The Infrared Properties of Submillimeter Galaxies: Clues From Ultra-Deep 70 Micron Imaging

We present 70 micron properties of submillimeter galaxies (SMGs) in the Great Observatories Origins Deep Survey (GOODS) North field. Out of thirty submillimeter galaxies (S_850 > 2 mJy) in the central GOODS-N region, we find two with secure 70 micron detections. These are the first 70 micron detections of SMGs. One of the matched SMGs is at z ~ 0.5 and has S_70/S_850 and S_70/S_24 ratios consistent with a cool galaxy. The second SMG (z = 1.2) has infrared-submm colors which indicate it is more actively forming stars. We examine the average 70 micron properties of the SMGs by performing a stacking analysis, which also allows us to estimate that S_850 > 2 mJy SMGs contribute 9 +- 3% of the 70 micron background light. The S_850/S_70 colors of the SMG population as a whole is best fit by cool galaxies, and because of the redshifting effects these constraints are mainly on the lower z sub-sample. We fit Spectral Energy Distributions (SEDs) to the far-infrared data points of the two detected SMGs and the average low redshift SMG (z_{median}= 1.4). We find that the average low-z SMG has a cooler dust temperature than local ultraluminous infrared galaxies (ULIRGs) of similar luminosity and an SED which is best fit by scaled up versions of normal spiral galaxies. The average low-z SMG is found to have a typical dust temperature T = 21 -- 33 K and infrared luminosity L_{8-1000 micron} = 8.0 \times 10^11 L_sun. We estimate the AGN contribution to the total infrared luminosity of low-z SMGs is less than 23%.Comment: Accepted by ApJ. 14 pages, 6 figures. Minor revisions 20th Dec 200

Spitzer Mid-Infrared Spectroscopy of Infrared Luminous Galaxies at z~2 III: Far-IR to Radio Properties and Optical Spectral Diagnostics

We present the far-IR, millimeter, and radio photometry as well as optical and near-IR spectroscopy of a sample of 48 z~1-3 Spitzer-selected ULIRGs with IRS mid-IR spectra. Our goals are to compute their bolometric emission, and to determine both the presence and relative strength of their AGN and starburst components. We find that strong-PAH sources tend to have higher 160um and 1.2mm fluxes than weak-PAH sources. The depth of the 9.7um silicate feature does not affect MAMBO detectability. We fit the far-IR SEDs of our sample and find an average ~7x10^{12}Lsun for our z>1.5 sources. Spectral decomposition suggests that strong-PAH sources typically have ~20-30% AGN fractions. Weak-PAH sources by contrast tend to have >~70% AGN fractions, with a few sources having comparable contributions of AGN and starbursts. The optical line diagnostics support the presence of AGN in the bulk of the weak-PAH sources. With one exception, our sources are narrow-line sources, show no obvious correspondence between the optical extinction and the silicate feature depth, and, in two cases, show evidence for outflows. Radio AGN are present in both strong-PAH and weak-PAH sources. This is supported by our sample's far-IR-to-radio ratios (q) being consistently below the average value of 2.34 for local star-forming galaxies. We use survival analysis to include the lower-limits given by the radio-undetected sources, arriving at =2.07+/-0.01 for our z>1.5 sample. In total, radio and, where available, optical line diagnostics support the presence of AGN in 57% of the z>1.5 sources, independent of IR-based diagnostics. For higher-z sources, the AGN luminosities alone are estimated to be >10^{12}Lsun, which, supported by the [OIII] luminosities, implies that the bulk of our sources host obscured quasars.Comment: 22 pages, 14 figures, accepted for publication in Ap

An Analysis of Private School Closings

We add to the small literature on private school supply by exploring exits of K-12 private schools. We find that the closure of private schools is not an infrequent event, and use national survey data from the National Center for Education Statistics to study closures of private schools. We assume that the probability of an exit is a function of excess supply of private schools over the demand, as well as the school's characteristics such as age, size, and religious affiliation. Our empirical results generally support the implications of the model. Working Paper 07-0

Imaging Carbon Monoxide Emission in the Starburst Galaxy NGC 6000

We present measurements of carbon monoxide emission in the central region of the nearby starburst NGC 6000 taken with the Submillimeter Array. The J=2-1 transition of 12CO, 13CO, and C18O were imaged at a resolution of ~3''x2'' (450x300 pc). We accurately determine the dynamical center of NGC 6000 at R.A(J2000.0)=15h49m49.5s and dec(J2000.0)=-29d23'13'' which agrees with the peak of molecular emission position. The observed CO dynamics could be explained in the context of the presence of a bar potential affecting the molecular material, likely responsible for the strong nuclear concentration where more than 85% of the gas is located. We detect a kinematically detached component of dense molecular gas at relatively high velocity which might be fueling the star formation. A total nuclear dynamical mass of 7x10^9 Msun is derived and a total mass of gas of 4.6x10^8 Msun, yielding a Mgas/Mdyn~6%, similar to other previously studied barred galaxies with central starbursts. We determined the mass of molecular gas with the optically thin isotopologue C18O and we estimate a CO-to-H2 conversion factor X(CO)=0.4x10^20 cm-2/(K km s-1) in agreement with that determined in other starburst galaxies.Comment: 31 pages, 7 figures. Accepted for publication in Astronomical Journal

Spatially Resolved Chemistry in Nearby Galaxies I. The Center of IC 342

We have imaged emission from the millimeter lines of eight molecules--C2H, C34S, N2H+, CH3OH, HNCO, HNC, HC3N, and SO--in the central half kpc of the nearby spiral galaxy IC 342. The 5" (~50 pc) resolution images were made with OVRO. Using these maps we obtain a picture of the chemistry within the nuclear region on the sizescales of individual GMCs. Bright emission is detected from all but SO. There are marked differences in morphology for the different molecules. A principal component analysis is performed to quantify similarities and differences among the images. This analysis reveals that while all molecules are to zeroth order correlated, that is, they are all found in dense molecular clouds, there are three distinct groups of molecules distinguished by the location of their emission within the nuclear region. N2H+, C18O, HNC and HCN are widespread and bright, good overall tracers of dense molecular gas. C2H and C34S, tracers of PDR chemistry, originate exclusively from the central 50-100 pc region, where radiation fields are high. The third group of molecules, CH3OH and HNCO, correlates well with the expected locations of bar-induced orbital shocks. The good correlation of HNCO with the established shock tracer molecule CH3OH is evidence that this molecule, whose chemistry has been uncertain, is indeed produced by processing of grains. HC3N is observed to correlate tightly with 3mm continuum emission, demonstrating that the young starbursts are the sites of the warmest and densest molecular gas. We compare our HNC images with the HCN images of Downes et al. (1992) to produce the first high resolution, extragalactic HCN/HNC map: the HNC/HCN ratio is near unity across the nucleus and the correlation of both of these gas tracers with the star formation is excellent. (Abridged).Comment: 54 pages including 10 figures and 8 tables. Accepted for publication in Ap

Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.Abstract Background Male infertility is a common cause of reproductive failure in humans. In mice, targeted deletions of the genes coding for FKBP6 or FKBP52, members of the FK506 binding protein family, can result in male infertility. In the case of FKBP52, this reflects an important role in potentiating Androgen Receptor (AR) signalling in the prostate and accessory glands, but not the testis. In infertile men, no mutations of FKBP52 or FKBP6 have been found so far, but the gene for FKBP-like (FKBPL) maps to chromosome 6p21.3, an area linked to azoospermia in a group of Japanese patients. Methods To determine whether mutations in FKBPL could contribute to the azoospermic phenotype, we examined expression in mouse and human tissues by RNA array blot, RT-PCR and immunohistochemistry and sequenced the complete gene from two azoospermic patient cohorts and matching control groups. FKBPL-AR interaction was assayed using reporter constructs in vitro. Results FKBPL is strongly expressed in mouse testis, with expression upregulated at puberty. The protein is expressed in human testis in a pattern similar to FKBP52 and also enhanced AR transcriptional activity in reporter assays. We examined sixty patients from the Japanese patient group and found one inactivating mutation and one coding change, as well as a number of non-coding changes, all absent in fifty-six controls. A second, Irish patient cohort of thirty showed another two coding changes not present in thirty proven fertile controls. Conclusions Our results describe the first alterations in the gene for FKBPL in azoospermic patients and indicate a potential role in AR-mediated signalling in the testis.Published versio

The Canada-UK Deep Submillimetre Survey: The Survey of the 14-hour field

We have used SCUBA to survey an area of 50 square arcmin, detecting 19 sources down to a 3sigma sensitivity limit of 3.5 mJy at 850 microns. We have used Monte-Carlo simulations to assess the effect of source confusion and noise on the SCUBA fluxes and positions, finding that the fluxes of sources in the SCUBA surveys are significantly biased upwards and that the fraction of the 850 micron background that has been resolved by SCUBA has been overestimated. The radio/submillmetre flux ratios imply that the dust in these galaxies is being heated by young stars rather than AGN. We have used simple evolution models based on our parallel SCUBA survey of the local universe to address the major questions about the SCUBA sources: (1) what fraction of the star formation at high redshift is hidden by dust? (2) Does the submillimetre luminosity density reach a maximum at some redshift? (3) If the SCUBA sources are proto-ellipticals, when exactly did ellipticals form? However, we show that the observations are not yet good enough for definitive answers to these questions. There are, for example, acceptable models in which 10 times as much high-redshift star formation is hidden by dust as is seen at optical wavelengths, but also acceptable ones in which the amount of hidden star formation is less than that seen optically. There are acceptable models in which very little star formation occurred before a redshift of three (as might be expected in models of hierarchical galaxy formation), but also ones in which 30% of the stars have formed by this redshift. The key to answering these questions are measurements of the dust temperatures and redshifts of the SCUBA sources.Comment: 41 pages (latex), 17 postscript figures, to appear in the November issue of the Astronomical Journa

Neuroprotection in a Novel Mouse Model of Multiple Sclerosis

The authors acknowledge the support of the Barts and the London Charity, the Multiple Sclerosis Society of Great Britain and Northern Ireland, the National Multiple Sclerosis Society, USA, notably the National Centre for the Replacement, Refinement & Reduction of Animals in Research, and the Wellcome Trust (grant no. 092539 to ZA). The siRNA was provided by Quark Pharmaceuticals. The funders and Quark Pharmaceuticals had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript