Splitting electronic spins with a Kondo double dot device

We present a simple device made of two small capacitively coupled quantum dots in parallel. This set-up can be used as an efficient "Stern-Gerlach" spin filter, able to simultaneously produce, from a normal metallic lead, two oppositely spin-polarized currents when submitted to a local magnetic field. Our proposal is based on the realization of a Kondo effect where spin and orbital degrees of freedom are entangled, allowing a spatial separation between the two spin polarized currents. In the low temperature Kondo regime, the efficiency is very high and the device conductance reaches the unitary limit, $\frac{e^2}{h}$ per spin branch.Comment: 3 pages, 2 figure

Effects of low incubation temperatures on the bactericidal activity of anti-tuberculosis drugs

OBJECTIVES: to explore the effect of low incubation temperatures and the consequent slowing of bacterial metabolism on the bactericidal action of anti-tuberculosis drugs against Mycobacterium tuberculosis. METHODS: counting of surviving bacteria during exposure of static cultures to 1 mg/L isoniazid, 2 mg/L rifampicin, 0.5 or 2 mg/L TMC207 and 40 or 160 mg/L pyrazinamide, usually for periods of 21 days at temperatures of 37, 25, 22, 19, 16 or 8°C. RESULTS: the bactericidal activities of isoniazid and rifampicin were progressively reduced at 25 and 22°C, and were minimal at lower temperatures. TMC207 was immediately bactericidal at 37°C, in contrast to the early static phase reported with log phase cultures, and showed less change in activity as incubation temperatures were reduced than did rifampicin or isoniazid. Pyrazinamide was more bactericidal when incubation temperatures were reduced below 37°C and when the static seed cultures were most dormant. CONCLUSIONS: these results can be explained by the surmise that at low temperatures bacterial energy is at a low level with only just sufficient ATP to maintain homeostasis, making the bacteria more susceptible to the blocking of ATP synthesis by TMC207. Insufficient ATP at low temperature would also hinder the export of pyrazinoic acid, the toxic product of the pro-drug pyrazinamide, from the mycobacterial cell by an inefficient efflux pump that requires energ

Spin-orbital Kondo decoherence by environmental effects in capacitively coupled quantum dot devices

Strong correlation effects in a capacitively coupled double quantum-dot setup were previously shown to provide the possibility of both entangling spin-charge degrees of freedom and realizing efficient spin-filtering operations by static gate-voltage manipulations. Motivated by the use of such a device for quantum computing, we study the influence of electromagnetic noise on a general spin-orbital Kondo model, and investigate the conditions for observing coherent, unitary transport, crucial to warrant efficient spin manipulations. We find a rich phase diagram, where low-energy properties sensitively depend on the impedance of the external environment and geometric parameters of the system. Relevant energy scales related to the Kondo temperature are also computed in a renormalization-group treatment, allowing to assess the robustness of the device against environmental effects.Comment: 13 pages, 13 figures. Minor modifications in V

Reading sentences of uniform word length: evidence for the adaptation of the preferred saccade length during reading

In the current study we investigated the effect of removing word length variability within sentences on spatial aspects of eye movements during reading. Participants read sentences that were uniform in terms of word length, with each sentence consisting entirely of three, four, or five letter words, or a combination of these word lengths. Several interesting findings emerged. Adaptation of the preferred saccade length occurred for sentences with different uniform word length; participants would be more accurate at making short saccades while reading uniform sentences of three letter words, while they would be more accurate at making long saccades while reading uniform sentences of five letter words. Furthermore, word skipping was affected such that three and four letter words were more likely, and five letter words less likely, to be directly fixated in uniform compared to non-uniform sentences. It is argued that saccadic targeting during reading is highly adaptable and flexible towards the characteristics of the text currently being read, as opposed to the idea implemented in most current models of eye movement control during reading that readers develop a preference for making saccades of a certain length across a lifetime of experience with a given language<br/

Influence of a pulsed laser regime on surface finish induced by thedirect metal deposition process on a Ti64 alloy

tThe direct metal deposition (DMD) laser technique is a free-form metal deposition process, which allowsgenerating a prototype or small series of near net-shape structures. Despite numerous advantages, oneof the most critical issues of the technique is that produced pieces have a deleterious surface finish whichrequires post machining steps. Following recent investigations where the use of laser pulses instead of acontinuous regime was successful to obtain smoother DMD structures, this paper relates investigationson the influence of a pulsed laser regime on the surface finish induced by DMD on a widely used titaniumalloy (Ti64). Findings confirm that using high mean powers improves surface finish but also indicate aspecific effect of the laser operating mode: using a quasi-continuous pulsed mode instead of fully-cw laserheating is an efficient way for surface finish improvement. For similar average powers, the use of a pulsedmode with large duty cycles is clearly shown to provide smoothening effects. The formation of larger andstable melt pools having less pronounced lateral curvatures, and the reduction of thermal gradients andMarangoni flow in the external side of the fusion zone were assumed to be the main reasons for surfacefinish improvement. Additional results indicate that combining the benefits from a pulsed regime and auniform laser irradiation does not provide further reduction of surface roughness

Influence of various process conditions on surface finishes induced by the direct metal deposition laser technique on a Ti–6Al–4V alloy

The direct metal deposition (DMD) with laser is a free-form metal deposition process for manufacturing dense pieces, which allows generating a prototype or small series of near net-shape structures. One of the most critical issues is that produced pieces have a deleterious surface finish which systematically requires post machining steps. This problem has never been fully addressed before. The present work describes investigations on the DMD process, using an Yb-YAG disk laser, and a widely used titanium alloy (Ti–6Al–4V) to understand the influence of the main process parameters on the surface finish quality. The focus of our work was: (1) to understand the physical mechanisms responsible for deleterious surface finishes, (2) to propose different experimental solutions for improving surface finish. In order to understand the physical mechanisms responsible for deleterious surface finishes, we have carried out: (1) a precise characterization of the laser beam and the powder stream; (2) a large number of multi-layered walls using different process parameters (P(W), V(m/min), Dm (g/min), Gaussian or uniform beam distribution); (3) a real time fast camera analysis of melt pool dynamics and melt-pool – powder stream coupling; (4) a characterization of wall morphologies versus process parameters using 2D and 3D profilometry. The results confirm that surface degradation depends on two distinct aspects: the sticking of nonmelted or partially melted particles on the free surfaces, and the formation of menisci with more or less pronounced curvature radii. Among other aspects, a reduction of layer thickness and an increase of melt-pool volumes to favor re-melting processes are shown to have a beneficial effect on roughness parameters. Last, a simple analytical model was proposed to correlate melt-pool geometries to resulting surface finishes

Investigating eye movement acquisition and analysis technologies as a causal factor in differential prevalence of crossed and uncrossed fixation disparity during reading and dot scanning

Previous studies examining binocular coordination during reading have reported conflicting results in terms of the nature of disparity (e.g. Kliegl, Nuthmann, &amp; Engbert (Journal of Experimental Psychology General 135:12-35, 2006); Liversedge, White, Findlay, &amp; Rayner (Vision Research 46:2363-2374, 2006). One potential cause of this inconsistency is differences in acquisition devices and associated analysis technologies. We tested this by directly comparing binocular eye movement recordings made using SR Research EyeLink 1000 and the Fourward Technologies Inc. DPI binocular eye-tracking systems. Participants read sentences or scanned horizontal rows of dot strings; for each participant, half the data were recorded with the EyeLink, and the other half with the DPIs. The viewing conditions in both testing laboratories were set to be very similar. Monocular calibrations were used. The majority of fixations recorded using either system were aligned, although data from the EyeLink system showed greater disparity magnitudes. Critically, for unaligned fixations, the data from both systems showed a majority of uncrossed fixations. These results suggest that variability in previous reports of binocular fixation alignment is attributable to the specific viewing conditions associated with a particular experiment (variables such as luminance and viewing distance), rather than acquisition and analysis software and hardware.<br/

Meta-Learning by the Baldwin Effect

The scope of the Baldwin effect was recently called into question by two papers that closely examined the seminal work of Hinton and Nowlan. To this date there has been no demonstration of its necessity in empirically challenging tasks. Here we show that the Baldwin effect is capable of evolving few-shot supervised and reinforcement learning mechanisms, by shaping the hyperparameters and the initial parameters of deep learning algorithms. Furthermore it can genetically accommodate strong learning biases on the same set of problems as a recent machine learning algorithm called MAML "Model Agnostic Meta-Learning" which uses second-order gradients instead of evolution to learn a set of reference parameters (initial weights) that can allow rapid adaptation to tasks sampled from a distribution. Whilst in simple cases MAML is more data efficient than the Baldwin effect, the Baldwin effect is more general in that it does not require gradients to be backpropagated to the reference parameters or hyperparameters, and permits effectively any number of gradient updates in the inner loop. The Baldwin effect learns strong learning dependent biases, rather than purely genetically accommodating fixed behaviours in a learning independent manner