Antimicrobial Evaluation of Dichloro Chromene Isoxazoles and Isoxazoline Derivatives

In the present study, the synthesized benzopyran isoxazolines and isoxazoles were evaluated for antibacterial activity by Agar well diffusion method against multi drug resistance (MDR) clinical isolates of five bacterial strains.i.e., Staphylococcus sp. (2413), Enterococcus sp. (2449), and Escherichia sp. (2461), Acinetobacter sp. (2457) and Serratia sp (2442). MIC (Minimum inhibitory concentration) and MBC (Minimum bactericidal concentration) of the potent derivatives were calculated and tabulated. A partial structure activity relationship (SAR) was done on the basis of microbial inhibition data. Compounds 3, 6, 8, 9, 11, 14 and 20 were the most promising antibacterial molecule. Compound 3, the precursor of isoxazole / isoxazoline found to be most active antibacterial candidate as well as bactericidal too

Diastereoselective synthesis of highly functionalized cis-1-oxadecalines via 6-endo-tet-cyclizations of 2-C-branched sugars

Diastereoselective synthesis of highly functionalizedcis-1-oxadecalinesvia6-endo-tet-cyclizations of 2-C-branched sugars.</p

Cross dehydrogenative coupling of sugar enol ethers with terminal alkenes in the synthesis of pseudo-disaccharides, chiral oxadecalins and a conjugated triene

An efficient strategy for the synthesis of C-2 and C-3 branched sugar dienes via cross dehydrogenative coupling of sugar enol ethers with terminal alkenes was developed.</p

Stereoselective Construction of Orthogonally Protected, N–O Interlinked Disaccharide Mimetics Using N‑Substituted β‑Aminooxy Donors

Orthogonally protected N-substituted β-aminooxy sugars can be stereoselectively synthesized from sugar epoxides and nitrones derived from aromatic aldehydes. Both the ether- and ester-protected sugar epoxides can be employed. The synthesized aminooxy sugars could be reacted with aldehyde bearing/free reducing sugars under the heating condition to afford N–O-linked 1,1-/1,5/1,6-disaccharide mimetics in a good yield