Tax incentives for R&D

A long-standing concern surrounding the performance of the UK economy is its perceived failure to maintain the same technological pace as its competitors. Industrial research and development (R&D) expenditure as a proportion of GDP fell during the 1980s at a time when all other G7 countries increased the proportion of their output given over to R&D. This ratio is now lower in the UK than in most other G7 countries. If this world-wide trend toward more R&D indicates that industrial production is becoming increasingly science-based, then the UK may be in danger of becoming a relatively low-tech economy. One purpose of this article is to examine whether there is a rational basis for these fears.

Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy.

ObjectivesTo examine the impact of serum-derived bovine immunoglobulin, an oral medical food known to neutralize bacterial antigen and reduce intestinal inflammation, on restoration of mucosal immunity and gastrointestinal function in individuals with HIV enteropathy.DesignOpen-label trial with intensive 8-week phase of bovine serum immunoglobulin (SBI) 2.5 g twice daily with a 4-week washout period and an optional 9-month extension study.MethodsHIV enteropathy was defined as chronic gastrointestinal symptoms including frequent loose or watery stools despite no identifiable, reversible cause. Upper endoscopy for tissue immunofluorescent antibody assay and disaccharide gut permeability/absorption studies were performed before and after 8 weeks of SBI to test mucosal immunity and gastrointestinal function. Blood was collected for markers of microbial translocation, inflammation, and collagen kinetics. A validated gastrointestinal questionnaire assessed changes in symptoms.ResultsAll eight participants experienced profound improvement in symptoms with reduced bowel movements/day (P = 0.008) and improvements in stool consistency (P = 0.008). Gut permeability was normal before and after the intervention, but D-xylose absorption increased in seven of eight participants. Mucosal CD4 lymphocyte densities increased by a median of 139.5 cells/mm2 from 213 to 322 cells/mm2 (P = 0.016). Intestinal-fatty acid binding protein (I-FABP), a marker of enterocyte damage, initially rose in seven of eight participants after 8 weeks (P = 0.039), and then fell below baseline in four of five who continued receiving SBI (P = 0.12). Baseline serum I-FABP levels were negatively correlated with subsequent rise in mucosal CD4 lymphocyte densities (r = -0.74, P = 0.046).ConclusionSBI significantly increases intestinal mucosal CD4 lymphocyte counts, improves duodenal function, and showed evidence of promoting intestinal repair in the setting of HIV enteropathy

Effects of Dehydration on Balance as Measured by the Balance Error Scoring System

The purpose of this study was to identify the effects of active dehydration on balance in euthermic individuals employing the Balance Error Scoring System (BESS). The results indicate that dehydration significantly negatively affects balance

The Supreme Court, Democracy and Institutional Reform Litigation

In an unexpected portion of its unanimous opinion in Frew v. Hawkins, 540 U.S. 431 (2004), the SupremeCourt broke new ground on an important question involving consent decrees. The case began when Texas state officials invoked the Eleventh Amendment in their resistance to a federal Medicaid consent decree. TheCourt quickly disposed of that argument, but Justice Anthony Kennedy, writing for the unanimous Court,took the opportunity to forcefully state that consent decrees that intrude on the policy making prerogatives of state and local officials more than is necessary to protect rights undercut the effective functioning of elected state and local governments. In that context Justice Kennedy broadly discussed the Court\u27s rulings on modifications of consent decrees. In this essay, we argue that Frew significantly eased the standards for modification of consent decrees previously set out in Rufo v. Inmates of Suffolk County Jail. Frew as a whole received little attention and thepart of it easing modification seems to have received no notice at all. It is, however, possible to gauge thereaction it will produce from the reaction to our book, Democracy by Decree: What Happens When Courts Run Government (Yale U. Press, 2003). The book came out a year before Frew, proposed the kind of easing adapted by that case, and explained it in terms similar to that stated by the Supreme Court. In this essay, we reply at once to Frew\u27s potential critics and our actual critics. Citing our book and Frew, a bi-partisan group of senators and representatives introduced this spring theFederal Consent Decree Fairness Act. The act would not affect the power of federal courts to approve consent decrees, but would allow state and local defendants to more easily get decrees modified or vacated when thedecrees are no longer necessary to protect rights. The bill was the subject of hearings in the House on June 21 and in the Senate on July 19, 2005