Organometallic compounds - XIII. Topological representations of intramolecular rearrangements of six-coordinate structures

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Topological representations of intramolecular rearrangements of six-coordinate structures

info:eu-repo/semantics/publishe

Non-topological representation of intramolecular rearrangements of bipyramidal five-coordinate complexes

info:eu-repo/semantics/publishe

A review on assembly sequence planning and assembly line balancing optimisation using soft computing approaches

Assembly optimisation activities occur across development and production stages of manufacturing goods. Assembly Sequence Planning (ASP) and Assembly Line Balancing (ALB) problems are among the assembly optimisation. Both of these activities are classified as NP-hard. Several soft computing approaches using different techniques have been developed to solve ASP and ALB. Although these approaches do not guarantee the optimum solution, they have been successfully applied in many ASP and ALB optimisation works. This paper reported the survey on research in ASP and ALB that use soft computing approaches for the past 10years. To be more specific, only Simple Assembly Line Balancing Problem (SALBP) is considered for ALB. The survey shows that three soft computing algorithms that frequently used to solve ASP and ALB are Genetic Algorithm, Ant Colony Optimisation and Particle Swarm Optimisation. Meanwhile, the research in ASP and ALB is also progressing to the next level by integration of assembly optimisation activities across product development stages

Attenuated virulence of uridine-uracil auxotrophs of Aspergillus fumigatus

Aspergillus fumigatus mutants that are deficient in the de novo UMP biosynthesis pathway because of a mutation in the pyrG gene encoding orotidine-5'-phosphate decarboxylase (and therefore auxotrophic for uridine or uracil) were evaluated in a murine model of invasive aspergillosis. These mutants were entirely nonpathogenic, and mutant conidia remained ungerminated in alveolar macrophages. Both the germination and virulence defects could be restored by supplementing the drinking water of the animals with uridine. DNA-mediated transformation of one of the pyrG mutants with the Aspergillus niger pyrG gene also restored virulence. These results suggest that uridine and uracil are limiting in the lung environment, thus preventing conidium germination and hence virulence of the pyrG mutants.</jats:p