Detection of Leishmania infantum by PCR, serology and cellular immune response in a cohort study of Brazilian dogs

The sensitivity and specificity of PCR, serology (ELISA) and lymphoproliferative response to Leishmania antigen for the detection of Leishmania infantum infection were evaluated in a cohort of 126 dogs exposed to natural infection in Brazil. For PCR, Leishmania DNA from bone-marrow was amplified with both minicircle and ribosomal primers. The infection status and time of infection of each dog were estimated from longitudinal data. The sensitivity of PCR in parasite-positive samples was 98%. However, the overall sensitivity of PCR in post-infection samples, from dogs with confirmed infection, was only 68%. The sensitivity of PCR varied during the course of infection, being highest (78–88%) 0–135 days post-infection and declining to around 50% after 300 days. The sensitivity of PCR also varied between dogs, and was highest in sick dogs. The sensitivity of serology was similar in parasite-positive (84%), PCR-positive (86%) and post-infection (88%) samples. The sensitivity of serology varied during the course of infection, being lowest at the time of infection and high (93–100%) thereafter. Problems in determining the specificity of serology are discussed. The sensitivity and specificity of cellular responsiveness were low. These data suggest that PCR is most useful in detecting active or symptomatic infection, and that serology can be a more sensitive technique for the detection of all infected dogs

Charged lepton contributions to the solar neutrino mixing and theta_13

A charged lepton contribution to the solar neutrino mixing induces a contribution to theta_13, barring cancellations/correlations, which is independent of the model building options in the neutrino sector. We illustrate two robust arguments for that contribution to be within the expected sensitivity of high intensity neutrino beam experiments. We find that the case in which the neutrino sector gives rise to a maximal solar angle (the natural situation if the hierarchy is inverse) leads to a theta_13 close to or exceeding the experimental bound depending on the precise values of theta_12, theta_23, an unknown phase and possible additional contributions. We finally discuss the possibility that the solar angle originates predominantly in the charged lepton sector. We find that the construction of a model of this sort is more complicated. We comment on a recent example of natural model of this type.Comment: 10 pages, 1 figur

After accommodation? Inclusion and exclusion of emancipation interests in Dutch ‘democratic corporatism’

One form of accommodating historically marginalised social groups is through ‘democratic corporatism’, in which government to some degree formalises emancipation interests’ representation within policy processes. This article compares the corporatist trajectories of the emancipation interests of women and gays/lesbians in the Netherlands to examine why women’s interests became excluded from and gay/lesbian interests remained included in corporatist policy processes. Existing studies have failed to explain why changes in corporatism differently affect incorporated organisations across policy arenas. This article examines the role of the level of formalisation of corporatist relations, and by extension the ability of incorporated organisations to combine top-down and bottom-up resources, in leading to exclusion from or continued inclusion in corporatist policy processes. The findings highlight the importance for incorporated emancipation interests of the ability to combine top-down and bottom-up resources to manoeuvre changes in corporatism and successfully maintain their inclusion in corporatist policy processes

Strategic Tradeoffs:Movement-government interactions and Dutch gay and lesbian policy, 1986-1994

Interactions between social movements and government actors have been conceptualized as either combative and exclusionary or institutionalized and coopted. This article transcends that dichotomy by tracing one social movement organization's tactical pursuit of institutionalization, examining the process through which institutionalization occurred, and evaluating its effects. This case study, based on qualitative, archival data, traces the institutionalization of the gay and lesbian social movement organization, the Dutch Association for the Integration of Homosexuality, COC, between 1986 and 1994. The analysis offers three findings: First, institutionalization is a process built through sustained exchange relations over time. Second, institutionalization does not necessarily result in cooptation but does involve tradeoffs. Third, both SMO and governmental actors are affected, albeit differently, by the process of institutionalization. While the COC was primarily affected organizationally, the Dutch government became more activist by attempting to influence the social institution of sexuality to accommodate homosexuality

On the reheating stage after inflation

We point out that inflaton decay products acquire plasma masses during the reheating phase following inflation. The plasma masses may render inflaton decay kinematicaly forbidden, causing the temperature to remain frozen for a period at a plateau value. We show that the final reheating temperature may be uniquely determined by the inflaton mass, and may not depend on its coupling. Our findings have important implications for the thermal production of dangerous relics during reheating (e.g., gravitinos), for extracting bounds on particle physics models of inflation from Cosmic Microwave Background anisotropy data, for the production of massive dark matter candidates during reheating, and for models of baryogenesis or leptogensis where massive particles are produced during reheating.Comment: 8 pages, 2 figures. Submitted for publication in Phys. Rev.

Computational Nuclear Physics and Post Hartree-Fock Methods

We present a computational approach to infinite nuclear matter employing Hartree-Fock theory, many-body perturbation theory and coupled cluster theory. These lectures are closely linked with those of chapters 9, 10 and 11 and serve as input for the correlation functions employed in Monte Carlo calculations in chapter 9, the in-medium similarity renormalization group theory of dense fermionic systems of chapter 10 and the Green's function approach in chapter 11. We provide extensive code examples and benchmark calculations, allowing thereby an eventual reader to start writing her/his own codes. We start with an object-oriented serial code and end with discussions on strategies for porting the code to present and planned high-performance computing facilities.Comment: 82 pages, to appear in Lecture Notes in Physics (Springer), "An advanced course in computational nuclear physics: Bridging the scales from quarks to neutron stars", M. Hjorth-Jensen, M. P. Lombardo, U. van Kolck, Editor