Structural response to O*-O' and magnetic transitions in orthorhombic perovskites

We present a temperature dependent single crystal x-ray diffraction study of twinned orthorhombic perovskites La1-xCaxMnO3, for x=0.16 and x=0.25. These data show the evolution of the crystal structure from the ferromagnetic insulating state to the ferromagnetic metallic state. The data are modelled in space group Pnma with twin relations based on a distribution of the b axis over three perpendicular cubic axes. The twin model allows full structure determination in the presence of up to six twin fractions using the single crystal x-ray diffraction data.Comment: 13 pages, including 13 figures and 2 table

A Pre-Registered Test of a Correlational Micro-PK Effect: Efforts to Learn from a Failure to "Replicate"

Micro-psychokinesis (micro-PK) research studies the effects of observers' conscious or unconscious intentions on random outcomes derived from true random sources such as quantum random number generators (QRNGs). The micro-PK study presented here was originally planned, preregistered, and conducted to exactly replicate a correlational finding between two within-subject experimental conditions found in an original micro-PK dataset (n = 12,254) using a QRNG. However, after data collection and analyses, a data error was detected in the original to-be-replicated dataset. A reanalysis of the original correlation effect after error correction revealed strong evidence for the absence of a correlation in the original data. This study's primary goal was to test the existence of a correlational micro-PK effect in the present data as specified in the pre-registration. In addition to this replication attempt, the present study also can be considered an unsystematic case report or field study on experimenter psi (e-psi), since a strong expectation was formed initially about the occurrence of an effect that indeed was objectively absent from the original data. This study's results indicate no evidence for the existence of a correlational (and standard) micro-PK effect. In other words, the actual correlational data did not meet the experimenters' conscious expectations, and thus no consciously based effect of e-psi on micro-PK was found. However, the change in evidence for the effect across time described by the sequential Bayes factor resembled a data pattern that also was frequently reported by the experimenters in past studies. Although these data did not meet the criterion of statistical significance and a rejection of the null hypothesis failed, the marginal effects might be interpreted as weak influences based on unconscious e-psi. In addition, the trend observed matches both experimenters' general beliefs about the occurrence of e-psi in micro-PK. These findings' implications for the application of scientific methods to the study of micro-PK and psi in general are discussed

Quantum Measurement as Pragmatic Information Transfer: Observer Effects on (S)objective Reality Formation

Objective: In this study, quantum measurement is conceptualized as pragmatic information transfer when an intentional observer perceives motive-relevant quantum-based outcomes. Owing to the nature of pragmatic information as described in Lucadou’s Model of Pragmatic Information, this information transfer causes an observer-dependent intentional co-formation of reality and can only be scientifically documented under reduced objectivity conditions. The effects thus reflect a “sobjective” reality that occupies the space between subjectivity and objectivity. The present study was designed to find evidence for the existence of this sobjective reality. Method: A pre-registered micro-psychokinesis task involving a quantum random number generator assessed the impact of intentional observation on quantum-based stochastic outcomes under experimental variations of the applied measures’ objectivity. Results: As predicted, an intentionally congruent bias in quantum-based outcomes was observed using subjective memory data from the observations when additional objective computer-stored data were not inspected and finally erased (i.e., objectivity was reduced). Quantum randomness was confirmed in a maximum objective data collection context for both stored and memory data. Conclusion: The results indicate that pragmatic information was transferred during trial observation when scientific objectivity was reduced. The evidence for intentionally based reality formation or quantum-based random reality emergence was shown to be a function of the measurements’ objectivity levels. The data suggest the existence of a sobjective reality and that a physicalist/materialist or an intentional creation worldview depends on the presence of an intentional agent and the definition of the measurement process

Outcome in patients perceived as receiving excessive care across different ethical climates: a prospective study in 68 intensive care units in Europe and the USA

Purpose: Whether the quality of the ethical climate in the intensive care unit (ICU) improves the identification of patients receiving excessive care and affects patient outcomes is unknown. Methods: In this prospective observational study, perceptions of excessive care (PECs) by clinicians working in 68 ICUs in Europe and the USA were collected daily during a 28-day period. The quality of the ethical climate in the ICUs was assessed via a validated questionnaire. We compared the combined endpoint (death, not at home or poor quality of life at 1 year) of patients with PECs and the time from PECs until written treatment-limitation decisions (TLDs) and death across the four climates defined via cluster analysis. Results: Of the 4747 eligible clinicians, 2992 (63%) evaluated the ethical climate in their ICU. Of the 321 and 623 patients not admitted for monitoring only in ICUs with a good (n = 12, 18%) and poor (n = 24, 35%) climate, 36 (11%) and 74 (12%), respectively were identified with PECs by at least two clinicians. Of the 35 and 71 identified patients with an available combined endpoint, 100% (95% CI 90.0–1.00) and 85.9% (75.4–92.0) (P = 0.02) attained that endpoint. The risk of death (HR 1.88, 95% CI 1.20–2.92) or receiving a written TLD (HR 2.32, CI 1.11–4.85) in patients with PECs by at least two clinicians was higher in ICUs with a good climate than in those with a poor one. The differences between ICUs with an average climate, with (n = 12, 18%) or without (n = 20, 29%) nursing involvement at the end of life, and ICUs with a poor climate were less obvious but still in favour of the former. Conclusion: Enhancing the quality of the ethical climate in the ICU may improve both the identification of patients receiving excessive care and the decision-making process at the end of life

Intentional Observer Effects on Quantum Randomness: A Bayesian Analysis Reveals Evidence Against Micro-Psychokinesis

Intentional effects of human observation on the output of quantum-based random number generators (tRNG) have been studied for decades now. This research has been known as micro-psychokinesis (micro-PK) and many studies in the field reported evidence for mentally induced non-random deviations from chance. A most recent meta-analysis from Bösch et al. (2006) revealed a very small and heterogeneous overall effect size that indicated a significant deviation from chance across studies. There remains doubt among the scientific community on the existence of micro-PK given: (i) the small and heterogenous effect; and (ii) the fact that several independent replication attempts of prominent studies failed to confirm the original results. The study presented here was intended to provide decisive evidence for or against the existence of micro-PK. An online experiment with 12,571 participants was conducted. The Bayesian analysis revealed strong evidence for H0 (BF01 = 10.07). Thus, micro-PK did not exist in the data. A closer inspection of the temporal change of the effect seemed to suggest a non-random oscillative structure with a higher frequency than observed in simulated data. The possible role of entropy and the relation to the model of pragmatic information from von Lucadou (2015) is discussed

Atomic scale imaging of the negative charge induced by a single vanadium dopant atom in monolayer WSe2_2 using 4D-STEM

There has been extensive activity exploring the doping of semiconducting two-dimensional (2D) transition metal dichalcogenides in order to tune their electronic and magnetic properties. The outcome of doping depends on various factors, including the intrinsic properties of the host material, the nature of the dopants used, their spatial distribution as well as their interactions with other types of defects. A thorough atomic-level analysis is essential to fully understand these mechanisms. In this work, vanadium doped WSe$_2$ monolayer grown by molecular beam epitaxy is investigated using four-dimensional scanning transmission electron microscopy (4D-STEM). Through center of mass-based reconstruction, atomic scale maps are produced, allowing the visualization of both the electric field and the electrostatic potential around individual V atoms. To provide quantitative insights, these results are successfully compared with multislice image simulations based on ab initio calculations, accounting for lens aberrations. Finally, a negative charge around the V dopants is detected as a drop in the electrostatic potential, unambiguously demonstrating that 4D-STEM can be used to detect and to accurately analyze single dopant charge states in semiconducting 2D materials.Comment: 17 pages, 4 figures and Supporting Informatio

Study protocol of the multi-site randomised controlled REDALI-DEM trial - The effects of structured Relearning methods on Daily Living task performance of persons with Dementia

<p>Abstract</p> <p>Background</p> <p>Evidence from pilot trials suggests that structured learning techniques may have positive effects on the performance of cognitive tasks, movement sequences or skills in patients with Alzheimer's disease. The purpose of this trial is to evaluate whether the usual method of learning by trial and error or the method of errorless learning demonstrate better effects on the performance of two selected daily living tasks six weeks after the intervention in people with mild to moderate dementia.</p> <p>Methods/Design</p> <p>A seven-centre single-blind, active-controlled design with a 1:1 randomisation for two parallel groups will include 175 persons diagnosed with Alzheimer's disease or mixed type dementia (MMSE 14-24), living at home, showing at least moderate need for assistance in instrumental activities of daily living; primary carer available and informed consent of patient and primary carer. Patients of both study arms will receive 15 one-hour-sessions at home by trained interventionists practising two daily living tasks individually selected. In one group the trial and error technique and in the other group the errorless learning method will be applied. Primary outcome is the task performance measured with the Task Performance Scale six weeks post treatment.</p> <p>Discussion</p> <p>The trial results will inform us to improve guidelines for instructing individuals with memory impairments. A user-friendly practice guideline will allow an efficient implementation of structured relearning techniques for a wide range of service providers in dementia care.</p> <p>Trial registration</p> <p>DRKS00003117</p

Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: The Seniors Health and Activity Research Program Pilot (SHARP-P) Study, a randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>The efficacy of non-pharmacological intervention approaches such as physical activity, strength, and cognitive training for improving brain health has not been established. Before definitive trials are mounted, important design questions on participation/adherence, training and interventions effects must be answered to more fully inform a full-scale trial.</p> <p>Methods</p> <p>SHARP-P was a single-blinded randomized controlled pilot trial of a 4-month physical activity training intervention (PA) and/or cognitive training intervention (CT) in a 2 × 2 factorial design with a health education control condition in 73 community-dwelling persons, aged 70-85 years, who were at risk for cognitive decline but did not have mild cognitive impairment.</p> <p>Results</p> <p>Intervention attendance rates were higher in the CT and PACT groups: CT: 96%, PA: 76%, PACT: 90% (p=0.004), the interventions produced marked changes in cognitive and physical performance measures (p≤0.05), and retention rates exceeded 90%. There were no statistically significant differences in 4-month changes in composite scores of cognitive, executive, and episodic memory function among arms. Four-month improvements in the composite measure increased with age among participants assigned to physical activity training but decreased with age for other participants (intervention*age interaction p = 0.01). Depending on the choice of outcome, two-armed full-scale trials may require fewer than 1,000 participants (continuous outcome) or 2,000 participants (categorical outcome).</p> <p>Conclusions</p> <p>Good levels of participation, adherence, and retention appear to be achievable for participants through age 85 years. Care should be taken to ensure that an attention control condition does not attenuate intervention effects. Depending on the choice of outcome measures, the necessary sample sizes to conduct four-year trials appear to be feasible.</p> <p>Trial Registration</p> <p>Clinicaltrials.gov Identifier: <a href="http://www.clinicaltrials.gov/ct2/show/NCT00688155">NCT00688155</a></p