The future of the district heating system at the University of Bridgeport

Linfeng Zhang, Junling Hu, and David Cote's poster on district heating systems by examining the heating loop at the University of Bridgeport

The Utilization of Fuel Cell Waste Heat at the University of Bridgeport

District heating system is cost effective and helps to reduce green house gases. It uses the waste heat from existing power plants to provide low temperature heat to the commercial and residential buildings. At UB, the 1.4 MW fuel cell system is owned by another company and the waste heat is free to us. Currently, less than 50% of the waste heat is utilized in several buildings

Searching for Dust around Hyper Metal-Poor Stars

We examine the mid-infrared fluxes and spectral energy distributions for metal-poor stars with iron abundances [Fe/H] $\lesssim-5$, as well as two CEMP-no stars, to eliminate the possibility that their low metallicities are related to the depletion of elements onto dust grains in the formation of a debris disk. Six out of seven stars examined here show no mid-IR excess. These non-detections rule out many types of circumstellar disks, e.g. a warm debris disk ($T\!\le\!290$ K), or debris disks with inner radii $\le1$ AU, such as those associated with the chemically peculiar post-AGB spectroscopic binaries and RV Tau variables. However, we cannot rule out cooler debris disks, nor those with lower flux ratios to their host stars due to, e.g. a smaller disk mass, a larger inner disk radius, an absence of small grains, or even a multicomponent structure, as often found with the chemically peculiar Lambda Bootis stars. The only exception is HE0107-5240, for which a small mid-IR excess near 10 microns is detected at the 2-$\sigma$ level; if the excess is real and associated with this star, it may indicate the presence of (recent) dust-gas winnowing or a binary system.Comment: Accepted for publication in Ap

Trends in the Globular Cluster Luminosity Function of Early-Type Galaxies

We present results from a study of the globular cluster luminosity function (GCLF) in a sample of 89 early-type galaxies observed as part of the ACS Virgo Cluster Survey. Using a Gaussian parametrization of the GCLF, we find a highly significant correlation between the GCLF dispersion, sigma, and the galaxy luminosity, M_B, in the sense that the GC systems in fainter galaxies have narrower luminosity functions. The GCLF dispersions in the Milky Way and M31 are fully consistent with this trend, implying that the correlation between sigma and galaxy luminosity is more fundamental than older suggestions that GCLF shape is a function of galaxy Hubble type. We show that the sigma - M_B relation results from a bonafide narrowing of the distribution of (logarithmic) cluster masses in fainter galaxies. We further show that this behavior is mirrored by a steepening of the GC mass function for relatively high masses, M >~ 3 x 10^5 M_sun, a mass regime in which the shape of the GCLF is not strongly affected by dynamical evolution over a Hubble time. We argue that this trend arises from variations in initial conditions and requires explanation by theories of cluster formation. Finally, we confirm that in bright galaxies, the GCLF "turns over" at the canonical mass scale of M_TO ~ 2 x 10^5 M_sun. However, we find that M_TO scatters to lower values (~1-2 x 10^5 M_sun) in galaxies fainter than M_B >~ -18.5, an important consideration if the GCLF is to be used as a distance indicator for dwarf ellipticals.Comment: 4 pages, 3 figures. Accepted for publication in ApJ Letters. Also available at http://www.cadc.hia.nrc.gc.ca/community/ACSVCS/publications.htm

The infrared imaging spectrograph (IRIS) for TMT: the science case

The InfraRed Imaging Spectrograph (IRIS) is a first-light instrument being designed for the Thirty Meter Telescope (TMT). IRIS is a combination of an imager that will cover a 16.4" field of view at the diffraction limit of TMT (4 mas sampling), and an integral field unit spectrograph that will sample objects at 4-50 mas scales. IRIS will open up new areas of observational parameter space, allowing major progress in diverse fields of astronomy. We present the science case and resulting requirements for the performance of IRIS. Ultimately, the spectrograph will enable very well-resolved and sensitive studies of the kinematics and internal chemical abundances of high-redshift galaxies, shedding light on many scenarios for the evolution of galaxies at early times. With unprecedented imaging and spectroscopy of exoplanets, IRIS will allow detailed exploration of a range of planetary systems that are inaccessible with current technology. By revealing details about resolved stellar populations in nearby galaxies, it will directly probe the formation of systems like our own Milky Way. Because it will be possible to directly characterize the stellar initial mass function in many environments and in galaxies outside of the the Milky Way, IRIS will enable a greater understanding of whether stars form differently in diverse conditions. IRIS will reveal detailed kinematics in the centers of low-mass galaxies, allowing a test of black hole formation scenarios. Finally, it will revolutionize the characterization of reionization and the first galaxies to form in the universe.Comment: to appear in Proc. SPIE 773

The ACS Fornax Cluster Survey. II. The Central Brightness Profiles of Early-Type Galaxies: A Characteristic Radius on Nuclear Scales and the Transition from Central Luminosity Deficit to Excess

We analyse HST surface brightness profiles for 143 early-type galaxies in the Virgo and Fornax Clusters. Sersic models provide accurate descriptions of the global profiles with a notable exception: the observed profiles deviate systematically inside a characteristic "break" radius of R_b ~ 0.02R_e where R_e is the effective radius of the galaxy. The sense of the deviation is such that bright galaxies (M_B < -20) typically show central light deficits with respect to the inward extrapolation of the Sersic model, while the great majority of low- and intermediate-luminosity galaxies (-19.5 < M_B < -15) show central light excesses; galaxies occupying a narrow range of intermediate luminosities (-20 < M_B < -19.5) are usually well fitted by Sersic models over all radii. The slopes of the central surface brightness profiles, when measured at fixed fractions of R_e, vary smoothly as a function of galaxy luminosity in a manner that depends sensitively on the choice of measurement radius. We show that a recent claim of strong bimodality in slope is likely an artifact of the galaxy selection function used in that study. To provide a more robust characterization of the inner regions of galaxies, we introduce a parameter that describes the central luminosity deficit or excess relative to the inward extrapolation of the outer Sersic model. We find that this parameter varies smoothly over the range of ~ 720 in blue luminosity spanned by the Virgo and Fornax sample galaxies, with no evidence for a dichotomy. We argue that the central light excesses (nuclei) in M_B > -19 galaxies may be the analogs of the dense central cores that are predicted by some numerical simulations to form via gas inflows. (ABRIDGED)Comment: To appear in the Astrophysical Journal, December 2007. Full resolution paper available at http://www.cfa.harvard.edu/~ajordan/ACSFCS/Home.htm

Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in liposarcoma.

While liposarcoma is the second most common soft tissue malignant tumor, the molecular pathogenesis in this malignancy is poorly understood. Our goal was therefore to expand the understanding of molecular mechanisms that drive liposarcoma and identify therapeutically-susceptible genetic alterations. We studied a cohort of high-grade liposarcomas and benign lipomas across multiple disease sites, as well as two liposarcoma cell lines, using multiplexed mutational analysis. Nucleic acids extracted from diagnostic patient tissue were simultaneously interrogated for 150 common mutations across 15 essential cancer genes using a clinically-validated platform for cancer genotyping. Western blot analysis was implemented to detect activation of downstream pathways. Liposarcoma cell lines were used to determine the effects of PI3K targeted drug treatment with or without chemotherapy. We identified mutations in the PIK3CA gene in 4 of 18 human liposarcoma patients (22%). No PIK3CA mutations were identified in benign lipomas. Western blot analysis confirmed downstream activation of AKT in both PIK3CA mutant and non-mutant liposarcoma samples. PI-103, a dual PI3K/mTOR inhibitor, effectively inhibited the activation of the PI3K/AKT in liposarcoma cell lines and induced apoptosis. Importantly, combination with PI-103 treatment strongly synergized the growth-inhibitory effects of the chemotherapy drugs doxorubicin and cisplatin in liposarcoma cells. Taken together, these findings suggest that activation of the PI3K/AKT pathway is an important cancer mechanism in liposarcoma. Targeting the PI3K/AKT/pathway with small molecule inhibitors in combination with chemotherapy could be exploited as a novel strategy in the treatment of liposarcoma

Determination of the standard deviation for proficiency assessment from past participant’s performances

The “uncertainty function” introduced by Thompson et al. estimates the reproducibility standard deviation (SR) as a function of concentration. This model was successfully applied to a data set derived from three proficiency testing schemes aiming at the quantification of three toxic elements (cadmium, lead and mercury) in blood and urine. A threshold concentration was determined for each element. Below this concentration SR is found to be constant, while above it the reproducibility relative standard deviation is constant. This model allows the a priori estimation of standard deviation for performance assessment for proficiency testing rounds.JRC.D.5-Standards for Food Bioscienc