Quantum Degenerate Exciton-Polaritons in Thermal Equilibrium

We study the momentum distribution and relaxation dynamics of semiconductor microcavity polaritons by angle-resolved and time-resolved spectroscopy. Above a critical pump level, the thermalization time of polaritons at positive detunings becomes shorter than their lifetime, and the polaritons form a quantum degenerate Bose-Einstein distribution in thermal equilibrium with the lattice.Comment: Updated with the published versio

Relict Late Wisconsinan Dune Fields of the Northern Great Plains, Canada

Late Wisconsinan dune activity is investigated within the present-day boreal forest and parkland regions of the northern Great Plains, Canada, to extend the understanding of the spatial and temporal eolian record. Optical ages from stabilized sand dunes document the timing of past activity. Eolian activity ranges from about 16 ka in west-central Alberta to 9 ka in northwestern Saskatchewan. Between about 16 and 13 ka, dune activity in central Alberta occurred in an ice-proximal tundra setting along the margins of the Laurentide and Cordilleran ice sheets. Predominant dune-forming winds were from the west and northwest. Dune activity continued in this area between about 13 and 11 ka within parkland and grassland settings as the Laurentide Ice Sheet retreated to the northeast. Winds continued to blow from the west and northwest, and the climate was likely influenced by an increasingly dominant Pacific air mass. Also beginning at about 13 ka, dune-forming winds along the margins of the retreating Laurentide Ice Sheet were influenced by anticyclonic winds from the southeast that were maintained until about 9 ka. As the Laurentide Ice Sheet retreated, these southeasterly anticyclonic winds were successively replaced by winds from the northwest associated with the Pacific air mass. Dune activity across the region terminated in a time-transgressive manner from the southwest, at about 11 ka, to the northeast, at about 9 ka, with the establishment of boreal forest vegetation and reduced wind strength.Les auteurs étudient l’activité dunaire au Wisconsinien tardif dans la forêt boréale et la prairie-parc actuelles des Grandes Plaines septentrionales du Canada, afin d’approfondir les connaissances sur l’évolution spatiotemporelle de l’activité éolienne. Les âges optiques mesurés sur des dunes de sable stabilisées permettent de reconstituer la chronologie de l’activité passée. Les âges de l’activité éolienne s’échelonnent entre 16 ka dans le centre-ouest de l’Alberta et 9 ka dans le nord-ouest de la Saskatchewan. Entre 16 et 13 ka, l’activité dunaire dans le centre de l’Alberta a eu lieu dans un environnement de toundra juxtaglaciaire le long des marges des inlandsis laurentidien et cordillérien. Les vents efficaces prédominants soufflaient de l’ouest et du nord-ouest. L’activité dunaire s’est poursuivie dans cette région entre 13 et 11 ka dans des environnements de prairie-parc et de prairie herbageuse, avec le recul de l’Inlandsis laurentidien vers le nord-est. Les vents ont continué de souffler de l’ouest et du nord-ouest, et le climat a probablement été influencé par une masse d’air du Pacifique de plus en plus dominante. Également au début de 13 ka, les vents efficaces le long des marges de l’Inlandsis laurentidien en recul ont été influencées par des vents anticycloniques du sud-ouest, qui ont duré jusqu’à 9 ka. Avec le retrait de l’Inlandsis laurentidien, ces vents ont été successivement remplacés par des vents du nord-ouest associés à la masse d’air du Pacifique. L’activité dunaire dans la région s’est terminée de façon diachrone à partir du sud-ouest, vers 11 ka, jusqu’au nord-est, vers 9 ka, par l’établissement d’une végétation forestière boréale et la diminution de la force des vents

The Deuterium to Hydrogen Abundance Ratio Towards a Fourth QSO: HS0105+1619

We report the measurement of the primordial D/H abundance ratio towards QSO \object. The column density of the hydrogen in the $z \simeq 2.536$ Lyman limit system is high, \lnhi $= 19.422 \pm 0.009$ \cmm, allowing for the deuterium to be seen in 5 Lyman series transitions. The measured value of the D/H ratio towards QSO \object is found to be D/H$= 2.54 \pm 0.23 \times 10^{-5}$. The metallicity of the system showing D/H is found to be $\simeq 0.01$ solar, indicating that the measured D/H is the primordial D/H within the measurement errors. The gas which shows D/H is neutral, unlike previous D/H systems which were more highly ionized. Thus, the determination of the D/H ratio becomes more secure since we are measuring it in different astrophysical environments, but the error is larger because we now see more dispersion between measurements. Combined with prior measurements of D/H, the best D/H ratio is now D/H$= 3.0 \pm 0.4 \times 10^{-5}$, which is 10% lower than the previous value. The new values for the baryon to photon ratio, and baryonic matter density derived from D/H are $\eta = 5.6 \pm 0.5 \times 10^{-10}$ and \ob $=0.0205 \pm 0.0018$ respectively.Comment: Minor text and reference changes. To appear in the May 10, 2001 issue of the Astrophysical Journa

A practice-related risk score (PRS): a DOPPS-derived aggregate quality index for haemodialysis facilities

Background. The Dialysis Outcomes and Practice Patterns Study (DOPPS) database was used to develop and validate a practice-related risk score (PRS) based on modifiable practices to help facilities assess potential areas for improving patient care. Methods. Relative risks (RRs) from a multivariable Cox mortality model, based on observational haemodialysis (HD) patient data from DOPPS I (1996-2001, seven countries), were used. The four practices were the percent of patients with Kt/V >= 1.2, haemoglobin >= 11 g/dl (110 g/l), albumin >= 4.0 g/dl (40g/l) and catheter use, and were significantly related to mortality when modelled together. DOPPS II data (2002-2004, 12 countries) were used to evaluate the relationship between PRS and mortality risk using Cox regression. Results. For facilities in DOPPS I and II, changes in PRS over time were significantly correlated with changes in the standardized mortality ratio (SMR). The PRS ranged from 1.0 to 2.1. Overall, the adjusted RR of death was 1.05 per 0.1 points higher PRS (P < 0.0001). For facilities in both DOPPS I and II (N = 119), a 0.2 decrease in PRS was associated with a 0.19 decrease in SMR (P = 0.005). On average, facilities that improved PRS practices showed significantly reduced mortality over the same time frame. Conclusions. The PRS assesses modifiable HD practices that are linked to improved patient survival. Further refinements might lead to improvements in the PRS and will address regional variations in the PRS/mortality relationship

RNAi in Budding Yeast

RNA interference (RNAi), a gene-silencing pathway triggered by double-stranded RNA, is conserved in diverse eukaryotic species but has been lost in the model budding yeast Saccharomyces cerevisiae. Here, we show that RNAi is present in other budding yeast species, including Saccharomyces castellii and Candida albicans. These species use noncanonical Dicer proteins to generate small interfering RNAs, which mostly correspond to transposable elements and Y′ subtelomeric repeats. In S. castellii, RNAi mutants are viable but have excess Y′ messenger RNA levels. In S. cerevisiae, introducing Dicer and Argonaute of S. castellii restores RNAi, and the reconstituted pathway silences endogenous retrotransposons. These results identify a previously unknown class of Dicer proteins, bring the tool of RNAi to the study of budding yeasts, and bring the tools of budding yeast to the study of RNAi

The circulating proteinase inhibitor α-1 antitrypsin regulates neutrophil degranulation and autoimmunity.

Pathological inflammation and autoimmune disease frequently involve elevated neutrophil activity in the absence of infectious agents. Tumor necrosis factor-α (TNF-α) contributes to many of the problems associated with autoimmune diseases. We investigated the ability of serum α-1 antitrypsin (AAT) to control TNF-α biosynthesis and signaling in neutrophils and assessed whether AAT deficiency (AATD) is a TNF-α-related disease. In vitro studies demonstrate that serum AAT coordinates TNF-α intracellular signaling and neutrophil degranulation of tertiary and secondary granules via modulation of ligand-receptor interactions. AATD patients homozygous for the Z allele were characterized by increased activation of the TNF-α system, as demonstrated by increased membrane TNF-α levels and increased plasma concentrations of TNF receptor 1 and neutrophil-released secondary and tertiary granule proteins. The incidence of autoantibodies directed against degranulated lactoferrin and surface protein accessible to these antibodies was increased in ZZ-AATD, leading to an enhanced rate of neutrophil reactive oxygen species production. Treatment of ZZ-AATD individuals with AAT augmentation therapy resulted in decreased membrane TNF-α expression and plasma levels of granule antigenic proteins and immunoglobulin G class autoantibodies. These results provide a mechanism by which AAT augmentation therapy affects TNF-α signaling in the circulating neutrophil, indicating promising potential of this therapy for other TNF-α-related diseases

X-Ray Magnetic Circular Dichroism of Pulsed Laser Deposited Co2MnSn and Co2MnSb Thin Films Grown on GaAs (001)

We present the structural and element specific magnetic properties of Co2MnSn and Co2MnSb thin films grown on GaAs (100) substrates using pulsed laser deposition. X-ray magnetic circular dichroism (XMCD) spectra were measured for 400 A thick films at the L2,3 edges of Co and Mn. Element specific moments for Co and Mn in Co2MnSn were calculated from the x-ray absorption and XMCD spectra using the XMCD sum rules. The ratios of orbital to spin magnetic moments for Co and Mn were calculated for Co2MnSn and Co2MnSb

The Deuterium Abundance at z=0.701 towards QSO 1718+4807

We present constraints on the deuterium to hydrogen ratio (D/H) in the metal-poor gas cloud at redshift $z=0.701$ towards QSO 1718+4807. We use new Keck spectra in addition to Hubble Space Telescope (HST) and International Ultraviolet Explorer (IUE) spectra. We use an improved redshift and a lower \HI column density to model the absorption. The HST spectrum shows an asymmetric Lyman-$\alpha$ (\lya) feature which is produced by either \HI at a second velocity, or a high abundance of D. Three models with a single simple H+D component give $8 \times 10^{-5} < D/H < 57 \times 10^{-5}$ (95%), a much larger range than reported by Webb et al (1997a,b). A more sophisticated velocity distribution, or a second component is necessary for lower D/H. With two components, which could be a part of one absorbing structure, or separate clouds in a galaxy halo, we find $D/H < 50 \times 10^{-5}$. We do not know if this second component is present, but it is reasonable because 40 -- 100% of absorption systems with similar redshifts and \HI column densities have more than one component.Comment: 13 pages, 4 figures, to appear in the Astronomical Journal (Jan 1999