Search for molecular-genetic markers of risk germination hyperplastic processes in endometry combined with hysteromyoma

The results of studies of uterine fibroids in women. Studies on the role of combinations molecular-genetic markers of cytokines in germination hyperplastic processes combined with hysteromyoma are part of this studyye

Associations of Cytokines Genetic Variants with Myomatous Knots Sizes

The article presents study of cytokines molecular genetic markers’ impact on nature of uterus affection with myomatous knot

Analysis of Involvement of Cytokine Genetic Polymorphisms in Development of Genital Endometriosis

The article outlines the role of cytokines in development of genital endometriosis. There were detected associations between genetic polymorphisms and their combinations and development of genital endometriosis among women in the Central region of Russi

Humanization of education in the context of Janusz Korczak pedagogical ideas

© 2015, Review of European Studies. All right reserved. The article investigates the problems of humanization of education. It updates the main objectives and results of this process: direction of the process of children’s training and education in the development of the individual as an active subject of his perfection; change of the relationship in the dyad “adult-child”, in which each respects the dignity of the person and another takes his goals, needs and interests. As the education paradigm shift factor in modern Russia a positive educational experience is named. The article reveals the pedagogical concept and practice of a prominent Polish humanist educator Janusz Korczak. His ideas became the basis for the establishment in 1993 of Korczak integration camp “Nash Dom” (“Our House”). Educational work in the camp is built on the ideas of J. Korczak intrinsic value of childhood, child rights, the dialogue between adults and children as their dominant relationship of forgiveness as a basic principle of academic work, the attitude to the child not as an abstract figure, but as a particular person and his real life. The authors describe a 23-year-old experimental work of this camp, forms and methods of humanization of childhood space

Identical Functional Organization of Nonpolytene and Polytene Chromosomes in Drosophila melanogaster

Salivary gland polytene chromosomes demonstrate banding pattern, genetic meaning of which is an enigma for decades. Till now it is not known how to mark the band/interband borders on physical map of DNA and structures of polytene chromosomes are not characterized in molecular and genetic terms. It is not known either similar banding pattern exists in chromosomes of regular diploid mitotically dividing nonpolytene cells. Using the newly developed approach permitting to identify the interband material and localization data of interband-specific proteins from modENCODE and other genome-wide projects, we identify physical limits of bands and interbands in small cytological region 9F13-10B3 of the X chromosome in D. melanogaster, as well as characterize their general molecular features. Our results suggests that the polytene and interphase cell line chromosomes have practically the same patterns of bands and interbands reflecting, probably, the basic principle of interphase chromosome organization. Two types of bands have been described in chromosomes, early and late-replicating, which differ in many aspects of their protein and genetic content. As appeared, origin recognition complexes are located almost totally in the interbands of chromosomes

X Chromosome Sites Autonomously Recruit the Dosage Compensation Complex in Drosophila Males

It has been proposed that dosage compensation in Drosophila males occurs by binding of two core proteins, MSL-1 and MSL-2, to a set of 35–40 X chromosome “entry sites” that serve to nucleate mature complexes, termed compensasomes, which then spread to neighboring sequences to double expression of most X-linked genes. Here we show that any piece of the X chromosome with which compensasomes are associated in wild-type displays a normal pattern of compensasome binding when inserted into an autosome, independently of the presence of an entry site. Furthermore, in chromosomal rearrangements in which a piece of X chromosome is inserted into an autosome, or a piece of autosome is translocated to the X chromosome, we do not observe spreading of compensasomes to regions of autosomes that have been juxtaposed to X chromosomal material. Taken together these results suggest that spreading is not involved in dosage compensation and that nothing distinguishes an entry site from the other X chromosome sites occupied by compensasomes beyond their relative affinities for compensasomes. We propose a new model in which the distribution of compensasomes along the X chromosome is achieved according to the hierarchical affinities of individual binding sites