Synthesis and antibacterial activity of some 2,4,6-trisubstituted-1,3,5-triazines

A series of 2,4-bis(substitutedphenyl)-6-(4-(4-substitutedphenyl)thiazol-2-yl)-1,3,5-triazine- 2,4,6-triamine were synthesised, characterised by FT-IR, 1H NMR, 13C NMR, mass and elemental analysis and evaluated for in vitro antibacterial activity against three gram positive and gram negative bacteria by disk diffusion test and agar dilution technique with reference to streptomycin as standard. The antibacterial data revealed that compounds 2,4-bis(substitutedphenyl)-6-(4-(4-nitrophenyl)thiazol-2-yl)-1,3,5-triazine- 2,4,6-triamine had significant activity against the tested gram negative organism in reference to standard. However, these were nearly inactive against gram positive organisms.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Synthesis and antibacterial activity of some 2,4,6-trisubstituted-1,3,5-triazines

A series of 2,4-bis(substitutedphenyl)-6-(4-(4-substitutedphenyl)thiazol-2-yl)-1,3,5-triazine- 2,4,6-triamine were synthesised, characterised by FT-IR, 1H NMR, 13C NMR, mass and elemental analysis and evaluated for in vitro antibacterial activity against three gram positive and gram negative bacteria by disk diffusion test and agar dilution technique with reference to streptomycin as standard. The antibacterial data revealed that compounds 2,4-bis(substitutedphenyl)-6-(4-(4-nitrophenyl)thiazol-2-yl)-1,3,5-triazine- 2,4,6-triamine had significant activity against the tested gram negative organism in reference to standard. However, these were nearly inactive against gram positive organisms.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Synthesis and antibacterial activity of some 2,4,6-trisubstituted-1,3,5-triazines

A series of 2,4-bis(substitutedphenyl)-6-(4-(4-substitutedphenyl)thiazol-2-yl)-1,3,5-triazine- 2,4,6-triamine were synthesised, characterised by FT-IR, 1H NMR, 13C NMR, mass and elemental analysis and evaluated for in vitro antibacterial activity against three gram positive and gram negative bacteria by disk diffusion test and agar dilution technique with reference to streptomycin as standard. The antibacterial data revealed that compounds 2,4-bis(substitutedphenyl)-6-(4-(4-nitrophenyl)thiazol-2-yl)-1,3,5-triazine- 2,4,6-triamine had significant activity against the tested gram negative organism in reference to standard. However, these were nearly inactive against gram positive organisms.Colegio de Farmacéuticos de la Provincia de Buenos Aire

3D printing in biomedicine: advancing personalized care through additive manufacturing

The integration of three-dimensional (3D) printing techniques into the domains of biomedical research and personalized medicine highlights the evolving paradigm shifts within contemporary healthcare. This technological advancement signifies potential breakthroughs in patient-specific therapeutic interventions and innovations. This systematic review offers a critical assessment of the existing literature, elucidating the present status, inherent challenges, and prospective avenues of 3D printing in augmenting biomedical applications and formulating tailored medical strategies. Based on an exhaustive literature analysis comprising empirical studies, case studies, and extensive reviews from the past decade, pivotal sectors including tissue engineering, prosthetic development, drug delivery systems, and customized medical apparatuses are delineated. The advent of 3D printing provides precision in the fabrication of patient-centric implants, bio-structures, and devices, thereby mitigating associated risks. Concurrently, it facilitates the ideation of individualized drug delivery paradigms to optimize therapeutic outcomes. Notwithstanding these advancements, issues concerning material biocompatibility, regulatory compliance, and the economic implications of avant-garde printing techniques persist. To fully harness the transformative potential of 3D printing in healthcare, collaborative endeavors amongst academicians, clinicians, industrial entities, and regulatory bodies are paramount. With continued research and innovation, 3D printing is poised to redefine the trajectories of biomedical science and patient-centric care. The paper aims to justify the research objective of whether to what extent the integration of 3D printing technology in biomedicine enhances patient-specific treatment and contributes to improved healthcare outcomes

Unlocking the therapeutic potential of Garcinia cowa Rox. in diabetes management

Garcinia cowa Rox. is a tropical fruit traditionally used in various parts of Asia for medicinal purposes. Recent research has indicated that it may have potential as an antidiabetic drug. Studies have shown that the extract from the fruit of G. cowa can lower blood glucose levels in diabetic rats. This effect is believed to be due to various bioactive compounds, including flavonoids and xanthones, which have demonstrated antidiabetic properties. In addition, fruit extract has also been found to improve lipid metabolism, often disrupted in individuals with diabetes. The extract has been shown to reduce levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol while increasing high-density lipoprotein cholesterol levels. Further studies are needed to explore the full potential of G. cowa as an antidiabetic drug, including clinical trials in humans. However, these initial findings suggest that this tropical fruit is a promising natural and effective treatment option for individuals with diabetes.</jats:p