Study of pressure losses in tubing and fittings Quarterly progress report, Dec. 1965 - Feb. 1966

Pressure losses in tubing and fittings - flow systems analysis, entrance effects in flexible metal hoses, and methods for analyzing flow over rough surfac

15 GHz quadrature voltage controlled oscillator in 130 nm CMOS technology

This paper reports a 15 GHz quadrature voltage controlled oscillator (QVCO) designed in a 130 nm CMOS technology. The phase noise performance of the QVCO and of a phase locked loop (PLL) where the QVCO was inserted were compared with the literature and with telecom standards and commercial products for broadcast satellite applications

Prediction of electron density and collision cross section. Volume 2 - Equilibrium electron density prediction, a mathematical model Final report

Mathematical model for prediction of electron density at equilibriu

Understanding the biochemical alterations in cancer cells chronically treated with PI3K/mTOR inhibitors

PhDThe PI3K/mTOR signalling pathway plays a major role in biology and disease. Therefore, effective inhibitors that target proteins of this pathway have been developed. However, acquired resistance of cancer cells is a prevalent phenomenon that limits the durable response of these compounds. It is becoming apparent that experimental approaches for comprehensive biochemical analysis contribute to understand the complex mechanisms that confer drug resistance, and advances in largescale technologies including genomic sequencing and proteomics allow unprecedented molecular coverage without being biased for specific genes/cellular pathways. Initially, the phenotypic response of sensitive and resistant cells to the absence or presence of a PI3K inhibitor (PI3Ki), as well as other kinases, was examined. This study revealed that PI3Ki-resistant cells experience extensive phenotypic changes upon withdrawal of the PI3Ki from the culture media. The regulation of the proteome and phosphoproteome of sensitive and PI3Ki-resistant cells grown with or without the PI3Ki was analysed by shotgun mass spectrometry-based label-free quantitative technology. This analysis demonstrated that the proteomes and phosphoproteomes of drug-resistant cells are remodelled conditional to the presence of PI3Ki, and that the levels of enzymes with metabolic roles are modulated in resistant cells. Functional analysis of the metabolism of cells capable to survive in absence of PI3K/mTOR activity demonstrated that the bioenergetic activity of these cells is contingent on the presence of the selection drug. The complete set of protein-coding regions of the genome (exome) of sensitive and PI3Ki-resistant cells was then sequenced. This study unveiled common alterations in exome regions across PI3Kiresistant cell lines, as well as a degree of genomic heterogeneity between them. Lastly, the impact of lactic acid, a metabolic product, on a defined signalling network of the MCF7 breast cancer cell line was analysed. This study described the capacity of this metabolite to change the activity of signalling network branches

Soft Budget Constraints in French Football through Public Financing of Stadiums

Several football stadiums were built or renovated in France for hosting the 2016 UEFA European Football Championship. This study examines to what extent financial support by local governments for stadium construction or renovation induces soft budget constraints (SBC) for professional sports clubs. We address the research question based on a quantitative case study in the context of the construction and renovation of eight football stadiums that took place in France between 2012 and 2016. Our data shows that the public sector financed on average 78% of the new stadiums’ total construction or renovation costs, and local governments paid on average 60% of the total annual rental costs. The results indicate that local governments in French professional football are “supporting organizations” and help to ensure the financial sustainability and viability of the clubs by allowing them to benefit from financial flexibility, which are typical characteristics of SBCs. In total, we identify 32 forms of public aid that we classified according to different categories of “softness” and whether these aids appeared ex ante or ex post. Public aid constituted financial support that was sometimes very substantial, amounting to several million euros in each case. This financial support is often not taken into account by the regulatory authorities and thus could be interpreted as hidden government subsidies to professional clubs, which in some cases exceeded the subsidy allowance of €2.3 million

Meningitis post traumática y penicilina

Presented at session 4th April 1945Presentado en sesión de 4 de abril de 194

Insolvency in French Soccer: The Case of Payment Failure

This article examines insolvency (payment failure) in the top three divisions of French soccer. Between 1970 and 2014, we observed 79 cases of insolvency arising from participation in the top two or three (since 1993) divisions. We find that demand (attendance) shocks can account for insolvency to a significant degree. We also find that insolvency can be explained by club status and ownership structure, with professional status and the association structure being more likely to lead to insolvency. We also examine the postinsolvency performance of soccer clubs and find that the adverse consequences of insolvency are long lasting

Effet nouveau stade : une lune de miel perturbée

International audienceAnnoncés comme l’outil indispensable au développement du football français, les nouveaux stades permettent-ils, à l’instar du succés allemand, d’assurer en France l’évolution économique des clubs professionnels ? Analyse comparée entre deux nations fortes du football européen