246 research outputs found
Antarctic network of lamp-calibrated multichannel radiometers for continuous ozone and uv radiation data
International audienceThree NILU-UV multichannel radiometers have been installed in 1999 at the Argentinian sites of Ushuaia (54S), Marambio (64S) and Belgrano-II (77S) in order to continuously monitor UV radiation, photosynthetically active radiation and total ozone. The measurements were established by INM, Spain in collaboration with FMI, Finland, DNA-IAA, Argentina and CADIC, Argentina to observe and characterize the spatial and temporal evolution of ozone and ultraviolet radiation in the Antarctic region. Special attention has been given to the quality control and quality assurance of the measurements under harsh climatological conditions. The ozone and UV time series of 2000?2006 were calibrated using a polynomial fit for lamp measurements performed every second week all year round. The gaps in these data are minimal, with almost no data missing, and the data products are available from http://www.polarvortex.org in near real time. The data products include the erythemally-weighted UV, UVB and UVA radiation, photosynthetically active radiation (PAR), total ozone (O3) and a cloud parameter (CLT). For UV data, dose rates as well as daily doses are available; from these the maximum measured UV indices (UVI), during 2000?2006, were 12.0, 9.7 and 8.1 at Ushuaia, Marambio and Belgrano-II, respectively
UV measurements at Marambio and Ushuaia during 2000–2010
Solar ultraviolet (UV) irradiances were measured with NILU-UV
multichannel radiometers at Ushuaia (54° S) and Marambio
(64° S) between 2000 and 2013. The measurements were part of the
Antarctic NILU-UV network, which was started in cooperation between Spain,
Argentina and Finland. The erythemally weighted UV irradiance time series of
both stations were analysed for the
first time. The quality assurance procedures included a travelling reference
instrument to transfer the irradiance scale to the stations. The time series
were homogenized and high quality measurements were available for the period
2000–2010. During this period UV indices of 11 or more were measured on 5
and 35 days at Marambio and Ushuaia, respectively. At Marambio, the peak
daily maximum UV index of 12 and daily doses of around
7 kJ m−2 were measured in November
2007. The highest UV daily doses at both stations were typically around
6 kJ m−2 and occurred when the stations were inside the polar vortex,
resulting in very low total ozone amount. At both stations, daily doses in
late November could even exceed those in the summer. At Marambio, in some
years, also daily doses in October can be as high as those during the summer.
At Ushuaia, the peak daily maximum UV index of 13 was measured twice: in
November 2003 and 2009. Also during those days, the station of Ushuaia was
inside the polar vortex.</p
Effect of the Monocyte Chemoattractant Protein-1/CC Chemokine Receptor 2 System on Nephrin Expression in Streptozotocin-Treated Mice and Human Cultured Podocytes
OBJECTIVE-Monocyte chemoattractant protein-1 (MCP-1), a chemokine binding to the CC chemokine receptor 2 (CCR2) and promoting monocyte infiltration, has been implicated in the pathogenesis of diabetic nephropathy. To assess the potential relevance of the MCP-1/CCR2 system in the pathogenesis of diabetic proteinuria, we studied in vitro if MCP-1 binding to the CCR2 receptor modulates nephrin expression in cultured podocytes. Moreover, we investigated in vivo if glomerular CCR2 expression is altered in kidney biopsies from patients with diabetic nephropathy and whether lack of MCP-1 affects proteinuria and expression of nephrin in experimental diabetes.
RESEARCH DESIGN AND METHODS-Expression of nephrin was assessed in human podocytes exposed to rh-MCP-1 by immunofluorescence and real-time PCR. Glomerular CCR2 expression was studied in 10 kidney sections from patients with overt nephropathy and eight control subjects by immunohistochemistry. Both wild-type and MCP-1 knockout mice were made diabetic with streptozotocin. Ten weeks after the onset of diabetes, albuminuria and expression of nephrin, synaptopodin, and zonula occludens-1 were examined by immunofluorescence and immunoblotting.
RESULTS-In human podocytes, MCP-1 binding to the CCR2 receptor induced a significant reduction in nephrin both mRNA and protein expression via a Rho-dependent mechanism. The MCP-1 receptor, CCR2, was overexpressed in the glomerular podocytes of patients with overt nephropathy. In experimental diabetes, MCP-1 was overexpressed within the glomeruli and the absence of MCP-1 reduced both albuminuria and downregulation of nephrin and synaptopodin.
CONCLUSIONS-These findings suggest that the MCP-1/CCR2 system may be relevant in the pathogenesis of proteinuria in diabetes
Symposium-in-Print: UV Effects on Aquatic and Coastal Ecosystems
tropical to sub-Antarctic regions in South America. Ground
UV irradiances were measured by multichannel radiometers
as part of the Inter American Institute for Global Change
Radiation network. The irradiance channels used for this study
were centered at 305 nm (for UV-B measurements) and 340 nm
(for UV-A measurements). Results were presented as daily
maximum irradiances, as monthly averaged, daily integrated
irradiances and as the ratio of 305 nm to 340 nm. These findings
are the first to be based on a long time series of semispectral
data from the southern region of South America. As expected,
the UV-B channel and total column ozone varied with latitude.
The pattern of the UV-A channel was more complex because of
local atmospheric conditions. Total column ozone levels of ~ 2 2 0
Dobson Units were observed at all sites. Analysis of autocorrelations
showed a larger persistence of total column ozone level
than irradiance. A decreasing cross-correlation coefficient
between 305 and 340 nm and an increasing cross-correlation
coefficient between 305 nm and ozone were observed at higher
latitudes, indicating that factors such as cloud cover tend to
dominate at northern sites and that ozone levels tend to
dominate at southern sites. These results highlight the value
of long-term monitoring of radiation with multichannel radiometers to determine climatological data and evaluate the
combination of factors affecting ground UV radiation
A simple interferometric method to measure the calibration factor and displacement amplification in piezoelectric flextensional actuators
A interferometria laser constitui uma técnica consagrada para caracterizar atuadores piezoelétricos. Neste trabalho, utilizase um interferômetro de Michelson de baixo custo para mensurar o fator de calibração e a amplificação de deslocamento de um novo atuador piezoelétrico flextensional (APF), projetado através da técnica de otimização topológica. Um método simples, baseado na excitação do APF com sinal triangulare com baixa profundidade de modulação de fase óptica, permite realizara calibração absolutado interferômetro. Deslocamentos do APF para várias tensões de excitação são mensurados e a amplificação do deslocamento da piezocerâmica é determinada. A linearidade e a resposta em frequência do APF, até a frequência de 20 kHz, são avaliadasLaser interferometry is a well-established technique for the characterization of piezoelectric actuators. In this work, by using a low cost Michelson interferometer, the measurement of the calibration factor and the displacement amplification of a novel piezoelectric flextensional actuator (PFA), designed by using the topology optimization method, is performed. A simple method, based on small phase modulation depth when the PFA is driven by a triangular waveform, allows the absolute interferometer calibration. The free-displacement of the PFA for various drive voltages is measured and the displacement amplification is determined. The linearity and frequencyresponse of the PFA are evaluated up to 20 kHzFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Unesp Departamento de Engenharia ElétricaInstituto de Pesquisas Tecnológicas Centro de Metrologiade FluidosEPUSP Departamento de Mecatrônica e de Sistemas MecânicosUnesp Departamento de Engenharia Elétric
Encroachment of upland Mediterranean plant species in riparian ecosystems of southern Portugal
Sexual dimorphism in the mandible of the armadillo Chaetophractus villosus (Desmarest, 1804) (Dasypodidae) from northern Patagonia, Argentina
Cardiovascular events in chronic dialysis patients: emphasizing the importance of vascular disease prevention
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