Fuzzy-Based Histogram Partitioning for Bi-Histogram Equalisation of Low Contrast Images

The conventional histogram equalisation (CHE), though being simple and widely used technique for contrast enhancement, but fails to preserve the mean brightness and natural appearance of images. Most of the improved histogram equalisation (HE) methods give better performance in terms of one or two metrics and sacri ce their performance in terms of other metrics. In this paper, a novel fuzzy based bi-HE method is proposed which equalises low contrast images optimally in terms of all considered metrics. The novelty of the proposed method lies in selection of fuzzy threshold value using level-snip technique which is then used to partition the histogram into segments. The segmented sub-histograms, like other bi-HE methods, are equalised independently and are combined together. Simulation results show that for widerange of test images, the proposed method improves the contrast while preserving other characteristics and provides good trade-off among all the considered performance metrics.This work was supported by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, under Grant DF-374-135-1441

Logic Locking - Connecting Theory and Practice

Due to the complexity and the cost of producing integrated circuits, most hardware circuit designers outsource the manufacturing of their circuits to a third-party foundry. However, a dishonest foundry may abuse its access to the circuit\u27s design in a variety of ways that undermine the designer\u27s investment or potentially introduce vulnerabilities. To combat these issues, the hardware community has developed the notion of logic locking, which allows the designer to send the foundry a ``locked\u27\u27 version of the original circuit. After the locked circuit has been manufactured, authorized users can unlock the original functionality with a secret key. Unfortunately, most logic locking schemes are analyzed using informal security notions, leading to a cycle of attacks and ad hoc defenses that impedes the adoption of logic locking. In this work, we propose a formal simulation-based security definition for logic locking. We then show that a construction based on universal circuits provably satisfies the definition. More importantly, we explore ways to efficiently realize our construction in actual hardware. This entails the design of alternate approaches and optimizations, and our evaluation (based on standard hardware metrics like power, area, and performance) illuminates tradeoffs between these designs

Ultralight vector dark matter search using data from the KAGRA O3GK run

Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Hybrid RFSVM: Hybridization of SVM and Random Forest Models for Detection of Fake News

The creation and spreading of fake information can be carried out very easily through the internet community. This pervasive escalation of fake news and rumors has an extremely adverse effect on the nation and society. Detecting fake news on the social web is an emerging topic in research today. In this research, the authors review various characteristics of fake news and identify research gaps. In this research, the fake news dataset is modeled and tokenized by applying term frequency and inverse document frequency (TFIDF). Several machine-learning classification approaches are used to compute evaluation metrics. The authors proposed hybridizing SVMs and RF classification algorithms for improved accuracy, precision, recall, and F1-score. The authors also show the comparative analysis of different types of news categories using various machine-learning models and compare the performance of the hybrid RFSVM. Comparative studies of hybrid RFSVM with different algorithms such as Random Forest (RF), na&iuml;ve Bayes (NB), SVMs, and XGBoost have shown better results of around 8% to 16% in terms of accuracy, precision, recall, and F1-score