Cocoons as a space of their own: a case of Emirati women learners

© 2017 Informa UK Limited, trading as Taylor & Francis Group. This article focuses on ‘cocooning’ as a spatial practice of Emirati higher education women learners in a single-sex learning context, which emerged from exploring the intersectional and intertwined relationship of gender, place and culture with its unique cultural formation that informs women learners’ spatiality. To understand women’s spatiality and explore these intersecting relations, I conducted an ethnographic qualitative inquiry, applying multiple levels of data gathering and analysis. I also utilised social theories of space as a theoretical framework, specifically the social construction of space and Lefebvre’s triad of perceived, conceived and lived space. Cocooning, represented in these women learners’ unique spatial appropriation in their quest for a space of their own, emerged as a pervasive socially constructed spatial theme. As a spatial practice, it was largely influenced by the women learners’ cultural model, including socio-cultural status and gender roles, rooted in their national, historical colonial and traditional past as well as current economic, political, demographic, academic-institutional and global positions and demands. Furthermore, cocooning is a spatial representation of what also seems a universal longing among women, beyond context and culture, for a space of one’s own. Such a spatial need is manifested differently in the perceived space while shared in the conceived and lived

Stratified analyses refine association between TLR7 rare variants and severe COVID-19

Summary: Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 variants were present in 2.4% of young (<60 years) cases with no reported clinical risk factors (n = 378), compared to 0.24% of controls (odds ratio [OR] = 12.3, p = 1.27 × 10−10). Incorporation of the results of either functional assays or protein modeling led to a pronounced increase in effect size (ORmax = 46.5, p = 1.74 × 10−15). Association signals for the X-chromosomal gene TLR7 were also detected in the female-only subgroup, suggesting the existence of additional mechanisms beyond X-linked recessive inheritance in males. Additionally, supporting evidence was generated for a contribution to severe COVID-19 of the previously implicated genes IFNAR2, IFIH1, and TBK1. Our results refine the genetic contribution of rare TLR7 variants to severe COVID-19 and strengthen evidence for the etiological relevance of genes in the interferon signaling pathway