Dust Emission Features in NGC 7023 between 0.35 and 2.5 micron: Extended Red Emission (0.7 micron) and Two New Emission Features (1.15 and 1.5 micron)

We present 0.35 to 2.5 micron spectra of the south and northwest filaments in the reflection nebula NGC 7023. These spectra were used to test the theory of Seahra & Duley that carbon nanoparticles are responsible for Extended Red Emission (ERE). Our spectra fail to show their predicted second emission band at 1.0 micron even though both filaments exhibit strong emission in the familiar 0.7 micron ERE band. The northwest filament spectrum does show one, and possibly two, new dust emission features in the near-infrared. We clearly detect a strong emission band at 1.5 micron which we tentatively attribute to beta-FeSi_2 grains. We tentatively detect a weaker emission band at 1.15 micron which coincides with the location expected for transitions from the conduction band to mid-gap defect states of silicon nanoparticles. This is added evidence that silicon nanoparticles are responsible for ERE as they already can explain the observed behavior of the main visible ERE band.Comment: 9 pages, color figures, accepted to the ApJ, color and b/w versions available at http://dirty.as.arizona.edu/~kgordon/papers/ere_1um.htm

Demonstration of methods for analytical measurement of natural circulation flow in EBR-II

Statement of responsibility on title page reads: R. J. Witt and J. E. Meyer, Includes MIT technical contributions from J. I. Choi, D. D. Lanning, J. E. Meyer, A. L. Schor, R. J. Witt and R. D. Wittmeier.""February, 1986."Includes bibliographical references (leaf 44)Final project reportSupported by U.S. Dept. of Energy, Breeder Technology Program, Division of Educational Programs, Argonne National Laborator

The accretion disc in the quasar SDSS J0924+0219

We present single-epoch multi-wavelength optical-NIR observations of the "anomalous" lensed quasar SDSS J0924+0219, made using the Magellan 6.5-metre Baade telescope at Las Campanas Observatory, Chile. The data clearly resolve the anomalous bright image pair in the lensed system, and exhibit a strong decrease in the anomalous flux ratio with decreasing wavelength. This is interpreted as a result of microlensing of a source of decreasing size in the core of the lensed quasar. We model the radius of the continuum emission region, sigma, as a power-law in wavelength, sigma lambda^zeta. We place an upper limit on the Gaussian radius of the u'-band emission region of 3.04E16 h70^{-1/2} (/M_sun)^{1/2} cm, and constrain the size-wavelength power-law index to zeta<1.34 at 95% confidence. These observations rule out an alpha-disc prescription for the accretion disc in SDSS J0924+0219 with 94% confidence.Comment: 8 pages, 5 figures. Accepted for publication in MNRA

Multi-Messenger Gravitational Wave Searches with Pulsar Timing Arrays: Application to 3C66B Using the NANOGrav 11-year Data Set

When galaxies merge, the supermassive black holes in their centers may form binaries and, during the process of merger, emit low-frequency gravitational radiation in the process. In this paper we consider the galaxy 3C66B, which was used as the target of the first multi-messenger search for gravitational waves. Due to the observed periodicities present in the photometric and astrometric data of the source of the source, it has been theorized to contain a supermassive black hole binary. Its apparent 1.05-year orbital period would place the gravitational wave emission directly in the pulsar timing band. Since the first pulsar timing array study of 3C66B, revised models of the source have been published, and timing array sensitivities and techniques have improved dramatically. With these advances, we further constrain the chirp mass of the potential supermassive black hole binary in 3C66B to less than $(1.65\pm0.02) \times 10^9~{M_\odot}$ using data from the NANOGrav 11-year data set. This upper limit provides a factor of 1.6 improvement over previous limits, and a factor of 4.3 over the first search done. Nevertheless, the most recent orbital model for the source is still consistent with our limit from pulsar timing array data. In addition, we are able to quantify the improvement made by the inclusion of source properties gleaned from electromagnetic data to `blind' pulsar timing array searches. With these methods, it is apparent that it is not necessary to obtain exact a priori knowledge of the period of a binary to gain meaningful astrophysical inferences.Comment: 14 pages, 6 figures. Accepted by Ap

Persistence and change in interregional differences in entrepreneurship: England and Wales, 1921–2011

The paper explores time-persistence in interregional differences of self-employment rates in England and Wales in the 1921–2011 period by using census data. The results suggest a strong path-dependence in entrepreneurship as past self-employment rates have strong bearing on future ones. However, there is also some rank mobility reflected in the upward movements of London boroughs and downward movements of primarily coastal areas. Rank mobility relates to structural changes, changes in human capital, regional age structures and immigration

DNA methylation-based classification of central nervous system tumours.

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology

Determination of the Deep Inelastic Contribution to the Generalised Gerasimov-Drell-Hearn Integral for the Proton and Neutron

The virtual photon absorption cross section differences [sigma_1/2-sigma_3/2] for the proton and neutron have been determined from measurements of polarised cross section asymmetries in deep inelastic scattering of 27.5 GeV longitudinally polarised positrons from polarised 1H and 3He internal gas targets. The data were collected in the region above the nucleon resonances in the kinematic range nu < 23.5 GeV and 0.8 GeV**2 < Q**2 < 12 GeV**2. For the proton the contribution to the generalised Gerasimov-Drell-Hearn integral was found to be substantial and must be included for an accurate determination of the full integral. Furthermore the data are consistent with a QCD next-to-leading order fit based on previous deep inelastic scattering data. Therefore higher twist effects do not appear significant.Comment: 6 pages, 3 figures, 1 table, revte

Comprehensive glycosylation profiling of IgG and IgG-fusion proteins by top-down MS with multiple fragmentation techniques

We employed top- and middle-down analyses with multiple fragmentation techniques including electron transfer dissociation (ETD), electron capture dissociation (ECD), and matrix-assisted laser desorption ionization in-source decay (MALDI-ISD) for characterization of a reference monoclonal antibody (mAb) IgG1 and a fusion IgG protein. Fourier transform ion cyclotron resonance (FT-ICR) or high performance liquid chromatography electrospray ionization (HPLC-ESI) on an Orbitrap was employed. These experiments provided a comprehensive view on the protein species; especially for different glycosylation level in these two proteins, which showed good agreement with oligosaccharide profiling. Top- and middle-down MS provided additional information regarding glycosylation sites and different combinational protein species that were not available from oligosaccharide mapping or conventional bottom-up analysis. Finally, incorporating a limited enzymatic digestion by immunoglobulin G-degrading enzyme of Streptococcus pyogene (IdeS) with MALDI-ISD analysis enabled extended sequence coverage of the internal region of protein without pre-fractionation. Biological significance: Oligosaccharide profiling together with top- and middle-down methods enabled: 1) detection of heterogeneous glycosylated protein species and sites in intact IgG1 and fusion proteins with high mass accuracy, 2) estimation of relative abundance levels of protein species in the sample, 3) confirmation of the protein termini structural information, and 4) improved sequence coverage by MALDI-ISD analysis for the internal regions of the proteins without sample pre-fractionation

Dust attenuation in disk-dominated galaxies: evidence for the 2175A dust feature

The attenuation of starlight by interstellar dust is investigated in a sample of low redshift, disk-dominated star-forming galaxies using photometry from GALEX and SDSS. By considering broadband colors as a function of galaxy inclination we are able to confidently separate trends arising from increasing dust opacity from possible differences in stellar populations, since stellar populations do not correlate with inclination. All commonly employed dust attenuation curves (such as the Calzetti curve for starbursts, or a power-law curve) provide poor fits to the ultraviolet colors for moderately and highly inclined galaxies. This conclusion rests on the fact that the average FUV-NUV color varies little from face-on to edge-on galaxies, while other colors such as NUV-u and u-r vary strongly with inclination. After considering a number of model variations, we are led to speculate that the presence of the strong dust extinction feature at 2175A seen in the Milky Way (MW) extinction curve is responsible for the observed trends. Independent of our interpretation, these results imply that the modeling of dust attenuation in the ultraviolet is significantly more complicated than traditionally assumed. These results also imply a very weak dependence of the FUV-NUV color on total FUV attenuation, and we conclude from this that it is extremely difficult to use only the observed UV spectral slope to infer the total UV dust attenuation, as is commonly done. We propose several simple tests that might finally identify the grain population responsible for the 2175A feature.Comment: 16 pages, 10 figures. ApJ accepte