Border Terriers under primary veterinary care in England: demography and disorders

The Border Terrier is a working terrier type that is generally considered to be a relatively healthy and hardy breed. This study aimed to characterise the demography and common disorders of Border Terriers receiving veterinary care in England using de-identified electronic patient record data within the VetCompass™ Programme

Compiler-guided code restructuring for improving instruction TLB energy behavior

10th International Euro-Par Conference on Parallel Processing -- 2004 -- Pisa, ITALYThis paper presents a compiler-directed strategy for reducing energy consumption of instruction TLBs. The main idea is to restructure the code to increase the chances that one can generate virtual-to-physical address translation without going through the instruction TLB. The preliminary experimental results are promising.Univ Pisa, Dept Comp Sci,Natl Res Council Inst Informat Sci & Technologies,ACM,IEEE,IFI

Neuropsychiatric Approaches to Essential and Functional Tremor: A Comparative Study

Mehmet Balal,1 Soner Çakmak,2 Miray Erdem,3 Meltem Demirkiran4 1Department of Neurology, Çukurova University, Adana, 01330, Türkiye; 2Department of Psychiatry, Çukurova University, Adana, 01330, Türkiye; 3Department of Neurology, University of Health Sciences, Adana, 1370, Türkiye; 4Independent Researcher, Adana, 1120, TurkeyCorrespondence: Mehmet Balal, Department of Neurology, Çukurova University, Adana, 01330, Türkiye, Tel +90505 544 69 49, Email [email protected]: Differentiating essential tremor (ET) from functional tremor (FT) remains a challenge due to their overlapping clinical presentations. This study aimed to elucidate the demographic and psychometric differences between the aforementioned tremor types to enhance diagnostic accuracy and therapeutic strategies.Patients and Methods: This prospective study included 96 patients diagnosed with ET or FT and analysed their related demographic data, clinical symptoms, and psychometric evaluation scores. The statistical analysis involved Pearson’s chi-square tests, Fisher’s exact tests, and logistic regression to determine how the different variables impact tremor diagnosis.Results: Our study demonstrated a higher prevalence of ET in males (p = 0.015). Furthermore, we demonstrated that patients with ET displayed a significantly lower body mass index and a lower age of onset compared to those with FT (p = 0.050 and p = 0.023, respectively). Psychometric assessments revealed higher cognitive and body image scores in patients with ET, whereas those with FT scored higher on the depression and anxiety scales. The misdiagnosis rate was 14.5%, emphasising the requirement for improved diagnostic criteria.Conclusion: We established specific demographic and psychometric distinctions between ET and FT, which could potentially benefit clinicians in making accurate diagnoses and tailoring treatment approaches. These findings support the inclusion of comprehensive psychometric evaluations into standard diagnostic procedures to better differentiate tremor types.Plain Language Summary: Essential Tremor (ET) and Functional Tremor (FT) can be more accurately identified. Functional and Essential tremor are frequently misdiagnosed. Due to misdiagnosis of both diseases, treatment is often delayed and treatment costs increase. This study distinguishes between Essential and Functional Tremor by exploring gender, age, and psychometric variables, highlighting crucial differences and the significant issue of misdiagnosis, aiming to refine diagnostic criteria and treatment approaches. We identified distinct profiles for ET and FT, particularly in psychometric assessments where FT patients showed significantly higher anxiety and depression scores. Our study brings to light the importance of incorporating psychological evaluations in routine assessments, marking a significant advancement in tremor diagnosis and treatment. In addition, psychiatry and neurology emphasize that they need to cooperate more by following this patient group together. The expected future implications in clinical settings include improved diagnostic accuracy, personalized treatment plans based on detailed patient profiles, and a decrease in the misdiagnosis rates currently seen in tremor disorders.Keywords: essential tremor, functional tremor, neuropsychiatric evaluation, tremor diagnosi

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Diagnostic and prognostic role of TFF3, Romo-1, NF-кB and SFRP4 as biomarkers for endometrial and ovarian cancers: a prospective observational translational study

Purpose: This study aimed to evaluate trefoil factor 3 (TFF3), secreted frizzled-related protein 4 (sFRP4), reactive oxygen species modulator 1 (Romo1) and nuclear factor kappa B (NF-κB) as diagnostic and prognostic markers of endometrial cancer (EC) and ovarian cancer (OC). Methods: Thirty-one patients with EC and 30 patients with OC undergone surgical treatment were enrolled together with 30 healthy controls in a prospective study. Commercial ELISA kits determined serum TFF-3, Romo-1, NF-кB and sFRP-4 concentrations. Results: Serum TFF-3, Romo-1 and NF-кB levels were significantly higher in patients with EC and OC than those without cancer. Regarding EC, none of the serum biomarkers differs significantly between endometrial and non-endometrioid endometrial carcinomas. Mean serum TFF-3 and NF-кB levels were significantly higher in advanced stages. Increased serum levels of TFF-3 and NF-кB were found in those with a higher grade of the disease. Regarding OC, none of the serum biomarkers differed significantly among histological subtypes. Significantly increased serum levels of NF-кB were observed in patients with advanced-stage OC than those with stage I and II diseases. No difference in serum biomarker levels was found between those who had a recurrence and those who had not. The sensibility and specificity of these four biomarkers in discriminating EC and OC from the control group showed encouraging values, although no one reached 70%. Conclusions: TFF-3, Romo-1, NF-кB and SFRP4 could represent new diagnostic and prognostic markers for OC and EC. Further studies are needed to validate our results

Tissue-specific inflammation and insulin sensitivity in subjects with obesity

Obesity is associated with low-grade inflammation and insulin resistance (IR). The contribution of adipose tissue (AT) and hepatic inflammation to IR remains unclear. We conducted a study across three cohorts to investigate this relationship. The first cohort consists of six women with normal weight and twenty with obesity. In women with obesity, we found an upregulation of inflammatory markers in subcutaneous and visceral adipose tissue, isolated AT macrophages, and the liver, but no linear correlation with tissue-specific insulin sensitivity. In the second cohort, we studied 24 women with obesity in the upper vs lower insulin sensitivity quartile. We demonstrated that several omental and mesenteric AT inflammatory genes and T cell-related pathways are upregulated in IR, independent of BMI. The third cohort consists of 23 women and 18 men with obesity, studied before and one year after bariatric surgery. Weight loss following surgery was associated with downregulation of multiple immune pathways in subcutaneous AT and skeletal muscle, alongside notable metabolic improvements. Our results show that obesity is characterised by systemic and tissue-specific inflammation. Subjects with obesity and IR show a more pronounced inflammation phenotype, independent of BMI. Bariatric surgery-induced weight loss is associated with reduced inflammation and improved metabolic health.</p

Preoperative weight gain is not related to lower postoperative weight loss but to lower total weight loss up to 3 years after bariatric-metabolic surgery

Introduction: Weight loss prior to bariatric-metabolic surgery (BMS) is recommended in most bariatric centers. However, there is limited high-quality evidence to support mandatory preoperative weight loss. In this study, we will evaluate whether weight gain prior to primary BMS is related to lower postoperative weight loss.Methods: A retrospective analysis of prospectively collected data was performed. Preoperative weight loss (weight loss from start of program to day of surgery), postoperative weight loss (weight loss from day of surgery to follow-up), and total weight loss (weight loss from start of program to follow-up) were calculated. Five groups were defined based on patients' preoperative weight change: preoperative weight loss of >5 kg (group I), 3-5 kg (group II), 1-3 kg (group III), preoperative stable weight (group IV), and preoperative weight gain >1 kg (group V). Linear mixed models were used to compare the postoperative weight loss between group V and the other four groups (I-IV).Results: A total of 1928 patients were included. Mean age was 44 years, 78.6% were female, and preoperative BMI was 43.7 kg/m2. Analysis showed significantly higher postoperative weight loss in group V, compared to all other groups at 12, 24, and 36 months follow-up. Up to three years follow-up, highest total weight loss was observed in group I.Conclusion: Weight gain before surgery should not be a reason to withhold a bariatric-metabolic operation. However, patients with higher preoperative weight loss have higher total weight loss. Therefore, preoperative weight loss should be encouraged prior to bariatric surgery.</p