THE APPLICATION OF ICTS THROUGH THE USE OF DATABASES AND ONLINE RESOURCES IN HIGHER EDUCATION

A documentary review was carried out on the production and publication of research papers related to the study of ICT variables, databases, higher education as online resources within the different study methodologies at the university level. The purpose of the bibliometric analysis proposed in this document was to know the main characteristics of the volume of publications registered in the Scopus database during the period 201 7-2022, achieving the identification of 82 publications in total. The information provided by this platform was organized through graphs and figures categorizing the information by the Year of Publication, Country of Origin, Area of Knowledge and Type of Publication. Once these characteristics have been described, the position of different authors on the proposed theme is referenced through a qualitative analysis. Among the main findings made through this research, it is found that Spain with 19 publications, was the country with the highest scientific production registered on behalf of authors affiliated with institutions of dichto nation. The Area of Knowledge that made the greatest contribution to the construction of bibliographic material referring  to the study of the implementation of queries to Databases, ICT Resources as a strategy in university education was  Social Sciences with 50 published documents, and the Type of Publication that was most used during the period indicated above was  the Journal Article that represents 52% of the total scientific production

INFORMATION AND COMMUNICATION TECHNOLOGIES (ICTs) IN EDUCATION: QUALITY INDICATORS

A documentary review was carried out on producing and publishing research papers related to the study of the variables ICTs, Education and Quality. The bibliometric analysis proposed in this document was to know the main characteristics of the volume of publications registered in the Scopus database from 2017-2022, identifying 154 publications. The information provided by the said platform was organized employing tables and figures categorizing the information by Year of Publication, Country of Origin, Area of Knowledge and Type of Publication. Once these characteristics were described, a qualitative analysis was used to refer to the position of different authors on the proposed topic. Among the main findings of this research, Spain was the country with the highest number of records in Scopus, with 26 publications on the analysis of the impact of ICT on quality indicators in education. The area of knowledge that made the most significant contribution to the study variables was Social Sciences, with 86 published documents, and the type of publication that was most used during the period mentioned above was reviews, which accounted for 50% of the total scientific production

Synthesis and in vitro antiprotozoal activity of some 2- amino-4-phenyloxazole derivatives

Purpose: To prepare some 2-amino-4-(p-substituted phenyl)-oxazole derivatives and to evaluate their in vitro antiprotozoal activity against Giardia lamblia and Trichomonas vaginalis.Methods: The 2-amino-4-(p-substituted phenyl)-oxazoles (a-g) were synthesized by microwave (MW) irradiation of mixtures of p-substituted 2-bromoacetophenones and urea in dimethylformamide (DMF). All compounds were identified by 1H and 13C nuclear magnetic resonance (NMR) spectroscopy and lowand high-resolution mass spectrometry (HRMS). NMR assignments were made based on heteronuclear single quantum coherence (HSQC) and heteronuclear multiple bond correlation (HMBC) experiments. Each synthesized compound’s melting point was determined. Antiprotozoal activity against Giardia intestinalis and Trichomonas vaginalis was quantified using a rigorous and sensitive subculture method. The commercial drug, metronidazole, was used as positive control. The 50 % inhibitory concentration (IC50) of the antiprotozoal agents for each protozoa was determined.Results: Seven 2-amino-4-(p-substituted phenyl)-oxazoles (a-g) were synthesized. The most active compounds against G. lamblia was 2-amino-4-(p-benzoyloxyphenyl)-oxazole (3d) with an IC50 of 1.17 μM, while compound 3e (2-amino-4-(p-bromophenyl)-oxazole) showed the highest anti-trichomonal activity (IC50, 1.89 μM).Conclusion: The in vitro antigiardial activity of 2-amino-4-(p-benzoyloxyphenyl) oxazole was higher than that exhibited by metronidazole; however, it is necessary increase the number of synthetic derivatives in order to be able to determine their structure-activity relationship.Keywords: Antiprotozoal, 2-Amino-4-phenyl-oxazoles, Giardia lamblia, Trichomonas vaginali

Subjective attitudinal perception of students from secondary level establishments towards physical education teachers

La percepción de la clase de educación física por parte de los estudiantes es un factor importante porque dependiendo de cómo los escolares perciban estas vivencias, se generarán determinadas creencias o valoraciones, las que influyen en la actitud para enfrentar estas experiencias corporales cada vez que se presenten. 176 estudiantes (14.74 ± 0.68), pertenecientes a los establecimientos particulares subvencionados de la comuna de Coronel. El objetivo de esta investigación es analizar la percepción actitudinal subjetiva de los estudiantes de enseñanza secundaria hacia los profesores de EF. Para evaluar la percepción actitudinal de los estudiantes hacia el profesor de educación física, se utilizó una modificación del cuestionario de actitudes de los escolares hacia la educación física. En los resultados de la actitudes positivas, se puede indicar que el alumnado valoro mayormente el ítem “Muy de acuerdo” en la pregunta “Mi profesor/a de educación física sabe mucho”, en las actitudes negativas la pregunta “Mi profesor/a de educación física levanta la voz frecuentemente” fue el mayor porcentaje en el ítem “Muy de acuerdo” . En el análisis comparativo entre hombres y mujeres para la percepción positiva reporto (p = 0.63) y negativa (p = 0.10). En el análisis por edades para la escala positiva (p = 0.01), para la escala negativa (p = 0.25). El alumnado observo mayormente actitudes positivas de y muy pocas negativas en el profesor de educación física, sin observase diferencias entre hombres y mujeres, en las edades se reportaron diferencias en las actitudes positivas y negativas del profesor, informando que los alumnos de con más edad evalúan más críticamente las actitudes positivas y negativas del profesor de EF

Terapia regenerativa en un lecho quirúrgico. Reporte de un caso

The use of biocompatible materials plays an important role in tissue engineering, by applying principles in various branches of dentistry, such as periodontics, oral surgery, maxillofacial and implantology. In implantology, the main problems lie in the lack of an adequate bone and the proximity of the attachments to the anatomical structures. Advanced surgical procedures, that act as a complement of dental implants, apply the materials used for guided bone regeneration (GBR), therapy used to promote bone regeneration in maxillary bones defects, to create an appropriate bed in positioning implants. In many cases, the advantage of using some type of material to fill the defect, is to increase the surface where the response occurs, obtaining, after the bone healing process, a higher volume of tissue. On the other hand, there have been autologous materials such as platelet rich plasma (PRP) which is a material used to regenerate hard and soft tissues based on the production and release of growth factors contained in platelets, which can improve the healing of surgical defects. The purpose of this study is to describe the preparation of a bed for an implant with GBR, using a bovine heterologous graft, PRP and platelet-rich fibrin (PRF) as a membrane, in a male patient with partially edentulous in the space of the 22 DU, recording its evolution for 1 year, resulting in an increase in the lobby-palata vertical height and width acceptable for the placement of an implant.El uso de materiales biocompatibles juega un papel importante en la ingeniería tisular, aplicando principios en varias ramas de la odontología, tales como periodoncia, cirugía bucal, maxilofacial e implantología. En la implantología, los problemas principales radican en la falta de hueso adecuado y la proximidad de los aditamentos a las estructuras anatómicas. Los procedimientos quirúrgicos avanzados que actúan como un complemento de los implantes dentales aplican los materiales empleados para la regeneración ósea guiada (ROG), terapia que se usacon el fin de promover la regeneración de hueso en defectos óseos maxilares, para crear un lecho adecuado en el posicionamiento de implantes.En muchos casos, la ventaja de utilizar algún tipo de material para rellenar el defecto, es aumentar la superficie donde se produce la respuesta, obteniendo, luego del proceso de cicatrización ósea, mayor volumen de tejido. Por otra parte, han surgido materiales autólogos como el plasma rico en plaquetas (PRP) que es un material utilizado para regenerar tejidos blandos y duros basándose en la producción y liberación de factores de crecimiento contenidos en las plaquetas, que pueden mejorar la cicatrización de defectos quirúrgicos. El objetivo del presente estudioes describir la preparación de un lecho para un implante con ROG, utilizando un injerto heterólogo bovino, PRP y fibrina rica en plaquetas (FRP) como una membrana, en un paciente masculino con edentulismo parcial en el espacio de la UD 22 registrando su evolución durante 1 año, resultando en un incremento en altura vertical y anchura vestíbulo-palatina aceptable para la colocación de un implante

Efecto de los inhibidores selectivos de la recaptación de serotonina en los linfocitos de pacientes con depresión

Depression is the most frequent mental disorder worldwide whose pathology is complex due to the psychological and pathophysiological factors that it involves. Pharmacological treatment is essential, nevertheless, it presents high percentages of resistance to which several investigations have identified that alterations in the immune system play a decisive role. For this reason, the objective of this article is to review the current bibliography on the effects of selective serotonin reuptake inhibitors (SSRIs), the first line of pharmacological management, on changes in the immune system in patients with depression. The alteration of lymphocytes and cytokines in the pathophysiology of depression and against SSRIs is evident. However, extensive research is required to establish normal immune patterns and their affectation against these factors. This will allow the generation of new pharmacological targets that reduce the resistance, chronicity and recurrence of depression.La depresión es el trastorno mental más frecuente a nivel mundial cuya patología es compleja por los factores psicológicos y fisiopatológicos que conlleva. El tratamiento farmacológico es fundamental, no obstante, presenta altos porcentajes de resistencia ante lo cual varias investigaciones han identificado que las alteraciones del sistema inmune juegan un papel decisivo. Es por ello que el objetivo de este artículo es revisar la bibliografía actual sobre los efectos de los inhibidores selectivos de la recaptación de serotonina (ISRS), primera línea de manejo farmacológico, sobre las alteraciones del sistema inmune en pacientes con depresión. Es evidente la alteración de los linfocitos y citoquinas en la fisiopatología de la depresión y frente a los ISRS. Sin embargo, se requieren amplias investigaciones para establecer los patrones inmunes normales y su afectación frente a estos factores. Esto permitirá generar nuevas metas farmacológicas que disminuyan la resistencia, cronicidad y recurrencia de la depresión

Efficacy and Safety of Text Messages Targeting Adherence to Cardiovascular Medications in Secondary Prevention: TXT2HEART Colombia Randomized Controlled Trial

BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality worldwide, with a prevalence of approximately 100 million patients. There is evidence that antiplatelet agents and antihypertensive medications could reduce the risk of new vascular events in this population; however, treatment adherence is very low. An SMS text messaging intervention was recently developed based on behavior change techniques to increase adherence to pharmacological treatment among patients with a history of ASCVD. OBJECTIVE: This study aims to evaluate the efficacy and safety of an SMS text messaging intervention to improve adherence to cardiovascular medications in patients with ASCVD. METHODS: A randomized controlled clinical trial for patients with a prior diagnosis of cardiovascular events, such as acute myocardial infarction, unstable angina, cerebrovascular disease, or peripheral artery disease, in one center in Colombia was conducted. Patients randomized to the intervention arm were assigned to receive SMS text messages daily for the first 4 weeks, 5 SMS text messages on week 5, 3 SMS text messages each in weeks 6 and 7, and 1 SMS text message weekly from week 8 until week 52. In contrast, patients in the control arm received a monthly SMS text message reminding them of the next study appointment and the importance of the study, requesting information about changes in their phone number, and thanking them for participating in the study. The primary endpoint was the change in low-density lipoprotein cholesterol (LDL-C) levels, whereas the secondary endpoints were the changes in thromboxane B2 levels, heart rate, systolic and diastolic blood pressure, medication adherence, cardiac and noncardiac mortality, and hospitalization. Linear regression analyses and bivariate tests were performed. RESULTS: Of the 930 randomized patients, 805 (86.5%) completed follow-up and were analyzed for the primary endpoint. There was no evidence that the intervention changed the primary outcome (LDL-C levels; P=.41) or any of the secondary outcomes evaluated (all P>.05). There was also no evidence that the intervention was associated with adverse events. CONCLUSIONS: In this study, there was no evidence that a behavior modification intervention delivered by SMS text messaging improved LDL-C levels, blood pressure levels, or adherence at 12 months. More research is needed to evaluate whether different SMS text messaging strategies, including personalized messages and different timings, are effective; future studies should include mixed methods to better understand why, for whom, and in which context (eg, health system or social environment) SMS text messaging interventions work (or not) to improve adherence in patients with ASCVD. TRIAL REGISTRATION: ClinicalTrials.gov NCT03098186; https://clinicaltrials.gov/ct2/show/NCT03098186. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.1136/bmjopen-2018-028017

Introducción

La memoria es ese espacio de hilos delgados y gruesos por el que es complejo transitar. Los días, los meses y los años la convierten en un terreno impredecible de zonas fangosas; pero sobre ella, venciendo obstáculos, siempre hay que volver.De eso trata este libro, de volver sobre el pasado de 12 colombianos que hoy superan los 80 años, y que fueron testigos de la época de La Violencia, que se establece desde 1930 y que se complejiza el 9 de abril de 1948, con el asesinato de líder político Jorge Eliecer Gaitán

Psychometric characteristics of the Spanish version of instruments to measure neck pain disability

[EN] Background. The NDI, COM and NPQ are evaluation instruments for disability due to NP. There was no Spanish version of NDI or COM for which psychometric characteristics were known. The objectives of this study were to translate and culturally adapt the Spanish version of the Neck Disability Index Questionnaire (NDI), and the Core Outcome Measure (COM), to validate its use in Spanish speaking patients with non-specific neck pain (NP), and to compare their psychometric characteristics with those of the Spanish version of the Northwick Pain Questionnaire (NPQ). Methods. Translation/re-translation of the English versions of the NDI and the COM was done blindly and independently by a multidisciplinary team. The study was done in 9 primary care Centers and 12 specialty services from 9 regions in Spain, with 221 acute, subacute and chronic patients who visited their physician for NP: 54 in the pilot phase and 167 in the validation phase. Neck pain (VAS), referred pain (VAS), disability (NDI, COM and NPQ), catastrophizing (CSQ) and quality of life (SF-12) were measured on their first visit and 14 days later. Patients' self-assessment was used as the external criterion for pain and disability. In the pilot phase, patients' understanding of each item in the NDI and COM was assessed, and on day 1 test-retest reliability was estimated by giving a second NDI and COM in which the name of the questionnaires and the order of the items had been changed. Results. Comprehensibility of NDI and COM were good. Minutes needed to fill out the questionnaires [median, (P25, P75)]: NDI. 4 (2.2, 10.0), COM: 2.1 (1.0, 4.9). Reliability: [ICC, (95%CI)]: NDI: 0.88 (0.80, 0.93). COM: 0.85 (0.75,0.91). Sensitivity to change: Effect size for patients having worsened, not changed and improved between days 1 and 15, according to the external criterion for disability: NDI: -0.24, 0.15, 0.66; NPQ: -0.14, 0.06, 0.67; COM: 0.05, 0.19, 0.92. Validity: Results of NDI, NPQ and COM were consistent with the external criterion for disability, whereas only those from NDI were consistent with the one for pain. Correlations with VAS, CSQ and SF-12 were similar for NDI and NPQ (absolute values between 0.36 and 0.50 on day 1, between 0.38 and 0.70 on day 15), and slightly lower for COM (between 0.36 and 0.48 on day 1, and between 0.33 and 0.61 on day 15). Correlation between NDI and NPQ: r = 0.84 on day 1, r = 0.91 on day 15. Correlation between COM and NPQ: r = 0.63 on day 1, r = 0.71 on day 15. Conclusion. Although most psychometric characteristics of NDI, NPQ and COM are similar, those from the latter one are worse and its use may lead to patients' evolution seeming more positive than it actually is. NDI seems to be the best instrument for measuring NP-related disability, since its results are the most consistent with patient's assessment of their own clinical status and evolution. It takes two more minutes to answer the NDI than to answer the COM, but it can be reliably filled out by the patient without assistanceS

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality