Giving in Florida, 2015

Florida is home to a vibrant and growing grantmaking community addressing issues ranging from the arts to medical research to the sciences at the local, national, and even international level. This report outlines the state of giving in Florida and includes key findings, a broad variety of information detailing the philanthropic landscape of the state, and predictions for the future of giving in Florida

Value of Relationships Between State Charity Regulators & Philanthropy

This publication seeks to help enhance the accountability and effectiveness of foundations and their oversight by state charity regulators by highlighting the value of ongoing, productive relationships between regulators and the philanthropic sector, and demonstrating how such relationships can be successfully achieved. The publication is intended for people working in both charity regulators' offices and the charitable sector

Protein Phosphatase 2A Interacts with the Na+,K+-ATPase and Modulates Its Trafficking by Inhibition of Its Association with Arrestin

Background: The P-type ATPase family constitutes a collection of ion pumps that form phosphorylated intermediates during ion transport. One of the best known members of this family is the Na +,K +-ATPase. The catalytic subunit of the Na +,K +-ATPase includes several functional domains that determine its enzymatic and trafficking properties. Methodology/Principal Findings: Using the yeast two-hybrid system we found that protein phosphatase 2A (PP2A) catalytic C-subunit is a specific Na +,K +-ATPase interacting protein. PP-2A C-subunit interacted with the Na +,K +-ATPase, but not with the homologous sequences of the H +,K +-ATPase. We confirmed that the Na +,K +-ATPase interacts with a complex of A- and C-subunits in native rat kidney. Arrestins and G-protein coupled receptor kinases (GRKs) are important regulators of G-protein coupled receptor (GPCR) signaling, and they also regulate Na +,K +-ATPase trafficking through direct association. PP2A inhibits association between the Na +,K +-ATPase and arrestin, and diminishes the effect of arrestin on Na +,K +-ATPase trafficking. GRK phosphorylates the Na +,K +-ATPase and PP2A can at least partially reverse this phosphorylation. Conclusions/Significance: Taken together, these data demonstrate that the sodium pump belongs to a growing list of io

Advancing Racial Equity in Philanthropy: A Scan of Philanthropy-Serving Organizations

United Philanthropy Forum conducted a scan of regional and national philanthropy-serving organizations (PSOs) in February through May 2018 to get a more comprehensive understanding of PSOs' current work and future needs to advance racial equity in philanthropy. The scan involved both a survey that asked about PSOs' current work, future needs and greatest challenges in advancing racial equity, plus in-depth interviews to discuss what it takes to do this work effectively and to identify their key challenges, barriers and opportunities for addressing systemic inequities.The scan reflects the input of 43 regional and national PSOs that participated in the scan survey and/or the scan interviews, representing more than half of the Forum's membership. The scan report includes the Forum's plan for action to respond to the scan's key findings.The Forum's racial equity scan was made possible in part thanks to support from the Ford Foundation and W.K. Kellogg Foundation