1,931 research outputs found

    Transdermal delivery of ibuprofen utilizing a novel solvent free pressure sensitive adhesive (PSA) : TEPI® technology

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    Purpose The main objective of this present study was the investigation of potential novel transdermal patch technology (TEPI®) delivering ibuprofen as the active pharmaceutical ingredient (API) using a novel poly(ether-urethane)-silicone crosslinked pressure-sensitive adhesive (PSA) as the drug reservoir in a solvent-free manufacturing process. Methods The patch was synthesized utilizing the hot-melt crosslinking technique without the addition of solvents at 80 °C in 100% relative humidity. Dissolution and permeation studies performed utilizing diffusion cells and subsequently HPLC validated methods were employed to determine the API content in the acceptor solution. Accelerated stability studies were also performed at 40 °C and 70% relative humidity. The adhesive performance of the fabricated patch was evaluated utilizing loop tack adhesion tests. Results In vitro permeation experiments across both Strat-M® and human skin demonstrated that ibuprofen can easily be released from the adhesive matrix and penetrate through the studied membrane. A comparison on the permeation rates of the API across the two membranes indicated that there is not a strong correlation between the obtained data. The presence of chemical enhancers facilitated an increased flux of the API higher than observed in the basic formulation. Initial stability studies of the optimized formulation showed no degradation with respect to the drug content. Adhesion studies were also performed indicating higher values when compared with commercially available products. Conclusions The present study demonstrated the fabrication of an ibuprofen patch utilizing a versatile, solvent-free drug delivery platform. Upon optimization of the final system, the resulting patch offers many advantages compared to commercially available formulations including high drug loading (up to 25 wt%), good adhesion, and painless removal leaving no residues on the skin. This PSA offers many advantages over existing adhesive technology

    Latin American Liberation Theology

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    David Tombs offers an accessible introduction to the theological challenges raised by Latin American Liberation from its emergence in the 1960s to its ‘decade of crisis’ in the 1990s. This work traces the distinct developments of liberation thought through the decades, and is crucial to understanding liberation theology and its legacies.; Readership: All who are interested in church history, Latin American studies and the emergence of political and contextual Christian theologies over the last four decades

    Chapter 3 Unspeakable Violence

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    This book examines the recent phenomenon in Latin America of national Truth and Reconciliation commissions. Few studies have examined the role of Churches or religion in political processes that proclaim valued theological terms as their agenda - truth, forgiveness, and reconciliation. This book questions the role of religion, specifically of established Churches. The impact of such reconciliation commissions on Indigenous Native Americans is also examined, as is the role of women and how both commissions and Churches or religions were challenged by their experiences. The contributors offer differing perspectives on one or more national truth and reconciliation processes and thus offer a collection that serves as valuable source for the disciplines of Religious Studies, Ethics, Theology, Political Science, Social Sciences and Women's Studies

    Chapter 3 Unspeakable Violence

    Get PDF
    This book examines the recent phenomenon in Latin America of national Truth and Reconciliation commissions. Few studies have examined the role of Churches or religion in political processes that proclaim valued theological terms as their agenda - truth, forgiveness, and reconciliation. This book questions the role of religion, specifically of established Churches. The impact of such reconciliation commissions on Indigenous Native Americans is also examined, as is the role of women and how both commissions and Churches or religions were challenged by their experiences. The contributors offer differing perspectives on one or more national truth and reconciliation processes and thus offer a collection that serves as valuable source for the disciplines of Religious Studies, Ethics, Theology, Political Science, Social Sciences and Women's Studies

    The Crucifixion of Jesus

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    Roman crucifixions sought to degrade and dehumanise their victims in ways that destroyed their dignity and stigmatised their memory. Paul speaks of the cross as a ‘scandal’ or ‘stumbling block’, but the significance of this language has never been explored in terms of sexual violence. The Crucifixion of Jesus examines crucifixion as a form of torture, state terror, and sexual abuse. It reads recent accounts of torture alongside the presentation of crucifixion in the Passion narratives and other Greek and Roman sources. Outlining compelling reasons for viewing Jesus as a victim of sexual abuse, it examines why this unsettling aspect of the narrative has remained ‘hidden in plain sight’ for so long, and what place it might have in discussions of rape culture past and present. It also asks whether other acts of sexual violence and rape might have happened during the mockery in the praetorium, or even on the cross itself. It argues that although the acknowledgement of this ‘unspeakable violence’ is deeply disturbing, breaking the silence can nonetheless have constructive consequences. In addition to offering a more historical understanding of crucifixion, this book illuminates positive new aspects of resurrection, making it a probing read for scholars of biblical studies and for those interested in the interplay of religion and violence

    Latin American Liberation Theology

    Get PDF
    David Tombs offers an accessible introduction to the theological challenges raised by Latin American Liberation from its emergence in the 1960s to its ‘decade of crisis’ in the 1990s. This work traces the distinct developments of liberation thought through the decades, and is crucial to understanding liberation theology and its legacies.; Readership: All who are interested in church history, Latin American studies and the emergence of political and contextual Christian theologies over the last four decades

    An evaluation of implementing problem-based learning scenarios in an immersive virtual world

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    Objectives: This paper will describe a project adopting a pedagogical approach that implemented and evaluated a problem-based learning project in an immersive virtual world. The project involved an iterative process of testing scenarios using student feedback to improve upon the scenarios Methods: The study used illuminative evaluation which is argued to take account of wider contexts than more tradi-tional evaluation and, is primarily concerned with descrip-tion and interpretation rather than measurement and prediction. The evaluation encompassed formative elements to inform the project team and summative elements to establish the worth of what was achieved. Results: The findings in many ways were more positive than initially anticipated, but there were also a number of challenges. The themes that emerged for the data were technological challenges, pedagogical design, usability and avatar identity, collaboration and Interaction. Conclusions: Students appreciated the value of Second Life as a collaborative environment, but also viewed such practice-based simulations as valuable for individual work. An interesting consequence of the richness and authenticity of the Second Life scenarios is the large amount of detail provided, much more than is usual in paper-based face-to face problem-based learning session

    A deadly consensus: worker safety and regulatory degradation under New Labour

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    This paper documents the vulnerability of the UK workplace safety regime to ‘regulatory degradation’. Following a brief overview of this regime, the paper examines the dominant arguments within academic literature on appropriate and feasible regulatory enforcement, arguing that the approaches to regulation thereby advocated have been easily degraded as a result of their compatibility with neo-liberal economic strategy. A subsequent analysis of empirical trends within safety enforcement reveals a virtual collapse of formal enforcement, as political and resource pressures have taken their toll on the regulatory authority. Finally, the paper indicates that the increasing impunity with which employers can kill and injure is particularly problematic as we enter sustained economic recession, and underlines the urgent need for regulatory alternatives
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