3,564 research outputs found
Once Were Science Teachers
This paper explores the development of three pre-service science teacher educators\u27 understandings of some critical incidents in their development of science teachers that has impacted on the manner in which they teach about teaching in a teacher preparation program. The study draws on self-study methodology by situating their reflection on practice within a critical discourse whereby reframing has been important in learning through a reconsideration from particular critical incidents in their high school science teaching experiences. The authors argue that through critical reflection on practice, as illustrated in this paper, that the beginnings of the articulation and documentation of a knowledge base of teaching about teaching might be initiated. They therefore offer some of their emerging views on what that knowledge base might encompass through some assertions of practice that they believe impact on their teaching about teaching
Investing in Children Reports: Investment advice to commissioners of services in areas of Youth Justice, Education and Child Protection
The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process
Caspase family proteases play important roles in the regulation of apoptotic cell death. Initiator caspases are activated in response to death stimuli, and they transduce and amplify these signals by cleaving and thereby activating effector caspases. In Drosophila, the initiator caspase Nc (previously Dronc) cleaves and activates two short-prodomain caspases, Dcp-1 and Ice (previously Drice), suggesting these as candidate effectors of Nc killing activity. dcp-1-null mutants are healthy and possess few defects in normally occurring cell death. To explore roles for Ice in cell death, we generated and characterized an Ice null mutant. Animals lacking Ice show a number of defects in cell death, including those that occur during embryonic development, as well as during formation of adult eyes, arista and wings. Ice mutants exhibit subtle defects in the destruction of larval tissues, and do not prevent destruction of salivary glands during metamorphosis. Cells from Ice animals are also markedly resistant to several stresses, including X-irradiation and inhibition of protein synthesis. Mutations in Ice also suppress cell death that is induced by expression of Rpr, Wrinkled (previously Hid) and Grim. These observations demonstrate that Ice plays an important non-redundant role as a cell death effector. Finally, we demonstrate that Ice participates in, but is not absolutely required for, the non-apoptotic process of spermatid differentiation
Requisite endothelial reactivation and effective siRNA nanoparticle targeting of Etv2/Er71 in tumor angiogenesis
A Mother\u27s Trauma in the Face of Child Removal
The crisis of the involuntary removal of a child from their parent can be traumatic for both child and parent. A child’s biological mother who is undergoing the process of removal experiences a traumatic event as she feels a range of emotions. Those emotions cause depression, loss, and emotional shock that can dissociate the mother from her goal and priority of reunification with her child. Research has been limited concerning parent’s perceptions and experiences of removal with most studies being conducted emphasizing trauma for the child. The purpose of this phenomenological qualitative study is to understand the impact of trauma levels with mothers whose children have been or are currently removed from their care by social services and to explore their needs for sources of support to benefit them during this time. This study will be rooted in psychological trauma theory as developed by Pierre Janet and how trauma affects the mother during the removal process. Data collection will follow the conceptual mapping task process, utilizing interviews with participants, and data analysis will be conducted under that same framework while grouping themes together in context. Multiple contextual factors also come into play hindering a parent from learning parenting responsibilities and regaining custody of the child. Partnerships with social services and child protective services can go a long way to ensure the parent recovers from the trauma of removal and develops a healthier relationship with support systems
Coronary CT Angiography and 5-Year Risk of Myocardial Infarction.
BACKGROUND: Although coronary computed tomographic angiography (CTA) improves diagnostic certainty in the assessment of patients with stable chest pain, its effect on 5-year clinical outcomes is unknown. METHODS: In an open-label, multicenter, parallel-group trial, we randomly assigned 4146 patients with stable chest pain who had been referred to a cardiology clinic for evaluation to standard care plus CTA (2073 patients) or to standard care alone (2073 patients). Investigations, treatments, and clinical outcomes were assessed over 3 to 7 years of follow-up. The primary end point was death from coronary heart disease or nonfatal myocardial infarction at 5 years. RESULTS: The median duration of follow-up was 4.8 years, which yielded 20,254 patient-years of follow-up. The 5-year rate of the primary end point was lower in the CTA group than in the standard-care group (2.3% [48 patients] vs. 3.9% [81 patients]; hazard ratio, 0.59; 95% confidence interval [CI], 0.41 to 0.84; P=0.004). Although the rates of invasive coronary angiography and coronary revascularization were higher in the CTA group than in the standard-care group in the first few months of follow-up, overall rates were similar at 5 years: invasive coronary angiography was performed in 491 patients in the CTA group and in 502 patients in the standard-care group (hazard ratio, 1.00; 95% CI, 0.88 to 1.13), and coronary revascularization was performed in 279 patients in the CTA group and in 267 in the standard-care group (hazard ratio, 1.07; 95% CI, 0.91 to 1.27). However, more preventive therapies were initiated in patients in the CTA group (odds ratio, 1.40; 95% CI, 1.19 to 1.65), as were more antianginal therapies (odds ratio, 1.27; 95% CI, 1.05 to 1.54). There were no significant between-group differences in the rates of cardiovascular or noncardiovascular deaths or deaths from any cause. CONCLUSIONS: In this trial, the use of CTA in addition to standard care in patients with stable chest pain resulted in a significantly lower rate of death from coronary heart disease or nonfatal myocardial infarction at 5 years than standard care alone, without resulting in a significantly higher rate of coronary angiography or coronary revascularization. (Funded by the Scottish Government Chief Scientist Office and others; SCOT-HEART ClinicalTrials.gov number, NCT01149590 .)
Aquaculture development in Scotland:regulation as a moving equilibrium
The expanding interest in marine planning and management raises important questions for the spectrum of marine, coastal and terrestrial environments. The role of state regulation in mediating conflicts over the use and development of the marine resource has spatial implications across these domains. Governance of the marine represents a very particular challenge since it involves a highly complex mix of common, legal and customary property rights and sets of defined territorial jurisdictions. The Planning etc. (Scotland) Act 2006 and subsequent policy iterations have changed institutional and organizational relations. The legislation included provisions for the extension of statutory land use planning controls to include coastal and transitional waters (i.e. to the 12-nautical mile limit), meaning that finfish and shellfish farming are subject to the terrestrial planning regime. This represents a turn from self-regulation to arrangements for state planning controls. This paper traces this evolution in terms of a moving equilibrium as both state and market have sought to minimize the transaction costs involved
Using workplace population statistics to understand retail store performance
We explore the value of recently released workplace geographies and accompanying census-based workplace zone statistics (WZS) and an associated classification of workplace zones (COWZ). We consider how these data could support retailers in their operational and strategic decision making, including the evaluation of retail demand and retail store performance in localities where trade is driven by non-residential demand. In collaboration with major UK grocery retailer ‘The Co-operative Group’ we explore the relationship between workplace population composition and store trading characteristics using a series of case study stores within Inner London. We use empirical store trading data to identify store and product category level temporal sales fluctuations attributable to workplace populations. We also use census-derived flow data to identify the spatial origins of workplace population inflow. We identify that store performance exhibits characteristics attributable to demand driven by these populations. We conclude that workplace population geographies, WZS and the COWZ afford considerable potential for understanding drivers of store performance, observed store trading patterns and evaluation of retail store performance. We suggest that the next step is to build these populations and their micro geography spatial and temporal characteristics into predictive models and evaluate their potential for store performance evaluation and location-based store and network decision making within this sector
Hybridization in parasites: consequences for adaptive evolution, pathogenesis and public health in a changing world
[No abstract available
Barriers to recycling plastics from the perspectives of industry stakeholders
Previous research exploring the psychological, social, and environmental barriers to recycling has predominantly focused on consumer attitude and behaviour. However, the plastic system involves a chain of stakeholders with a role in decision-making and actions in relation to plastic production and management post-use, affirming the need to explore the barriers to recycle across various other stakeholders implicated in the lifecycle of plastic product and packaging. To expand this evidence-base, N = 12 in-depth qualitative semi-structured interviews explored the perspectives of some of the stakeholders responsible for various aspects of the plastic life cycle (fast moving consumer goods industry, retailers, and waste management professionals). Using a semi-directed content analysis approach via NVivo, three overarching themes were extracted from the data: 1) Disempowerment and lost opportunities 2) Solutions and opportunities reside with use of legislation 3) The circular economy stakeholders need motivation, and to be more knowledgeable. The themes suggest that stakeholders implicated in the plastic lifecycle lack the drive and perceived personal and organizational efficacy to generate meaningful change in the plastic system. These barriers are exacerbated by a lack of collegial partnerships between stakeholders to facilitate knowledge transfer and collective action. This study recommends greater collaboration and communication between stakeholders implicated in the end-to-end plastic “chain”, and makes a renewed call for further legislation, having shed light on important socio-political and pragmatic barriers to reducing plastic waste
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