Impact of AI & AR on Consumer Perceptions of Various Firms: An Analysis

The influence that Augmented Reality (AR) & Artificial Intelligence (AI) has had on the retail industry is the subject of this research. More specifically, the research focuses on how AR & AI has improved the shopping experience by including aspects of excitement and mystery. Augmented reality (AR) is a technology that enhances a user's experience of the real world by superimposing digital content on top of it. This results in interactions between customers and shops with the help of AI that are more customised and engaging. Enhanced shopping experiences for customers are being achieved by retailers through the implementation of augmented reality (AR) & AI through the utilisation of smart devices and developments in internet technology. This is accomplished through the use of features such as virtual fitting rooms and presentations of products in real time. In spite of the positive promises, there are additional problems that need to be handled. These challenges include high costs associated with technology, limited numbers of devices being used, and issues around privacy. A comprehensive literature review investigates a number of studies, such as Mussa's (2022) investigation into the connection between augmented reality (AR), consumer experience, and purchase intention during the post pandemic era, and Xue, Parker, and Hart's (2022) investigation into the application of AR & AI in the retail industry's consumer experience design. The themes that are being discussed include current developments in technology, real-world examples, and upcoming trends such as the incorporation of social media and the customisation of shopping experiences. Augmented reality (AR) & Artificial Intelligence (AI) has the potential to boost customer confidence and raise the likelihood that they will make a purchase. The successful completion of integration is contingent upon overcoming technical obstacles and achieving commercial acceptability

Role of Jagged1 in the Enrichment of Cancer Stem Cells in HER2+ Breast Cancer

Purpose: Breast cancer is the second leading cause of cancer-related deaths among women worldwide. Human Epidermal Growth Factor Receptor 2 (HER2) positive subtype of breast cancer is driven by a subpopulation of cells possessing stem cell properties of self-renewal and differentiation, known as Cancer Stem Cells (CSCs). CSCs are implicated in tumor growth as well as radiotherapy and chemotherapy associated resistance. Notch receptors promote breast CSCs survival and self-renewal, and overexpression of Notch ligand Jagged1 predicts poor prognosis. We showed previously that Notch could be an important target in trastuzumab/lapatinib resistant HER2+ breast cancer. Experimental Design: Here, we sought to determine whether anti-HER2 therapy selects for Jagged-1/Notch-dependent CSCs that are responsible for tumor recurrence. Results: The current study describes a novel role of surface expression of Jagged1 in the enrichment of CSCs. HER2 inhibition selects out a subpopulation of cells that i. express higher Jagged1 on the membrane, ii. interact with Notch-1 and Notch-3 and have higher Notch activation, iii. are enriched for CSCs and iv. predict poor overall cumulative survival in women with HER2+ breast cancer. Conclusions: The results demonstrate that HER2 blockade in breast cancer cells enriches a Jagged1 high subpopulation that has higher CSC potential and is resistant to HER2 inhibitors. The implications of this work are that dual blockade of Jagged-1 and HER2 could be more effective than either therapy alone to eliminate both HER2 and Jagged-1 dependent cancer cells

Factors Affecting Customer's Viewpoint of AI Enabled Services in India's Banking Sector

The banking industry has undergone a significant transformation as a consequence of the increasing emphasis that has been placed on meeting the expectations of clients. Customers who have a solid grasp of technology and who routinely interact with cutting-edge developments assume that banks will provide experiences that are straightforward and easy. In order to facilitate activities such as the use of “digital currency, electronic banking, and the transfer of physical cash”, financial institutions have extended their scope of operations to include the retail, information technology & telecommunications industries. Users have profited from the ease of being able to access banking services around the clock as a consequence of these developments; nonetheless, the financial system has also been badly impacted as a result of these innovations. In addition to this, the research explores the positive & negative factors that are related with the use of artificial intelligence technology in the banking sector of India. The purpose of this research is to provide a descriptive analysis of the implementation of “Artificial Intelligence (AI)” in the financial services sector and the influence that it has on interactions with clients. A total of 197 customers from public & private banks in Gujarat participated in the research project by filling out a questionnaire and providing their data. This was done in order to understand their perspectives & experiences

Design and Analysis of a Lift Assist Walker

Walkers provided stability to the elderly but cannot assist a person from sitting to standing. The objective of this project is to present the design and analysis of a lift assist walker. This report discusses the design and analysis of a collapsible lift assist walker capable of lifting a patient up to 250 lbs. from seated to standing in under 10 seconds. The designed walker utilized a two stage scissor mechanism with a gas spring assisted embedded linear actuator

Neoadjuvant chemotherapy and trastuzumab versus neoadjuvant chemotherapy followed by post-operative trastuzumab for patients with HER2-positive breast cancer

Neoadjuvant chemotherapy plus trastuzumab (NCT) increases the rate of pathological complete response (pCR) and event-free survival (EFS) compared to neoadjuvant chemotherapy (NC) alone in women with HER2 positive breast cancer (BC). pCR in this setting is associated with improved EFS. Whether NCT preferentially improves EFS in comparison to NC followed by adjuvant trastuzumab initiated postoperatively (NCAT) has not been addressed. Using clinical data from women with HER2 positive BC treated at 7 European institutions between 2007 and 2010 we sought to investigate the impact on breast cancer outcomes of concomitant (NCT) versus sequential (NCAT) treatment in HER2 positive early BC. The unadjusted hazard ratio (HR) for event free survival with NCT compared with NCAT was 0.63 (95% CI 0.37–1.08; p = 0.091). Multivariable analysis revealed that treatment group, tumour size and ER status were significantly associated with EFS from diagnosis. In the whole group NCT was associated with a reduced risk of an event relative to NCAT, an effect that was confined to ER negative (HR: 0.25; 95% CI, 0.10–0.62; p = 0.003) as opposed to ER positive tumours (HR: 1.07; 95% CI, 0.46–2.52; p = 0.869). HER2 positive/ER negative BC treated with NC gain greatest survival benefit when trastuzumab is administered in both the neoadjuvant and adjuvant period rather than in the adjuvant period alone. These data support the early introduction of targeted combination therapy in HER2 positive/ER negative BC

Investigation of Si(1-x)Ge(x) (x ≥ 0.85) Solar Cells for Affordable High Efficiency Solar Energy Conversion

Increasing global demand on energy mixed with climate change is demanding a cleaner, more robust energy source. Moreover, access to low cost energy sources in much of the developing world is essential to sustain human vitality and growth. Thus, solar photovoltaics has come to the forefront of the clean energy realm as one of the most promising energy generation devices. The novel semiconductor material known as Si0.05Ge0.95 has been proposed as an ideal bottom cell (infrared sensitive) as part of a multijunction stack that has the potential to exceed 45% energy conversion efficiency in a low cost format. However, these devices have not been studied experimentally; therefore the devices must be experimentally investigated and the cells’ dependence on material properties and processing must be determined and an optimized process flow must be developed. This has been done via various processing techniques and electrical characterization tools such as lighted current-voltage, quantum efficiency (QE), and energy-dispersive X-ray spectroscopy (EDX), as part of a Department of Energy supported effort. A working device has been produced using a Ni/Ge/Au front contact, which have made ohmic contact to the material without spiking through the junction. An internal quantum efficiency (IQE) measurement greater than 50% within the 1000 – 1600 nm wavelength range has also been measured on the cell. The information obtained thus far has created a pathway forward to substantially increase the IQE within the cell, making it amenable for future integration into a final multijunction solar cell architecture that has a practically achievable efficiency limit of 45%-50%.DoE - FPACEOSU - College of EngineeringNo embargoAcademic Major: Chemical Engineerin

Cytokine release syndrome and cancer immunotherapies - historical challenges and promising futures.

Cancer is the leading cause of death worldwide. Cancer immunotherapy involves reinvigorating the patient\u27s own immune system to fight against cancer. While novel approaches like Chimeric Antigen Receptor (CAR) T cells, bispecific T cell engagers, and immune checkpoint inhibitors have shown promising efficacy, Cytokine Release Syndrome (CRS) is a serious adverse effect and remains a major concern. CRS is a phenomenon of immune hyperactivation that results in excessive cytokine secretion, and if left unchecked, it may lead to multi-organ failure and death. Here we review the pathophysiology of CRS, its occurrence and management in the context of cancer immunotherapy, and the screening approaches that can be used to assess CRS and de-risk drug discovery earlier in the clinical setting with more predictive pre-clinical data. Furthermore, the review also sheds light on the potential immunotherapeutic approaches that can be used to overcome CRS associated with T cell activation