Organizations Focused On Immigrant Civic Participation Encourage Immigrants To Be Part of the Broader Community

The first year evaluation report on the Immigrant Participation & Immigration Reform (IPIR) initiative tells a story of human and social development -- newcomers joining and strengthening the democracy-among immigrants whose institutions engage them in organizational self-governance, leadership opportunities, and democratic civic activity. Indeed, evidence suggests that it is the quality of these organizations that draws immigrants into participation: Sixty-three percent of respondents said that one of their major motivations to be active in the community was that "I like being a part of an organization that does good work.

Creative Aging in America's Libraries: Year Two Evaluation Report

Creative Aging in America's Libraries is a three-year national leadership initiative to improve, expand and sustain Creative Aging programming in public libraries. It was designed and is led by Lifetime Arts, Inc., in partnership with Westchester Library System. Major support is provided by the Institute for Museum and Library Services. Twenty library systems across the country (listed in Appendix A) are participating in this initiative. The initiative began in the spring of 2014 with a preparation phase, equipping participating libraries to plan and conduct instructional arts programs for older adults according to the model developed by Lifetime Arts. Activities included a series of webinars; a pair of three-day regional training institutes (one in the east, one in the west) to which each library system sent a team of up to five librarians and administrators; launch of a Wikispace where participants can raise questions, exchange information and engage in peer learning and mutual support; access to Lifetime Arts' online resources; and customized assistance from Lifetime Arts staff. The second phase, implementation, began in late 2014 and runs through mid-2016. During this phase, each system is conducting between two and five Creative Aging programs, with support from Lifetime Arts. Goals are to demonstrate and evaluate the model including testing any local variations, build capacity, and begin building sustainability for this kind of programming. Altogether, 67 Creative Aging programs are planned across the 20 systems (plus additional programs in several systems conducted with funding from other sources). A final phase, from July through December 2016, will analyze final results and lessons from all sites, and do further exploration and planning to sustain and expand libraries' Creative Aging activities into the future

Faith, Community and Civic Action: Reflections on the Organized Religion Initiative

Evaluates how well six California faith-based institutions used community organizing to pull immigrant and low-income communities into more active involvement with political and civic leadership and participation activities, between 1996-2005

Strengthening Grassroots Community Leadership in Detroit

Community Connections is a resident-centered grant program working to strengthen civic engagement and grassroots leadership in six Detroit neighborhoods: Brightmoor, Chadsey Condon, Cody Rouge, North End, Osborn, and Southwest. It awards grants of $500 to$5,000 to local projects that mobilize residents' energies to improve opportunities and conditions for youth. Community Connections was launched by the Skillman Foundation in 2006 as part of the Foundation's Good Neighborhoods initiative, and is operated by Prevention Network, a statewide organization experienced in running resident-focused small grants programs. Since 2012 it has also received major support from the W. K. Kellogg Foundation.Rooted in the conviction that local groups and leaders are essential if neighborhoods are to create safe environments where children and youth can grow up successfully, the program is guided by a four-fold impact framework. At its heart is a commitment to expand residents' civic engagement. Through its project support and related learning opportunities, Community Connections helps strengthen community leadership in these neighborhoods. Projects offer positive youth development opportunities to children and teens in these neighborhoods. And some projects contribute to systems change by connecting with kids in ways that larger institutional systems currently miss, by helping to create alternatives to those established institutional systems, and by engaging in neighborhood planning, policy advocacy and other efforts to reform those systems

Organized Religion Initiative: What's Faith Got to Do With It?

Offers insights from Irvine's work with six California faith-based civic engagement projects. Describes a framework for differentiating faith-based models, and examines what motivates the move from congregation leader to community leadership

Vitrectomy-Assisted Biopsy: An in vitro Study on the Impact of Cut Rate and Probe Size

Purpose: The aim of this study was to optimize the technique of performing vitrectomy-assisted biopsy of intraocular tumors by comparing the cytohistological findings in specimens obtained with different vitrectomy probes and cut rates. Methods: Vitrectomy-assisted biopsies were taken from a fresh porcine liver. For each sampling, the vacuum level was 300 mm Hg. The following parameters were compared; cut rate (60, 600 and 6,000 cuts per minute [cpm]), probe type (standard and two-dimensional cutting [TDC]), and probe diameter (23-gauge and 25-gauge). The specimens were assessed by automated whole-slide imaging analysis and conventional light microscopy. Results: Seventy-two biopsies were analyzed for the number of hepatocytes, total area of tissue fragments, and total stained area of each microscope slide. For all probe types, these parameters were significantly and positively correlated with the cut rate. TDC probes led to significantly higher scores than those of standard probes, independent of the cut rate. There were no significant differences in results when using 23-gauge or 25-gauge standard probes. Light microscopic examination demonstrated well-preserved cells sufficient for cytohistological analyses in all investigated cases. Conclusions: The higher the cut rate, the larger is the amount of aspirated cellular material. There were no significant differences between 23-gauge and 25-gauge biopsies. Cut rates up to 6,000 cpm did not adversely affect the cytohistological features of the samples.acceptedVersio

Genetic alterations associated with malignant transformation of sporadic vestibular schwannoma

Introduction: Malignant peripheral nerve sheath tumor of the vestibulocochlear nerve (VN-MPNST) is exceedingly rare and carries a poor prognosis. Little is known about its underlying genetics and in particular the process of malignant transformation. There is an ongoing debate on whether the transformation is initiated by ionizing radiation. We present here the analysis and comparison of two post-radiation VN-MPNST and one undergoing spontaneous transformation. Methods: Four tumors from three patients (radiation-naïve vestibular schwannoma before (VS) and after (VN-MPNST) malignant transformation in addition to two post-radiation VN-MPNST) were subjected to DNA whole-genome microarray and whole-exome sequencing and tumor-specific mutations were called. Mutational signatures were characterized using MuSiCa. Results: The tumor genomes were characterized predominantly by copy-number aberrations with 36–81% of the genome affected. Even the VS genome was grossly aberrated. The spontaneous malignant transformation was characterized by a near-total whole-genome doubling, disappearance of NF2 mutation and new mutations in three cancer-related genes (GNAQ, FOXO4 and PDGFRB). All tumors had homozygous loss of the tumor suppressor CDKN2A. Neither mutational signature nor copy number profile was associated with ionizing radiation. Conclusion: The VN-MPNST genome in our cases is characterized by large copy-number aberrations and homozygous deletion of CDKN2A. Our study demonstrates a VS with genetic alterations similar to its malignant counterpart, suggesting the existence of premalignant VS. No consistent mutational signature was associated with ionizing radiation.publishedVersio

Direct Observation and Analysis of Low-Energy Magnons with Raman Spectroscopy in Atomically Thin NiPS3

Van der Waals (vdW) magnets have rapidly emerged as a fertile playground for novel fundamental physics and exciting applications. Despite the impressive developments over the past few years, technical limitations pose a severe challenge to many other potential breakthroughs. High on the list is the lack of suitable experimental tools for studying spin dynamics on atomically thin samples. Here, Raman scattering techniques are employed to observe directly the low-lying magnon (~1 meV) even in bilayer NiPS3. The unique advantage is that it offers excellent energy resolutions far better on low-energy sides than most inelastic neutron spectrometers can offer. More importantly, with appropriate theoretical analysis, the polarization dependence of the Raman scattering by those low-lying magnons also provides otherwise hidden information on the dominant spin-exchange scattering paths for different magnons. By comparing with high-resolution inelastic neutron scattering data, these low-energy Raman modes are confirmed to be indeed of magnon origin. Because of the different scattering mechanisms involved in inelastic neutron and Raman scattering, this new information is fundamental in pinning down the final spin Hamiltonian. This work demonstrates the capability of Raman spectroscopy to probe the genuine two-dimensional spin dynamics in atomically-thin vdW magnets, which can provide novel insights that are obscured in bulk spin dynamics.Comment: 37 pages, 5 figures, supplementary information 11 page