Traditional healing and antimicrobial role of the herbal drug against UTIs by ethnic people of Darjeeling tea gardens, India

The herbal age-old traditional method is practiced even today to treat Urinary Tract Infection (UTI) by the ethnic inhabitants of tea gardens of Darjeeling Himalaya, India. The aim of this study was to explore and document the traditional ways of healing UTIs. The information was collected from selected tea gardens and data was quantitatively analyzed with the help of ethnobotanical indices viz., use value, plant part value, family use value, fidelity level (%), and informant consensus factor. Antibiogram of four UTI-causing bacteria (Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris and Staphylococcus aureus) was also established by Kirbye Bauer’s disc diffusion method. Antibacterial activity of twelve mostly used plants like Cheliocostus speciosus, Equisetum diffusum, Saccharum officinarum, Elettaria cardamomum, Coriandrum sativum, Plantago asiatica ssp. erosa, Centella asiatica, Achyranthes bidentata, Carex cruciata, Drymaria cordata ssp. diandra, Nephrolepis cordifolia, Malvaviscus arboreus were assessed against the aforementioned bacterial strains. Drymaria cordata and Centella asiatica on comparative MIC and MBC study showed the lowest MIC and MBC value of 0.29 mg/mL each against Staphylococcus, representing their effectivity. Nephrolepis cordifolia with 100% FL showed the lowest MIC and MBC value 0.67 mg/mL each against E. coli K12. The uses of these plants known from the ethnomedicinal knowledge of the healers could be promoted as complementary medicine to treat UTI.

mRNA Coronavirus Disease 2019 Vaccine-Associated Myopericarditis in Adolescents: A Survey Study

In this survey study of institutions across the US, marked variability in evaluation, treatment, and follow-up of adolescents 12 through 18 years of age with mRNA coronavirus disease 2019 (COVID-19) vaccine-associated myopericarditis was noted. Only one adolescent with life-threatening complications was reported, with no deaths at any of the participating institutions

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Ethnomedicinal approach against bone fracture among the tea garden workers of Darjeeling Hills

512-517Treatment against bone fracture is a common practice among the tea garden workers who are mainly ethnic communities of Darjeeling hills. Surveys were conducted during 2015–2017 in Dhajea, Avongrove and Mim tea gardens and six formulations have been recorded and collated. A total of 12 species of plants along with additive materials have been recorded for curing bone fracture related ailments. Detailed account of plant parts used, modes of preparations of dose and efficacy rate have been enumerated in this article