The hardwiring of development: Organization and function of genomic regulatory systems

The gene regulatory apparatus that directs development is encoded in the DNA, in the form of organized arrays of transcription factor target sites. Genes are regulated by interactions with multiple transcription factors and the target sites for the transcription factors required for the control of each gene constitute its cis-regulatory system. These systems are remarkably complex. Their hardwired internal organization enables them to behave as genomic information processing systems. Developmental gene regulatory networks consist of the cis-regulatory systems of all the relevant genes and the regulatory linkages amongst them. Though there is yet little explicit information, some general properties of genomic regulatory networks have become apparent. The key to understanding how genomic regulatory networks are organized, and how they work, lies in experimental analysis of cis-regulatory systems at all levels of the regulatory network

Phenomenological Consequences of Soft Leptogenesis

Soft supersymmetry breaking terms involving heavy singlet sneutrinos can be the dominant source of leptogenesis. The relevant range of parameters is different from standard leptogenesis: a lighter Majorana mass, M < 10^9 GeV (allowing a solution of the gravitino problem), and smaller Yukawa couplings, Y_N < 10^{-4}. We investigate whether the various couplings of the singlet sneutrinos, which are constrained by the requirement of successful `soft leptogenesis', can have observable phenomenological consequences. Specifically, we calculate the contributions of the relevant soft supersymmetric breaking terms to the electric dipole moments of the charged leptons and to lepton flavor violating decays. Our result is that these contributions are small.Comment: 11 pages, 1 figure; v2: an additional contribution is considered (modifying: fig. 1, eq. 10-13, 22) and a reference added. Conclusions unchange

A compact spectroradiometer for solar simulator measurements

Compact spectral irradiance probe has been designed and built which uses wedge filter in conjunction with silicon cell and operational amplifier. Probe is used to monitor spectral energy distribution of solar simulators and other high intensity sources

Sidewise dispersion relations and the structure of the nucleon vertex

We revisit sidewise dispersion relations as a method to relate the nucleon off-shell form factor to observable quantities, namely the meson-nucleon scattering phase shifts. It is shown how for meson-nucleon scattering a redefinition of the intermediate fields leaves the scattering amplitude invariant, but changes the behavior of the off-shell form factor as expressed through dispersion relations, thus showing representation dependence. We also employ a coupled-channel unitary model to test the validity of approximations concerning the influence of inelastic channels in the sidewise dispersion relation method.Comment: 29 pages. Uuencoded gz-compressed tar file; includes RevTeX source plus 3 postscript figures incorporated with epsfig.sty plus 3 LaTeX figures using eepic.sty (included). Complete postscript file available via WWW at http://www.nikhefk.nikhef.nl/projects/Theory/preprints/preprints.htm

Hollowgraphy Driven Holography: Black Hole with Vanishing Volume Interior

Hawking-Bekenstein entropy formula seems to tell us that no quantum degrees of freedom can reside in the interior of a black hole. We suggest that this is a consequence of the fact that the volume of any interior sphere of finite surface area simply vanishes. Obviously, this is not the case in general relativity. However, we show that such a phenomenon does occur in various gravitational theories which admit a spontaneously induced general relativity. In such theories, due to a phase transition (one parameter family degenerates) which takes place precisely at the would have been horizon, the recovered exterior Schwarzschild solution connects, by means of a self-similar transition profile, with a novel 'hollow' interior exhibiting a vanishing spatial volume and a locally varying Newton constant. This constitutes the so-called 'hollowgraphy' driven holography.Comment: Honorable Mention Essay - Gravity Research Foundation (2010

Sequence organization of feline leukemis virus DNA in infected cells

A restriction site map has been deduced of unintegrated and integrated FeLV viral DNA found in human RD cells after experimental infection with the Gardner-Arnstein strain of FeLV. Restriction fragments were ordered by single and double enzyme digests followed by Southern transfer (1) and hybridization with 32P-labeled viral cDNA probes. The restriction map was oriented with respect to the 5' and 3' ends of viral RNA by using a 3' specific hybridization probe. The major form of unintegrated viral DNA found was a 8.7 kb linear DNA molecule bearing a 450 bp direct long terminal redundancy (LTR) derived from both 5' and 3' viral RNA sequences. Minor, circular forms, 8.7 kb and 8.2 kb in length were also detected, the larger one probably containing two adjacent copies of the LTR and the smaller one containing one copy of the LTR. Integrated copies of FeLV are colinear with the unintegrated linear form and contain the KpnI and SmaI sites found in each LTR

The generalized Fenyes-Nelson model for free scalar field theory

The generalized Fenyes--Nelson model of quantum mechanics is applied to the free scalar field. The resulting Markov field is equivalent to the Euclidean Markov field with the times scaled by a common factor which depends on the diffusion parameter. This result is consistent between Guerra's earlier work on stochastic quantization of scalar fields. It suggests a deep connection between Euclidean field theory and the stochastic interpretation of quantum mechanics. The question of Lorentz covariance is also discussed.Comment: 6 page