Sade's Itinerary of Transgression

"I would like to address the nature of transgression and its logic or itinerary in Sade's work. If this task is somewhat speculative and incomplete, it perhaps mirrors the foundational incompleteness of the more than sixteen extant volumes of Sade's writings. For a more exhaustive, if not definitive, resolution of the very issue of transgression, the analysis would have to continue the debate between Derrida and Foucault over the validity of Bataille's celebrated account of transgression, which in turn draws upon the earlier work of Roger Caillois." (opening paragraph of the article

A TECHNIQUE TO ESTIMATE INPUT PRODUCTIVITY FROM FARM DATA

Productivity Analysis,

Characterization of small molecules inhibiting the pro-angiogenic activity of the zinc finger transcription factor Vezf1

Discovery of inhibitors for endothelial-related transcription factors can contribute to the development of anti-angiogenic therapies that treat various diseases, including cancer. The role of transcription factor Vezf1 in vascular development and regulation of angiogenesis has been defined by several earlier studies. Through construction of a computational model for Vezf1, work here has identified a novel small molecule drug capable of inhibiting Vezf1 from binding to its cognate DNA binding site. Using structure-based design and virtual screening of the NCI Diversity Compound Library, 12 shortlisted compounds were tested for their ability to interfere with the binding of Vezf1 to DNA using electrophoretic gel mobility shift assays. We identified one compound, T4, which has an IC50 of 20 μM. Using murine endothelial cells, MSS31, we tested the effect of T4 on endothelial cell viability and angiogenesis by using tube formation assay. Our data show that addition of T4 in cell culture medium does not affect cell viability at concentrations lower or equal to its IC 50 but strongly inhibits the network formation by MSS31 in the tube formation assays. Given its potential efficacy, this inhibitor has significant therapeutic potential in several human diseases

Community Dimensions of Learning Object Repositories

This paper outlines some enablers and barriers in the use of learning object repositories (LORs) to support learning within a range of communities. Key dimensions of use of LORs as well as relationships between LORs and the learning communities that they aim to support are discussed. The LORs and communities analysed in the paper are SIESWE Learning Exchange (formerly Stor Curam), JORUM, IVIMEDS, and DIDET. Guided by the Activity Theory perspective, the LORs and the communities are analysed as sociocultural activity systems. Based on this analysis, some initial barriers and enablers for the use of LORs to support learning are outlined and implications for the future use of LORs are discussed

Derrida's critique of Husserl and the philosophy of presence

O autor reexamina a crítica de Derrida à fenomenologia de Husserl de forma a mostrar como a sua coerência estrutural emerge não tanto de uma redução a uma doutrina particular mas antes das exigências de uma concepção unitária, especificamente impostas pelas determinações epistemológicas e metafísicas da presenç