Design, synthesis and anticonvulsant activity of some new 5,7-dibromoisatin semicarbazone derivatives

A series of 5,7-dibromoisatin semicarbazones have been synthesized in good yield, involving aryl urea and aryl semicarbazide formation. The structures of the synthesized compounds were confirmed on the basis of their spectral data. All the compounds were evaluated for anticonvulsant and CNS depressant activities. Anticonvulsant activity was determined after intraperitoneal (i.p.) administration to mice by maximal electroshock (MES) induced seizure method and minimal motor impairment was determined by rotarod test. A computational study was carried out for prediction of pharmacokinetic properties and making them potentially promising agents for the treatment of epilepsy. Compounds (Z)-1-(5,7-dibromo-2-oxoindolin-3-ylidene)-4-(4-chlorophenyl)semicarbazide (DH-05), (Z)-1-(5,7-dibromo-2-oxoindolin-3-ylidene)-4-(3-chloro-4-fluorophenyl)semicarbazide (DH-11) and (Z)-1-(5,7-dibromo-1-methyl-2-oxoindolin-3-ylidene)-4-(3-chloro-4-fluorophenyl)semicarbazide (DH-12) exhibited prominent anticonvulsant effect in the series with little or no neurotoxicity and little CNS depressant effect as compared to standard drug

BURROW ARCHITECTURE OF RED GHOST CRAB OCYPODE MACROCERA (H. MILNE-EDWARDS, 1852) : A CASE STUDY IN INDIAN SUNDARBANS

A study on burrow architecture and burrow morphology of the red ghost crab (Ocypode macrocera) was carried out at the southern proximity of the Sagar island (21°37.973' N, to E 88° 04.195'), western sector of Indian Sundarbans that faces the regular tidal influences of Bay of Bengal. Ocypode macrocera constructs burrows that are highly species specific and used by single individual. Four types of burrow patterns were observed like ‘I’, ‘J’ ‘U’ and ‘semi-U’ type with different sizes as revealed by POP casting. Important physic-chemical parameters like air temperature, temperature and salinity of the water were significantly varied (P < 0.05) throughout seasons in the Ocypode zone. Burrow sand column temperature were also significantly varied from ambient air temperature thus exhibiting preference for cooler subterranean residential compartment. The digging behaviour of Ocypodes enhances oxygenation in the ground soil and facilitates decomposition of organic materials, nutrient recycling, entrapping the sediments and mangrove seedlings and helps the process of bioturbation. As per the preliminary observations it was suggested that burrow shape is directly related to tidal action and metabolic activities of the crab are strongly correlated with burrow microenvironment. They are adapted to the different sediment conditions, tidal fluctuations, varying salinity gradients, air and water temperatures and other environmental fluctuations

Effects of ultraviolet radiation on pigmentation and malondialdehyde content of three aquatic macrophytes

A study has been done in order to evaluate the ill effects of UV-A,UV-B and UV-C on pigmentation and malondialdehyde content of floating macrophytes (Lemna sp., Pistia sp. and Eichhornia sp.) in one, three, and five days interval. Study results revealed that all types of ultraviolet light (UV-A, UV-B, and UV-C) did not produce same extent of ill effects on the studied macrophytes. Pistia sp. and Eichhornia sp. showed similar reduction pattern of chl a/chl b ratio with respect to control. Results also suggest that among the three types of radiation only UV-B showed higher level of changes in both the pigment and malondialdehyde content. Moreover, among the three tested macrophytes only Lemna sp. showed some protective role against UV radiation compared to other to macrophytes

Bibliometric Study of Authorship Pattern Literature

The main objective of this study is to conduct a bibliometric analysis of scholarly publications of Authorship Pattern. The present study covers 1723 research papers published in the area of authorship pattern and indexed in Scopus database from the year 2013 to 2022. These research publications considered for the present study have been analysed based on their year wise growth, pattern of authorship, times citations, type of publication, most productive publication source as well as countries and institutions. The study shows the positive growth of the literatures with collaborative authorship pattern and good citation status. This original research paper will be helpful to the researchers of library and information science, especially who are working in the area of bibliometrics studies.Comment: 7 pages, 7 table

Laboratory and Field Performance of Buried Steel-Reinforced High Density Polyethylene (SRHDPE) Pipes in a Ditch Condition under a Shallow Cover

Metal and plastic pipes have been used extensively as storm sewers and buried drainage structures in transportation projects. Metal pipes have high strength and stiffness but are susceptible to corrosion from wastewaters containing acid, and from aggressive soils. Plastic pipes are resistant to corrosion, erosion, and biological attack but have certain disadvantages including lower long-term strength and stiffness (dimensional reliability), buckling, and tearing of pipe wall. To address the disadvantages of metal and plastic pipes, a new product, steel-reinforced high-density polyethylene (SRHDPE) pipe, has been developed and introduced to the market, which has high-strength steel reinforcing ribs wound helically and covered by corrosion-resistant high density polyethylene (HDPE) resin inside and outside. The steel reinforcement adds ring stiffness to the pipe to maintain the cross-section shape during installation and to support overburden stresses and traffic loading. The HDPE resin protects the steel against corrosion and provides a smooth inner wall. The combination of steel and plastic materials results in a strong and durable material with a smooth inner wall. Different methods are available for the design of metal and plastic pipes. The American Water Works Association (AWWA) Manual M11 (2004) provided the design procedure for metal pipes and the 2007 ASSHTO LRFD Bridge Design Specifications had separate design procedures for metal and plastic pipes. However, it is not clear whether any of these procedures for metal and plastic pipes can be used to design an SRHDPE pipe. Moreover, no approved installation or design specification is available SPECIFICALLY for the SRHDPE pipes. Some research has been conducted on SRHDPE pipes to understand the performance of SRHDPE pipes in the laboratory including the laboratory tests conducted by Khatri (2012). To investigate the performance of the pipe with various backfills, in addition to the laboratory tests conducted by Khatri (2012) with the sand backfill, a laboratory test with the crushed stone backfill was conducted in a ditch condition under 2 feet of shallow cover. This was performed in a large geotechnical testing box 10 feet long x 6.6 feet wide x 6.6 feet high. Based on the laboratory testing and analysis on the SRHDPE pipes, it can be concluded that (1) the pipe wall-soil interface should be designed as a fully bonded interface to be conservative, (2) the Giroud and Han (2004) method and the simplified distribution method in the 2007 AASHTO LRFD Bridge Design Specifications reasonably predicted the pressures on the top of the SRHDPE pipes induced by static and cyclic loadings, (3) the modified Iowa formula (1958) under predicted the deflections of the SRHDPE pipes during the installation and over-predicted the deflections during static and cyclic loadings, (4) the formula provided by Masada (2000) can be comfortably used to determine the ratio of the vertical to horizontal deflection of the SRHDPE pipe, (5) the pipe wall area was enough to resist the wall thrust during installation and loadings, and (6) the highest measured strains recorded in steel and plastic during the installation and loadings in all the tests were within the permissible values. The laboratory tests however have some limitations. For example, the installation procedure of the pipe in the test box may be different from the field installation due to the limited space and construction equipment in the laboratory. The laboratory box tests may have a boundary effect. Therefore, a field test was conducted to verify the lab test results The results obtained in the field test were found in agreement with the results obtained for the laboratory test during the installation and the traffic loading

Bibliometric Study of Indian Open Access Social Science Literature

The purpose of this study is to trace out the growth and development of social science literature in open access environment published from India. Total 1195 open access papers published and indexed in Scopus database in ten years have considered for the present study. Research publication from 2008 to 2017 have been analyzed based on literature growth, authorship pattern, activity index, prolific authors and institutions, publication type, channel and citation count have examined to provide a clear picture of Indian social science research. The study shows the dominance of shared authorship and sixty percentages of total articles have been cited. This original research paper described the research productivity of social science in open access context and will be helpful to the social scientist and library professional as a whole