Increasing New Orienting Emergency Department Nurses\u27 Awareness of Mass Casualty Incident Emergency Preparedness and Disaster Response Core Competencies to Improve Mass Casualty Incident Response

Mass casualty incidents (MCI) impose a substantial threat to healthcare. Despite the increasing frequency of MCIs many healthcare organizations and nursing programs do not adequately prepare nurses to be effective responders during an MCI. This evidence-based practice pilot project was purposed to increase new orienting emergency department nurses’ confidence and ability to effectively respond to an MCI. This project involved implementing an MCI educational program consisting of a disaster nursing framework to educate new orienting emergency department nurses on emergency preparedness and disaster response core competencies. The project leader utilized a quasi-experimental design to collect data pre- and post-intervention utilizing a modified Emergency Preparedness Information Questionnaire (EPIQ). The measurable outcomes for the project included improvement in awareness of competencies relate to MCI emergency preparedness, awareness of competencies related to disaster response, and level of self-reported confidence to respond to MCIs. This project revealed a statistically significant improvement in the awareness of emergency preparedness and disaster response core competencies among new orienting emergency department nurses as well as enhanced self-reported confidence to respond to an MCI. The results of this project have important implications for enhancing MCI education for nurses to develop prepared and effective responses to MCIs

Latinobarómetro 2021 como discurso objeto. Tensiones significantes entre la democracia poliárquica y la democracia en Castoriadis.

El informe Latinobarómetro (en adelante, LATB) se ha constituido en una fuente de recurrente consulta sobre la democracia en la región latinoamericana a lo largo de 25 años. Su expresa valoración en términos de una democracia “churchilliana” representada como la forma preferible de gobierno respecto de las otras conocidas, nos remite a una concepción procedimental y de tipo poliárquico emparentada con la forma institucional recuperada hace cuatro décadas en Argentina, y hoy condicionada y en riesgo de ruptura bajo nuevas formas. En ese contexto, nos proponemos socializar algunas reflexiones que pro-muevan la interrogación democrática confrontando dos visiones: una procedimental-poliárquica y asociada al sentido común y otra sustantiva y contrahegemónica, mediante la puesta en “tensión significante” de algunas dimensiones del informe con las categorías centrales de la democracia en Castoriadis. Este contrapunto nos permitirá, además, analizar algunos elementos propios de la situación argentina actual.Para ello, hemos organizado el trabajo en cinco apartados, dentro de los cuales esta introducción es el primero. En el segundo, se abordan y explicitan algunas cuestiones que hacen al marco teórico-metodológico del trabajo. En el tercero, se presenta una síntesis de la cuestión de la democracia procedimental y la democracia sustantiva, como encuadre general en el que se insertan las tres tensiones significantes que se analizan en el cuarto apartado. Como cierre, algunas reflexiones y conclusiones que sugiere el análisis con el objetivo que sirvan para ejercitar la interrogación democrática.Fil: Deramo, Daniel Eduardo. Universidad Nacional de Tres de Febrero. Instituto de Est. Interd. En Der. Soc. y Relac. del Trabajo; ArgentinaFil: Lobato, Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tierra del Fuego. Instituto de Cultura, Sociedad y Estado; Argentin

Resolution of the ATLAS muon spectrometer monitored drift tubes in LHC Run 2

The momentum measurement capability of the ATLAS muon spectrometer relies fundamentally on the intrinsic single-hit spatial resolution of the monitored drift tube precision tracking chambers. Optimal resolution is achieved with a dedicated calibration program that addresses the specific operating conditions of the 354 000 high-pressure drift tubes in the spectrometer. The calibrations consist of a set of timing offsets and drift time to drift distance transfer relations, and result in chamber resolution functions. This paper describes novel algorithms to obtain precision calibrations from data collected by ATLAS in LHC Run 2 and from a gas monitoring chamber, deployed in a dedicated gas facility. The algorithm output consists of a pair of correction constants per chamber which are applied to baseline calibrations, and determined to be valid for the entire ATLAS Run 2. The final single-hit spatial resolution, averaged over 1172 monitored drift tube chambers, is 81.7 +/- 2.2 mu m

Search for light resonances decaying to boosted quark pairs and produced in association with a photon or a jet in proton-proton collisions at √s=13 TeV with the ATLAS detector

This Letter presents a search for new light resonances decaying to pairs of quarks and produced in association with a high-pT photon or jet. The dataset consists of proton–proton collisions with an integrated luminosity of 36.1 fb−1 at a centre-of-mass energy of √s=13 TeV recorded by the ATLAS detector at the Large Hadron Collider. Resonance candidates are identified as massive large-radius jets with substructure consistent with a particle decaying into a quark pair. The mass spectrum of the candidates is examined for local excesses above background. No evidence of a new resonance is observed in the data, which are used to exclude the production of a lepto-phobic axial-vector Z′boson

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Measurement of the inclusive cross-section for the production of jets in association with a Z boson in proton-proton collisions at 8 TeV using the ATLAS detector

The inclusive cross-section for jet production in association with a Z boson decaying into an electron–positron pair is measured as a function of the transverse momentum and the absolute rapidity of jets using 19.9 fb −1 of s√=8 TeV proton–proton collision data collected with the ATLAS detector at the Large Hadron Collider. The measured Z + jets cross-section is unfolded to the particle level. The cross-section is compared with state-of-the-art Standard Model calculations, including the next-to-leading-order and next-to-next-to-leading-order perturbative QCD calculations, corrected for non-perturbative and QED radiation effects. The results of the measurements cover final-state jets with transverse momenta up to 1 TeV, and show good agreement with fixed-order calculations

Rational design and synthesis of modified teixobactin analogues: in vitro antibacterial activity against Staphylococcus aureus, Propionibacterium acnes and Pseudomonas aeruginosa

Teixobactin, a recently discovered depsipeptide that binds to bacterial lipid II and lipid III, provides a promising molecular scaffold for the design of new antimicrobials. Herein, we describe the synthesis and antimicrobial evaluation of systematically modified teixobactin analogues. The replacement of Ile11 residue with aliphatic isosteres, the modification of the guanidino group at residue 10 and the introduction of a rigidifying residue, dehydroamino acid into the macrocyclic ring generated useful structure‐activity information. Extensive antimicrobial susceptibility assessment against a panel of clinically relevant Staphylococcus aureus and Propionibacterium acnes led to the identification of a new lead compound, [Arg(Me)10,Nle11]teixobactin 63, with excellent bactericidal activity (MIC 2‐4 μg/mL). Significantly, the antimicrobial activity of several of the teixobactin analogues against the pathogenic Gram‐negative Pseudomonas aeruginosa was 'restored' when combined with sub‐MIC concentration of the outer membrane‐disruptive antibiotic, colistin. The antimicrobial effectiveness of [Tfn10,Nle11]teixobactin 66 (32 μg/mL)‐colistin (2 μg/mL; 0.5x MIC) combination against P. aeruginosa PAO1 reveal, for the first time, an alternative therapeutic option in the treatment of Gram‐negative infections