Radical Couplings as Key Steps for the Preparation of Derivatives of Nonactic Acid

Summary.: Free radical couplings from furan, as cheap starting material, were studied in view of developing a rapid strategy en route to the synthesis of derivatives of nonactin. The chain containing the alcohol function was introduced in one or two steps in 86% yield. For the introduction of the second chain with the ester function two different coupling methods were tested. Starting from the advanced intermediates obtained nonactin derivatives can be prepared by catalytic hydrogenation of the furan rin

Malonylation/Decarbalkoxylation of Furan Derivatives as Key Steps for the Preparation of Nonactic Acid Derivatives. Part I [1]

Summary.: A malonylation/decarbalkoxylation sequence from 2-substituted furans was investigated in view of developing a scalable synthesis of hydrophobic nonactic acid analogue

Estudio de factibilidad de la compra de un incinerador para materiales Absorbentes Contaminados con Hidrocarburos (MACH) en la empresa SERTRASA Oíl Recycling

Presenta un estudio de factibilidad de la compra de un horno incinerador para materiales sólidos contaminados con hidrocarburos en SERTRASA correspondiente al periodo del año 2015 el año 2025. Se realiza un estudio de mercado para proyectar la demanda del año 2015 al año 2025. Proyecta un estudio financiero para saber la rentabilidad del proyecto

Plan de implementación del uso de pizarras digitales interactivas en el quehacer académico y administrativo de la comunidad universitaria de la Universidad Centroamericana (UCA)

Trabajo que consistió en elaborar un plan de implementación del uso de pizarras digitales en el quehacer académico y administrativo de la comunidad universitaria de la UCA; proponiendo el buen uso y sostenibilidad de las mismas y el aporte a la mejora de las funciones académicas y administrativas

AMPA Antagonists: From bench to bedside.

AMPA receptors mediate most of the excitatory neurotransmission in the mammalian central nervous system. They also play a key role in synaptic plasticity in the CNS and in memory processes. They may thereby have utility in a number of CNS disorders. In recent years several classes of AMPA receptor antagonists, both competitive and non-competitive, have been reported in the literature. Compounds that present a number of advantages in terms of potency, selectivity and pharmacokinetic properties are currently undergoing clinical evaluation. First successful clinical results in the treatment of epilepsy, the treatment of migraine, as analgesics as well as for the treatment of hyperalgesia and allodynia, have been reported. In the near future, the most important applications for the AMPA receptor antagonists will probably be as neuroprotectant in various neurodegenerative diseases. The present perspective covers recent history of competitive and non-competitive AMPA receptor antagonists design, clinical results obtained with these compounds and emerging therapeutic opportunities