human infection

Background: During the latter half of the natural 48-h intraerythrocytic life cycle of human Plasmodium falciparum infection, parasites sequester deep in endothelium of tissues, away from the spleen and inaccessible to peripheral blood. These late-stage parasites may cause tissue damage and likely contribute to clinical disease, and a more complete understanding of their biology is needed. Because these life cycle stages are not easily sampled due to deep tissue sequestration, measuring in vivo gene expression of parasites in the trophozoite and schizont stages has been a challenge. Methods: We developed a custom nCounter® gene expression platform and used this platform to measure malaria parasite gene expression profiles in vitro and in vivo. We also used imputation to generate global transcriptional profiles and assessed differential gene expression between parasites growing in vitro and those recovered from malaria-infected patient tissues collected at autopsy. Results: We demonstrate, for the first time, global transcriptional expression profiles from in vivo malaria parasites sequestered in human tissues. We found that parasite physiology can be correlated with in vitro data from an existing life cycle data set, and that parasites in sequestered tissues show an expected schizont-like transcriptional profile, which is conserved across tissues from the same patient. Imputation based on 60 landmark genes generated global transcriptional profiles that were highly correlated with genome-wide expression patterns from the same samples measured by microarray. Finally, differential expression revealed a limited set of in vivo upregulated transcripts, which may indicate unique parasite genes involved in human clinical infections. Conclusions: Our study highlights the utility of a custom nCounter® P. falciparum probe set, validation of imputation within Plasmodium species, and documentation of in vivo schizont-stage expression patterns from human tissues. Electronic supplementary material The online version of this article (doi:10.1186/s13073-014-0110-6) contains supplementary material, which is available to authorized users

Maternal–Fetal Microtransfusions and HIV-1 Mother-to-Child Transmission in Malawi

Background: Between 25% and 35% of infants born to HIV-infected mothers become HIV-1 infected. One potential route of mother-to-child transmission (MTCT) could be through a breakdown in the placental barrier (i.e., maternal–fetal microtransfusions). Methods and Findings: Placental alkaline phosphatase (PLAP) is a 130-kD maternal enzyme that cannot cross the intact placental barrier. We measured PLAP activity in umbilical vein serum as an indicator of maternal–fetal microtransfusion, and related this to the risk of HIV-1 MTCT. A case-cohort study was conducted of 149 women randomly selected from a cohort of HIV-1-infected pregnant Malawians; these women served as a reference group for 36 cases of in utero MTCT and 43 cases of intrapartum (IP) MTCT. Cord PLAP activity was measured with an immunocatalytic assay. Infant HIV status was determined by real-time PCR. The association between cord PLAP activity and HIV-1 MTCT was measured with logistic regression using generalized estimating equations. Among vaginal deliveries, PLAP was associated with IP MTCT (risk ratio, 2.25 per $log_{10}$ ng/ml PLAP; 95% confidence interval, 0.95–5.32) but not in utero MTCT. In a multivariable model adjusted for HIV-1 RNA load, chorioamnionitis, and self-reported fever, the risk of IP MTCT almost tripled for every $log_{10}$ increase in cord PLAP activity (risk ratio, 2.87; 95% confidence interval, 1.05–7.83). Conclusion: These results suggest that during vaginal deliveries, placental microtransfusions are a risk factor for IP HIV-1 MTCT. Future studies are needed to identify factors that increase the risk for microtransfusions in order to prevent IP HIV-1 MTCT

The Role of Animal Models for Research on Severe Malaria

In light of the recent controversies over the role of animal models for research into the development of new treatments for severe malaria, particularly cerebral disease, a group of scientists came together to discuss the relative merits of a range of animal models and their overlap with the complex clinical syndromes of human disease. While it was not possible to fully resolve differences over the utility of the Plasmodium berghei ANKA model of experimental cerebral malaria, the meeting did bring the two research communities closer together to identify further work to provide information needed to validate the model and revitalise the development of other animal models displaying features of human pathology. The driving force behind this was the desire to ensure better translation of experimental findings into effective treatments for severe malaria