Probing Spatial Variation Of The Fine-Structure Constant Using The CMB

The fine-structure constant, α, controls the strength of the electromagnetic interaction. There are extensions of the standard model in which α is dynamical on cosmological length and time scales. The physics of the cosmic microwave background (CMB) depends on the value of α. The effects of spatial variation in α on the CMB are similar to those produced by weak lensing: smoothing of the power spectrum, and generation of non-Gaussian features. These would induce a bias to estimates of the weak-lensing potential power spectrum of the CMB. Using this effect, Planck measurements of the temperature and polarization power spectrum, as well as estimates of CMB lensing, are used to place limits (95% C.L.) on the amplitude of a scale-invariant angular power spectrum of α fluctuations relative to the mean value (CαL=AαSI/[L(L+1)]) of AαSI≤1.6×10−5. The limits depend on the assumed shape of the α-fluctuation power spectrum. For example, for a white-noise angular power spectrum (CαL=AαWN), the limit is AαWN≤2.3×10−8. It is found that the response of the CMB to α fluctuations depends on a separate-universe approximation, such that theoretical predictions are only reliable for α multipoles with L≲100. An optimal trispectrum estimator can be constructed and it is found that it is only marginally more sensitive than lensing techniques for Planck but significantly more sensitive when considering the next generation of experiments. For a future CMB experiment with cosmic-variance limited polarization sensitivity (e.g., CMB-S4), the optimal estimator could detect α fluctuations with AαSI\u3e1.9×10−6 and AαWN\u3e1.4×10−9

Attempted DNA extraction from a Rancho La Brea Columbian mammoth (Mammuthus columbi): prospects for ancient DNA from asphalt deposits.

Fossil-bearing asphalt deposits are an understudied and potentially significant source of ancient DNA. Previous attempts to extract DNA from skeletons preserved at the Rancho La Brea tar pits in Los Angeles, California, have proven unsuccessful, but it is unclear whether this is due to a lack of endogenous DNA, or if the problem is caused by asphalt-mediated inhibition. In an attempt to test these hypotheses, a recently recovered Columbian mammoth (Mammuthus columbi) skeleton with an unusual pattern of asphalt impregnation was studied. Ultimately, none of the bone samples tested successfully amplified M. columbi DNA. Our work suggests that reagents typically used to remove asphalt from ancient samples also inhibit DNA extraction. Ultimately, we conclude that the probability of recovering ancient DNA from fossils in asphalt deposits is strongly (perhaps fatally) hindered by the organic compounds that permeate the bones and that at the Rancho La Brea tar pits, environmental conditions might not have been ideal for the general preservation of genetic material

Public policy to promote entrepreneurship: a call to arms

We debate the motivation for and effectiveness of public policies to encourage individuals to become entrepreneurs. Reviewing established evidence we find that most Western world policies do not greatly reduce or solve any market failures but instead waste taxpayers’ money, encourage those already intent on becoming entrepreneurs, and mostly generate one-employee businesses with low-growth intentions and a lack of interest in innovating. Most policy initiatives that would have the effect of promoting valuable entrepreneurship would not be recognizable as such, because they would primarily address other market failures: A central-payer health care would remove healthcare-related distortions affecting employment choices; greater STEM education would produce more engineers of which some start valuable new firms; and labor market reform to encourage hiring immigrants in jobs they have been educated for would reduce inefficient allocation of talent to entrepreneurship

Ola Bratteli and his diagrams

This article discusses the life and work of Professor Ola Bratteli (1946--2015). Family, fellow students, his advisor, colleagues and coworkers review aspects of his life and his outstanding mathematical accomplishments.Comment: 18 pages, 15 figure

Electromagnetic induction mapping at varied soil moisture reveals field-scale soil textural patterns and gravel lenses

Knowledge of the spatial distribution of soil textural properties is important for determining soil moisture storage and soil hydraulic transport properties. Capturing field heterogeneity without exhaustive sampling and costly sample analysis is difficult. Our objective was to employ electromagnetic induction (EMI) mapping in low apparent electrical conductivity (ECa) soils at varying soil water contents to capture time invariant properties such as soil texture. Georeferenced ECa measurements were taken using a ground conductivity meter on six different days where volumetric water content (θv) varied from 0.11 to 0.23. The 50 m × 50 m field included a subsurface gravelly patch in an otherwise homogeneous silt-loam alluvial soil. Ordinary block kriging predicted ECa at unsampled areas to produce 1-m resolution maps. Temporal stability analysis was used to divide the field into three distinct ECa regions. Subsequent ground-truthing confirmed the lowest conductivity region correlated with coarse textured soil parent materials associated with a former high-energy alluvial depositional area. Combining maps using temporal stability analysis gives the clearest image of the textural difference. These maps could be informative for modeling, experimental design, sensor placement and targeted zone management strategies in soil science, ecology, hydrology, and agricultural applications

HST Imaging Polarimetry of the Gravitational Lens FSC10214+4724

We present imaging polarimetry of the extremely luminous, redshift 2.3 IRAS source FSC10214+4724. The observations were obtained with HST's Faint Object Camera in the F437M filter, which is free of strong emission lines. The 0.7 arcsec long arc is unresolved to 0.04 arcsec FWHM in the transverse direction, and has an integrated polarization of 28 +/- 3 percent, in good agreement with ground-based observations. The polarization position angle varies along the arc by up to 35 deg. The overall position angle is 62 +/- 3 deg east of north. No counterimage is detected to B = 27.5 mag ($3\sigma$), giving an observed arc to counterimage flux ratio greater than 250, considerably greater than the flux ratio of 100 measured previously in the I-band. This implies that the configuration of the object in the source plane at the B-band is different from that at I-band, and/or that the lensing galaxy is dusty.Comment: 17 pages, 3 figures. Accepted for publication in Astronomical Journal, February 199

Meningococcal disease in children in Merseyside, England:a 31 year descriptive study

Meningococcal disease (MCD) is the leading infectious cause of death in early childhood in the United Kingdom, making it a public health priority. MCD most commonly presents as meningococcal meningitis (MM), septicaemia (MS), or as a combination of the two syndromes (MM/MS). We describe the changing epidemiology and clinical presentation of MCD, and explore associations with socioeconomic status and other risk factors. A hospital-based study of children admitted to a tertiary children's centre, Alder Hey Children's Foundation Trust, with MCD, was undertaken between 1977 to 2007 (n = 1157). Demographics, clinical presentations, microbiological confirmation and measures of deprivation were described. The majority of cases occurred in the 1-4 year age group and there was a dramatic fall in serogroup C cases observed with the introduction of the meningococcal C conjugate (MCC) vaccine. The proportion of MS cases increased over the study period, from 11% in the first quarter to 35% in the final quarter. Presentation with MS (compared to MM) and serogroup C disease (compared to serogroup B) were demonstrated to be independent risk factors for mortality, with odds ratios of 3.5 (95% CI 1.18 to 10.08) and 2.18 (95% CI 1.26 to 3.80) respectively. Cases admitted to Alder Hey were from a relatively more deprived population (mean Townsend score 1.25, 95% CI 1.09 to 1.41) than the Merseyside reference population. Our findings represent one of the largest single-centre studies of MCD. The presentation of MS is confirmed to be a risk factor of mortality from MCD. Our study supports the association between social deprivation and MCD

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Significance Alzheimer’s disease (AD) is the most common cause of dementia and is a major public health problem for which there is currently no disease-modifying treatment. There is an urgent need for greater understanding of the molecular mechanisms underlying neurodegeneration in patients to create better therapeutic options. Recently, genetic studies uncovered novel AD risk variants in the microglial receptor, triggering receptor expressed on myeloid cells 2 (TREM2). Previous studies suggested that loss of TREM2 function worsens amyloid-β (Aβ) plaque-related toxicity. In contrast, we observe TREM2 deficiency mitigates neuroinflammation and protects against brain atrophy in the context of tau pathology. These findings indicate dual roles for TREM2 and microglia in the context of amyloid versus tau pathology, which are important to consider for potential treatments targeting TREM2.</jats:p

On the origin of the large scale structures of the universe

We revise the statistical properties of the primordial cosmological density anisotropies that, at the time of matter radiation equality, seeded the gravitational development of large scale structures in the, otherwise, homogeneous and isotropic Friedmann-Robertson-Walker flat universe. Our analysis shows that random fluctuations of the density field at the same instant of equality and with comoving wavelength shorter than the causal horizon at that time can naturally account, when globally constrained to conserve the total mass (energy) of the system, for the observed scale invariance of the anisotropies over cosmologically large comoving volumes. Statistical systems with similar features are generically known as glass-like or lattice-like. Obviously, these conclusions conflict with the widely accepted understanding of the primordial structures reported in the literature, which requires an epoch of inflationary cosmology to precede the standard expansion of the universe. The origin of the conflict must be found in the widespread, but unjustified, claim that scale invariant mass (energy) anisotropies at the instant of equality over comoving volumes of cosmological size, larger than the causal horizon at the time, must be generated by fluctuations in the density field with comparably large comoving wavelength.Comment: New section added; final version to appear in Physical Review D; discussion extended and detailed with new calculations to support the claims of the paper; statistical properties of vacuum fluctuations now discussed in the context of FRW flat universe; new important conclussions adde

Exact Four-Dimensional Dyonic Black Holes and Bertotti-Robinson Spacetimes in String Theory

Conformal field theories corresponding to two-dimensional electrically charged black holes and to two-dimensional anti-de Sitter space with a covariantly constant electric field are simply constructed as $SL(2,R)/Z$ WZW coset models. The two-dimensional electrically charged black holes are related by Kaluza-Klein reduction to the 2+1-dimensional rotating black hole of Banados, Teitelboim and Zanelli, and our construction is correspondingly related to its realization as a WZW model. Four-dimensional spacetime solutions are obtained by tensoring these two-dimensional theories with $SU(2)/Z(m)$ coset models. These describe a family of dyonic black holes and the Bertotti--Robinson universe.Comment: 10 pages, harvmac, (Reference to Kaloper added.