2,986 research outputs found
Partitioning random graphs into monochromatic components
Erd\H{o}s, Gy\'arf\'as, and Pyber (1991) conjectured that every -colored
complete graph can be partitioned into at most monochromatic components;
this is a strengthening of a conjecture of Lov\'asz (1975) in which the
components are only required to form a cover. An important partial result of
Haxell and Kohayakawa (1995) shows that a partition into monochromatic
components is possible for sufficiently large -colored complete graphs.
We start by extending Haxell and Kohayakawa's result to graphs with large
minimum degree, then we provide some partial analogs of their result for random
graphs. In particular, we show that if , then a.a.s. in every -coloring of there exists
a partition into two monochromatic components, and for if , then a.a.s. there exists an -coloring
of such that there does not exist a cover with a bounded number of
components. Finally, we consider a random graph version of a classic result of
Gy\'arf\'as (1977) about large monochromatic components in -colored complete
graphs. We show that if , then a.a.s. in every
-coloring of there exists a monochromatic component of order at
least .Comment: 27 pages, 2 figures. Appears in Electronic Journal of Combinatorics
Volume 24, Issue 1 (2017) Paper #P1.1
Large monochromatic components in expansive hypergraphs
A result of Gy\'arf\'as exactly determines the size of a largest
monochromatic component in an arbitrary -coloring of the complete
-uniform hypergraph when and . We prove a
result which says that if one replaces in Gy\'arf\'as' theorem by any
``expansive'' -uniform hypergraph on vertices (that is, a -uniform
hypergraph on vertices in which in which for all
disjoint sets with for all ), then one gets a largest monochromatic component of essentially the same
size (within a small error term depending on and ). As corollaries
we recover a number of known results about large monochromatic components in
random hypergraphs and random Steiner triple systems, often with drastically
improved bounds on the error terms.
Gy\'arf\'as' result is equivalent to the dual problem of determining the
smallest maximum degree of an arbitrary -partite -uniform hypergraph with
edges in which every set of edges has a common intersection. In this
language, our result says that if one replaces the condition that every set of
edges has a common intersection with the condition that for every
collection of disjoint sets with
for all there exists for all
such that , then the maximum degree of
is essentially the same (within a small error term depending on and
). We prove our results in this dual setting.Comment: 18 page
Spectroscopy, MOST Photometry, and Interferometry of MWC 314: Is it an LBV or an interacting binary?
MWC 314 is a bright candidate luminous blue variable that resides in a fairly
close binary system, with an orbital period of 60.7530.003 d. We observed
MWC 314 with a combination of optical spectroscopy, broad-band ground- and
space-based photometry, as well as with long baseline, near-infrared
interferometry. We have revised the single-lined spectroscopic orbit and
explored the photometric variability. The orbital light curve displays two
minima each orbit that can be partially explained in terms of the tidal
distortion of the primary that occurs around the time of periastron. The
emission lines in the system are often double-peaked and stationary in their
kinematics, indicative of a circumbinary disc. We find that the stellar wind or
circumbinary disc is partially resolved in the K\prime-band with the longest
baselines of the CHARA Array. From this analysis, we provide a simple,
qualitative model in an attempt to explain the observations. From the
assumption of Roche Lobe overflow and tidal synchronisation at periastron, we
estimate the component masses to be M1 M and M2
M, which indicates a mass of the LBV that is extremely low. In addition
to the orbital modulation, we discovered two pulsational modes with the MOST
satellite. These modes are easily supported by a low-mass hydrogen-poor star,
but cannot be easily supported by a star with the parameters of an LBV. The
combination of these results provides evidence that the primary star was likely
never a normal LBV, but rather is the product of binary interactions. As such,
this system presents opportunities for studying mass-transfer and binary
evolution with many observational techniques.Comment: 26 pages, 7 figures, 5 tables, 2 appendices with 7 additional tables
and 2 additional figures. Accepted for publication in MNRA
A lower bound on the multicolor size-Ramsey numbers of paths in hypergraphs
The r-color size-Ramsey number of a k-uniform hypergraph H, denoted by R^r(H), is the minimum number of edges in a k-uniform hypergraph G such that for every r-coloring of the edges of G there exists a monochromatic copy of H. In the case of 2-uniform paths Pn, it is known that Ω(r2n)=R^r(Pn)=O((r2logr)n) with the best bounds essentially due to Krivelevich. In a recent breakthrough result, Letzter, Pokrovskiy, and Yepremyan gave a linear upper bound on the r-color size-Ramsey number of the k-uniform tight path P(k)n; i.e. R^r(P(k)n)=Or,k(n). Winter gave the first non-trivial lower bounds on the 2-color size-Ramsey number of P(k)n for k≥3; i.e. R^2(P(3)n)≥8/3n−O(1) and R^2(P(k)n)≥⌈log2(k+1)⌉n−Ok(1) for k≥4.We consider the problem of giving a lower bound on the r-color size-Ramsey number of P(k)n (for fixed k and growing r). Our main result is that R^r(P(k)n)=Ωk(rkn) which generalizes the best known lower bound for graphs mentioned above. One of the key elements of our proof is a determination of the correct order of magnitude of the r-color size-Ramsey number of every sufficiently short tight path; i.e. R^r(P(k)k+m) = Θk(rm) for all 1≤m≤k.All of our results generalize to ℓ-overlapping k-uniform paths P(k,ℓ)n. In particular we note that when 1≤ℓ≤k/2, we have Ωk(r2n)=R^r(P(k,ℓ)n)=O((r2logr)n) which essentially matches the best known bounds for graphs mentioned above. Additionally, in the case k=3, ℓ=2, and r=2, we give a more precise estimate which implies R^2(P(3)n)≥28/9n−O(1), improving on the above-mentioned lower bound of Winter in the case k=3
A lower bound on the multicolor size-Ramsey numbers of paths in hypergraphs
The -color size-Ramsey number of a -uniform hypergraph , denoted by
, is the minimum number of edges in a -uniform hypergraph
such that for every -coloring of the edges of there exists a
monochromatic copy of . In the case of -uniform paths , it is known
that with the best bounds
essentially due to Krivelevich. In a recent breakthrough result, Letzter,
Pokrovskiy, and Yepremyan gave a linear upper bound on the -color
size-Ramsey number of the -uniform tight path ; i.e.
. Winter gave the first non-trivial lower
bounds on the 2-color size-Ramsey number of for ; i.e.
and for .
We consider the problem of giving a lower bound on the -color size-Ramsey
number of (for fixed and growing ). Our main result is
that which generalizes the best known
lower bound for graphs mentioned above. One of the key elements of our proof is
a determination of the correct order of magnitude of the -color size-Ramsey
number of every sufficiently short tight path; i.e.
for all .
All of our results generalize to -overlapping -uniform paths
. In particular we note that when , we have which essentially matches the best known bounds for graphs mentioned
above. Additionally, in the case , , and , we give a more
precise estimate which implies ,
improving on the above-mentioned lower bound of Winter in the case .Comment: 18 pages, updated based on referee comment
On the multicolor Ramsey numbers of balanced double stars
The balanced double star on vertices, denoted , is the tree
obtained by joining the centers of two disjoint stars each having leaves.
Let be the smallest integer such that in every -coloring of the
edges of there is a monochromatic copy of , and let
be the smallest integer such that in every
-coloring of the edges of there is a monochromatic copy of . It
is known that and
\cite{HJ}, but very little is known about and
when (other than the bounds which
follow from considerations on the number of edges in the majority color class).
In this paper we prove the following for all (where the lower
bounds are adapted from existing examples): and
These bounds are similar to the best
known bounds on and , where
is a path on vertices (which is also a balanced tree). We
also give an example which improves the lower bound on
when and
Consensus-based care recommendations for adults with myotonic dystrophy type 1
Purpose of review
Myotonic dystrophy type 1 (DM1) is a severe, progressive genetic disease that affects between 1 in 3,000 and 8,000 individuals globally. No evidence-based guideline exists to inform the care of these patients, and most do not have access to multidisciplinary care centers staffed by experienced professionals, creating a clinical care deficit.
Recent findings
The Myotonic Dystrophy Foundation (MDF) recruited 66 international clinicians experienced in DM1 patient care to develop consensus-based care recommendations. MDF created a 2-step methodology for the project using elements of the Single Text Procedure and the Nominal Group Technique. The process generated a 4-page Quick Reference Guide and a comprehensive, 55-page document that provides clinical
care recommendations for 19 discrete body systems and/or care considerations.
Summary
The resulting recommendations are intended to help standardize and elevate care for this patient population and reduce variability in clinical trial and study environments. Described as “one of the more variable diseases found in medicine,” myotonic dystrophy type
1 (DM1) is an autosomal dominant, triplet-repeat expansion disorder that affects somewhere between 1:3,000 and 1:8,000 individuals worldwide.1 There is a modest association between increased repeat expansion and disease severity, as evidenced by the average age of onset and overall morbidity of the condition. An expansion of over 35 repeats typically indicates an unstable and expanding mutation. An expansion of 50 repeats or higher is consistent with a diagnosis of DM1. DM1 is a multisystem and heterogeneous disease characterized by distal weakness, atrophy, and myotonia, as well as symptoms in the heart, brain, gastrointestinal tract, endocrine, and respiratory systems. Symptoms may occur at any age. The severity of the condition varies widely among affected individuals, even among members of the same family.
Comprehensive evidence-based guidelines do not currently
exist to guide the treatment of DM1 patients. As a result, the international patient community reports varied levels of care and care quality, and difficulty accessing care adequate to manage their symptoms, unless they have access to multidisciplinary neuromuscular clinics.
Consensus-based care recommendations can help standardize
and improve the quality of care received by DM1 patients
and assist clinicians who may not be familiar with the significant variability, range of symptoms, and severity of the disease. Care recommendations can also improve the landscape for clinical trial success by eliminating some of the inconsistencies in patient care to allow more accurate understanding of the benefit of potential therapies
Measurements of the pp → ZZ production cross section and the Z → 4ℓ branching fraction, and constraints on anomalous triple gauge couplings at √s = 13 TeV
Four-lepton production in proton-proton collisions, pp -> (Z/gamma*)(Z/gamma*) -> 4l, where l = e or mu, is studied at a center-of-mass energy of 13 TeV with the CMS detector at the LHC. The data sample corresponds to an integrated luminosity of 35.9 fb(-1). The ZZ production cross section, sigma(pp -> ZZ) = 17.2 +/- 0.5 (stat) +/- 0.7 (syst) +/- 0.4 (theo) +/- 0.4 (lumi) pb, measured using events with two opposite-sign, same-flavor lepton pairs produced in the mass region 60 4l) = 4.83(-0.22)(+0.23) (stat)(-0.29)(+0.32) (syst) +/- 0.08 (theo) +/- 0.12(lumi) x 10(-6) for events with a four-lepton invariant mass in the range 80 4GeV for all opposite-sign, same-flavor lepton pairs. The results agree with standard model predictions. The invariant mass distribution of the four-lepton system is used to set limits on anomalous ZZZ and ZZ. couplings at 95% confidence level: -0.0012 < f(4)(Z) < 0.0010, -0.0010 < f(5)(Z) < 0.0013, -0.0012 < f(4)(gamma) < 0.0013, -0.0012 < f(5)(gamma) < 0.0013
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