130 research outputs found

    Increasing risk of revision due to deep infection after hip arthroplasty: A study on 97,344 primary total hip replacements in the Norwegian Arthroplasty Register from 1987 to 2007

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    Background and purpose Over the decades, improvements in surgery and perioperative routines have reduced the incidence of deep infections after total hip arthroplasty (THA). There is, however, some evidence to suggest that the incidence of infection is increasing again. We assessed the risk of revision due to deep infection for primary THAs reported to the Norwegian Arthroplasty Register (NAR) over the period 1987–2007

    Reduced total energy expenditure and physical activity in cachectic patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids

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    The aim of the study was to assess the total energy expenditure (TEE), resting energy expenditure (REE) and physical activity level (PAL) in home-living cachectic patients with advanced pancreatic cancer. The influence of an energy and protein dense oral supplement either enriched with or without the n-3 fatty acid eicosapentaenoic acid (EPA) and administered over an 8-week period was also determined. In total, 24 patients were studied at baseline. The total energy expenditure was measured using doubly labelled water and REE determined by indirect calorimetry. Patients were studied at baseline and then randomised to either oral nutritional supplement. Measurements were repeated at 8 weeks. At baseline, REE was increased compared with predicted values for healthy individuals (1387(42) vs 1268(32) kcal day-1, P=0.001), but TEE (1732(82) vs 1903(48) kcal day-1, P=0.023) and PAL (1.24(0.04) vs 1.50) were reduced. After 8 weeks, the REE, TEE and PAL of patients who received the control supplement did not change significantly. In contrast, although REE did not change, TEE and PAL increased significantly in those who received the n-3 (EPA) enriched supplement. In summary, patients with advanced pancreatic cancer were hypermetabolic. However, TEE was reduced and this was secondary to a reduction in physical activity. The control energy and protein dense oral supplement did not influence the physical activity component of TEE. In contrast, administration of the supplement enriched with EPA was associated with an increase in physical activity, which may reflect improved quality of life

    Tropical field stations yield high conservation return on investment

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    Conservation funding is currently limited; cost-effective conservation solutions are essential. We suggest that the thousands of field stations worldwide can play key roles at the frontline of biodiversity conservation and have high intrinsic value. We assessed field stations’ conservation return on investment and explored the impact of COVID-19. We surveyed leaders of field stations across tropical regions that host primate research; 157 field stations in 56 countries responded. Respondents reported improved habitat quality and reduced hunting rates at over 80% of field stations and lower operational costs per km2 than protected areas, yet half of those surveyed have less funding now than in 2019. Spatial analyses support field station presence as reducing deforestation. These “earth observatories” provide a high return on investment; we advocate for increased support of field station programs and for governments to support their vital conservation efforts by investing accordingly

    Tropical field stations yield high conservation return on investment

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    Conservation funding is currently limited; cost-effective conservation solutions are essential. We suggest that the thousands of field stations worldwide can play key roles at the frontline of biodiversity conservation and have high intrinsic value. We assessed field stations’ conservation return on investment and explored the impact of COVID-19. We surveyed leaders of field stations across tropical regions that host primate research; 157 field stations in 56 countries responded. Respondents reported improved habitat quality and reduced hunting rates at over 80% of field stations and lower operational costs per km2 than protected areas, yet half of those surveyed have less funding now than in 2019. Spatial analyses support field station presence as reducing deforestation. These “earth observatories” provide a high return on investment; we advocate for increased support of field station programs and for governments to support their vital conservation efforts by investing accordingly

    Nicotinic acetylcholine receptors in attention circuitry: the role of layer VI neurons of prefrontal cortex

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    Testing the reproducibility of active-distributed temperature sensing for measuring groundwater specific discharge beneath a braided river

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    Braided rivers are a major contributor of groundwater recharge, yet little is known about how recharge rates vary in time. Existing methods for estimating groundwater recharge from rivers (i.e., river loss) are inadequate for studying highly heterogeneous braided river systems at a sufficient spatiotemporal resolution. To do so, active-distributed temperature sensing (A-DTS) is employed, which combines fibre optic temperature measurements with an active heat source, enabling high-resolution quantification of water fluxes. In this study, twelve successive A-DTS surveys were conducted during a 24-hour experiment on a 100 m horizontal subsurface hybrid fibre optic cable installed at 5 m depth beneath a braided river. The experiment was carried out under conditions where the river stage and flow were relatively stable to demonstrate the reproducibility and effectiveness of the A-DTS method for measuring groundwater specific discharge. This foundational work will provide a high level of confidence in the method for future studies aimed at evaluating temporal variations in groundwater recharge. The median groundwater specific discharge values calculated over the 24-hour period had a very narrow range from 3.5 to 4.0 m d‾¹ across the wetted footprint of the river, which is within the measurement error of the installation (6 %), indicating relatively stable groundwater recharge during the experiment. This provides confidence in the repeatability of the A-DTS method as an effective technology for quantifying river loss over longer time periods, to understand seasonal variability of groundwater recharge in braided river systems

    Active-distributed temperature sensing dataset beneath a braided river

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    Braided rivers play a significant role in replenishing groundwater, but our understanding of how these recharge rates fluctuate over time remains limited. Traditional techniques for gauging groundwater recharge are ineffective for studying complex braided river systems due to their insufficient spatiotemporal resolution. To address this gap, active-distributed temperature sensing (A-DTS) was used. This method combines fiber optic temperature measurements with an active heat source, enabling quantification of groundwater fluxes. In this study, twelve consecutive A-DTS surveys were conducted on a 100 m long hybrid fiber optic cable to a depth of 5 m beneath the Waikirikiri Selwyn River. This experiment was conducted during a period of relatively stable river stage and flow, highlighting the effectiveness of using A-DTS to measure temporal changes in groundwater recharge

    Active distributed temperature sensing to assess surface water–groundwater interaction and river loss in braided river systems

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    Braided river systems are continuously changing environments, comprising heterogeneous gravel-forming meandering channels and bars, and dynamic surface water–groundwater (SW–GW) interactions. In alluvial aquifers associated with braided rivers, river leakage is volumetrically the most important source of groundwater recharge, yet neither the leakage process or recharge rates are well understood. Insights into how braided river systems recharge underlying braidplain aquifers during different hydrological conditions, and how this can be measured, is of critical concern for river management practices. Innovative field techniques using heat as a tracer can be applied to spatially map and quantify the temporal changes of SW–GW interaction and the processes and mechanisms of groundwater recharge for different flow regimes. Horizontal directional drilling was used to construct two 100 m long drillholes at a depth of ∼ 5 m beneath and perpendicular to the river channel at a field site on the Waikirikiri Selwyn River, South Island, New Zealand. The two drillholes were completed with a hybrid fibre optic cable, containing four multi-mode fibres and 2x18AWG copper conductors. A Silixa XT-DTS™ distributed temperature sensor unit combined with a Silixa Heat Pulse System, was used to collect active distributed temperature sensing (A-DTS) measurements along both cables. Results from two A-DTS surveys showed distinct temperature changes across the active river channel indicating spatial variability in river loss and preferential groundwater recharge pathways to the shallow braidplain aquifer. The average groundwater velocity was 14 m d¯¹. The average calculated river loss at the survey sites was 21 m³ d¯¹ m¯¹ compared to 25 – 26 m³ d¯¹ m¯¹ that was measured using differential flow gauging conducted during the same time period. The horizontal installation of the fibre optic cable and the A-DTS method provided valuable insights into SW–GW exchange between the Waikirikiri Selwyn River and shallow braidplain aquifer and how the river leakage rates varied spatially across the river channel
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