Vietnamese Women and Children Refugees in Hong Kong: An Argument against Arbitrary Detention

Anteckningar från Sundre, Gotland sydligaste socken. Onsdag 11 april 2012 Rivet, en smal udde av grus. Stark vind, öppen horisont. Vatten på nära nog alla håll. Här, längst ut, drabbades jag av fasa när havet ville döda mig, sluka min kropp. Letade efter gravarna men fann inget. Gick upp till Arendt i fyren. --- Mitt examensprojekt är min promenad tillsammans med historia, tempo, minne, tröghet, förflyttningar och förändringar, ruiner, myter samt högst personliga reflektioner. Det finns platser man verkligen tycker om, som man älskar. Jag vet flera platser som jag älskar att vara på, det här är en av dem. Få stannar till här, det är ett ställe man passerar. Jag vill vara ensam här. Vid mina besök, som på senare tid under projektets gång har varit mycket riktade, blir jag extremt fokuserad på platsen och bara platsen. Också som att kliva ur tjockan.Notes from the parish of Sundre, at the very south of Gotland. Wednesday April 11, 2012 Rivet, a small cpe of gravel. Strong wind, open horizon. Water in almost all directions. Here, at the nab, fright hit me when the sea wanted to liquidate me, swallow my body. Searched for the tombs but found nothing. Visited Arendt in the lighthouse. --- My degree project is my promenade together with history, tempo, memory, inertia, movements, ruins, myths and my very personal reflections. There are places you really like, that you love. There are several places that I love to be at, this is one of them. Few people halt here, this is a place you pass. I want to be alone here. At my visits, that during the project became more and more addressed, I become extremely focused at the place and the place only. Like stepping out of the mist

Discrete-velocity collision dynamics for polyatomic molecules

A multispeed discrete‐velocity molecular model of a rarefied gas is developed which permits quantitatively accurate simulation of mixtures of molecules of different mass which have both translational and internal rotational energies. In particular, the molecules are represented as having three discrete velocity components and a single discrete internal energy that does not directly affect the translational motion. During binary collisions, rotational and translational kinetic energies are exchanged according to a phenomenological model. Results are presented for the thermal relaxation to equilibrium of mixtures of H_2 and Ne, N_2 and O_2, and N_2 and CO_2. Good agreement is found with the corresponding continuous‐velocity results

Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects

Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the microtubule binding protein tau. While mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP17) causes aberrant microtubule binding and assembly of tau into filaments, the pathways leading to tau-mediated neurotoxicity in Alzheimer's disease and other neurodegenerative disorders in which tau protein is not genetically modified remain unknown. To test the hypothesis that axonal transport defects alone can cause pathological abnormalities in tau protein and neurodegeneration in the absence of mutant tau or amyloid β deposits, we induced transport defects by deletion of the kinesin light chain 1 (KLC1) subunit of the anterograde motor kinesin-1. We found that upon aging, early selective axonal transport defects in mice lacking the KLC1 protein (KLC1-/-) led to axonopathies with cytoskeletal disorganization and abnormal cargo accumulation. In addition, increased c-jun N-terminal stress kinase activation colocalized with aberrant tau in dystrophic axons. Surprisingly, swollen dystrophic axons exhibited abnormal tau hyperphosphorylation and accumulation. Thus, directly interfering with axonal transport is sufficient to activate stress kinase pathways initiating a biochemical cascade that drives normal tau protein into a pathological state found in a variety of neurodegenerative disorders including Alzheimer's disease.Fil: Falzone, Tomas Luis. Howard Hughes Medical Institute; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Stokin, Gorazd B.. University Psychiatric Hospital; EsloveniaFil: Lillo, Concepción. University of California at San Diego; Estados UnidosFil: Rodrigues, Elizabeth M.. Howard Hughes Medical Institute; Estados UnidosFil: Westerman, Eileen L.. Howard Hughes Medical Institute; Estados UnidosFil: Williams, David S.. University of California at San Diego; Estados UnidosFil: Goldstein, Lawrence S. B.. Howard Hughes Medical Institute; Estados Unido

Increased Yield of ttbb at Hadron Colliders in Low-Energy Supersymmetry

Light bottom squarks and gluinos have been invoked to explain the b quark pair production excess at the Tevatron. We investigate the associated production of ttbb at hadron colliders in this scenario, and find that the rates for this process are enhanced over the Standard Model prediction. If light gluinos exist, it may be possible to detect them at the Tevatron, and they could easily be observed at the LHC.Comment: 5p, references added, version accepted to PR

Arterial stiffness and wave reflection 1 year after a pregnancy complicated by hypertension.

Hypertensive disorders of pregnancy (HDP) are associated with cardiovascular disease (CVD) later in life. The authors investigated the association of HDP with blood pressure (BP) and arterial stiffness 1-year postpartum. Seventy-four participants, 33 with an HDP and 41 with uncomplicated pregnancies, were examined using applanation tonometry to measure BP, carotid-femoral pulse wave velocity (cfPWV), and augmentation index (AIx). On average, women with HDP had a 9 mm higher systolic BP (

Designing an automated clinical decision support system to match clinical practice guidelines for opioid therapy for chronic pain

Abstract Background Opioid prescribing for chronic pain is common and controversial, but recommended clinical practices are followed inconsistently in many clinical settings. Strategies for increasing adherence to clinical practice guideline recommendations are needed to increase effectiveness and reduce negative consequences of opioid prescribing in chronic pain patients. Methods Here we describe the process and outcomes of a project to operationalize the 2003 VA/DOD Clinical Practice Guideline for Opioid Therapy for Chronic Non-Cancer Pain into a computerized decision support system (DSS) to encourage good opioid prescribing practices during primary care visits. We based the DSS on the existing ATHENA-DSS. We used an iterative process of design, testing, and revision of the DSS by a diverse team including guideline authors, medical informatics experts, clinical content experts, and end-users to convert the written clinical practice guideline into a computable algorithm to generate patient-specific recommendations for care based upon existing information in the electronic medical record (EMR), and a set of clinical tools. Results The iterative revision process identified numerous and varied problems with the initially designed system despite diverse expert participation in the design process. The process of operationalizing the guideline identified areas in which the guideline was vague, left decisions to clinical judgment, or required clarification of detail to insure safe clinical implementation. The revisions led to workable solutions to problems, defined the limits of the DSS and its utility in clinical practice, improved integration into clinical workflow, and improved the clarity and accuracy of system recommendations and tools. Conclusions Use of this iterative process led to development of a multifunctional DSS that met the approval of the clinical practice guideline authors, content experts, and clinicians involved in testing. The process and experiences described provide a model for development of other DSSs that translate written guidelines into actionable, real-time clinical recommendations.http://deepblue.lib.umich.edu/bitstream/2027.42/78267/1/1748-5908-5-26.xmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78267/2/1748-5908-5-26.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/78267/3/1748-5908-5-26-S3.TIFFhttp://deepblue.lib.umich.edu/bitstream/2027.42/78267/4/1748-5908-5-26-S2.TIFFhttp://deepblue.lib.umich.edu/bitstream/2027.42/78267/5/1748-5908-5-26-S1.TIFFPeer Reviewe

Variation in Emission and Absorption Lines and Continuum Flux by Orbital Phase in Vela X-1

High resolution spectral studies were undertaken at orbital phases 0, 0.25 and 0.5 on the high-mass X-ray binary (HMXB) Vela X-1 using archival Chandra data. We present (a) the first detailed analysis of the multiple strong narrow emission lines present in phase 0.5 (b) an analysis of the absorption of the continuum in phase 0.5, and (c) the first detection of narrow emission and absorption lines in phase 0.25. Multiple fluorescent and H-and He-like emission lines in the band 1.6 - 20 Angstrom in eclipse are partially obscured at phase 0.25 by the X-ray continuum. The phase 0.25 spectrum displays 3 triplets, 2 with a blue-shifted resonance (r) line in absorption and the intercombination (i) and forbidden (f) lines in emission, and shows in absorption other blue-shifted lines seen in emission in eclipse. At phase 0.5 the soft X-ray continuum diminishes revealing an "eclipse-like" spectrum, however line flux values are around 13-fold those in eclipse. We conclude the narrow emission lines in Vela X-1 become apparent when the continuum is blocked from line of sight, either by eclipse or by scattering and/or absorption from a wake or cloud. The H-and He-like lines arise in warm photoionised regions in the stellar wind, while the fluorescent lines (including a Ni K alpha line) are produced in cooler clumps of gas outside these regions. Absorption of the 5-13 Angstrom continuum at phase 0.5 may be caused by an accretion wake comprised of dense stagnant photoionized plasma inside a Stromgren zone. Multiple fluorescent emission lines may be a common feature of the supergiant category of HMXBs.Comment: 29 pages, 7 figures, accepted for publication in the Astronomical Journa

A functional correlate of severity in alternating hemiplegia of childhood

OBJECTIVE: Mutations in ATP1A3, the gene that encodes the α3 subunit of the Na(+)/K(+) ATPase, are the primary cause of alternating hemiplegia of childhood (AHC). Correlations between different mutations and AHC severity were recently reported, with E815K identified in severe and D801N and G947R in milder cases. This study aims to explore the molecular pathological mechanisms in AHC and to identify functional correlates for mutations associated with different levels of disease severity. METHODS: Human wild type ATP1A3, and E815K, D801N and G947R mutants were expressed in Xenopus laevis oocytes and Na(+)/K(+) ATPase function measured. Structural homology models of the human α3 subunit containing AHC mutations were created. RESULTS: The AHC mutations examined all showed similar levels of reduction in forward cycling. Wild type forward cycling was reduced by coexpression with any mutant, indicating dominant negative interactions. Proton transport was measured and found to be selectively impaired only in E815K. Homology modeling showed that D801 and G947 lie within or near known cation binding sites while E815 is more distal. Despite its effect on proton transport, E815K was also distant from the proposed proton transport route. INTERPRETATION: Loss of forward cycling and dominant negativity are common and likely necessary pathomechanisms for AHC. In addition, loss of proton transport correlated with severity of AHC. D801N and G947R are likely to directly disrupt normal Na(+)/K(+) binding while E815K may disrupt forward cycling and proton transport via allosteric mechanisms yet to be elucidated

Entropy Function for Non-Extremal Black Holes in String Theory

We generalize the entropy function formalism to five-dimensional and four-dimensional non-extremal black holes in string theory. In the near horizon limit, these black holes have BTZ metric as part of the spacetime geometry. It is shown that the entropy function formalism also works very well for these non-extremal black holes and it can reproduce the Bekenstein-Hawking entropy of these black holes in ten dimensions and lower dimensions.Comment: 19 pages, no figure, JHEP3 style, to appear in JHE