HIF- and Non-HIF-Regulated Hypoxic Responses Require the Estrogen-Related Receptor in Drosophila melanogaster

Low-oxygen tolerance is supported by an adaptive response that includes a coordinate shift in metabolism and the activation of a transcriptional program that is driven by the hypoxia-inducible factor (HIF) pathway. The precise contribution of HIF-1a in the adaptive response, however, has not been determined. Here, we investigate how HIF influences hypoxic adaptation throughout Drosophila melanogaster development. We find that hypoxic-induced transcriptional changes are comprised of HIF-dependent and HIF-independent pathways that are distinct and separable. We show that normoxic set-points of carbohydrate metabolites are significantly altered in sima mutants and that these animals are unable to mobilize glycogen in hypoxia. Furthermore, we find that the estrogen-related receptor (dERR), which is a global regulator of aerobic glycolysis in larvae, is required for a competent hypoxic response. dERR binds to dHIFa and participates in the HIF-dependent transcriptional program in hypoxia. In addition, dERR acts in the absence of dHIFa in hypoxia and a significant portion of HIF-independent transcriptional responses can be attributed to dERR actions, including upregulation of glycolytic transcripts. These results indicate that competent hypoxic responses arise from complex interactions between HIF-dependent and -independent mechanisms, and that dERR plays a central role in both of these programs

Not All Explanations Predict Satisfactorily, and Not All Good Predictions Explain

This short comment on Epstein's (2008) paper and on the response by Thompson and Derr argues that the symmetry between explanation and prediction cannot satisfactorily be discussed without making clear what prediction means - depending on which connotations the authors have with 'prediction' their arguments can or cannot be accepted.[No keywords]

Heated bimetal strip prevents damage of bearings by vibration

Strip of bimetal is shaped as split ring; when properly fabricated from thin sheet, width of strip increases when it is heated. When width of strip increases, outer races are forced apart, thus pressing balls tightly against inner races. Strip applies axial load to bearing, amount of load being function of temperature to which strip is heated

Electrostatically controlled heat shutter

A heat transfer assembly for conducting thermal energy is described. The assembly includes a hermetically sealed container enclosing a quantity of inert gas such as nitrogen. Two opposed walls of the container have high thermal conducting characteristics while the connecting walls have low thermal conducting characteristics. Electrodes are positioned adjacent to the high thermal conducing walls and biased relative to the conducting walls to a corona potential for creating an ionic gas wind which must contact the conducting walls to be neutralized. The contact of the gas molecules permits the maximum thermal energy transfer between the walls. Baffles can be positioned adjacent to the electrodes to regulate gas flow between the high thermal conducting surfaces

On uniform continuous dependence of solution of Cauchy problem on a parameter

Suppose that an $n$-dimensional Cauchy problem \frac{dx}{dt}=f(t,x,\mu) (t \in I, \mu \in M), x(t_0)=x^0 satisfies the conditions that guarantee existence, uniqueness and continuous dependence of solution x(t,t_0,\mu) on parameter \mu in an open set M. We show that if one additionally requires that family \{f(t,x,\cdot)\}_{(t,x)} is equicontinuous, then the dependence of solution x(t,t_0,\mu) on parameter \mu \in M is uniformly continuous. An analogous result for a linear n \times n-dimensional Cauchy problem \frac{dX}{dt}=A(t,\mu)X+\Phi(t,\mu) (t \in I, \mu \in M), X(t_0,\mu)=X^0(\mu) is valid under the assumption that the integrals \int_I\|A(t,\mu_1)-A(t,\mu_2)\|dt and \int_I \|\Phi(t,\mu_1)-\Phi(t,\mu_2)\|dt can be made smaller than any given constant (uniformly with respect to \mu_1, \mu_2 \in M) provided that \|\mu_1-\mu_2\| is sufficiently small

Partial normalizations of coxeter arrangements and discriminants

We study natural partial normalization spaces of Coxeter arrangements and discriminants and relate their geometry to representation theory. The underlying ring structures arise from Dubrovin’s Frobenius manifold structure which is lifted (without unit) to the space of the arrangement. We also describe an independent approach to these structures via duality of maximal Cohen–Macaulay fractional ideals. In the process, we find 3rd order differential relations for the basic invariants of the Coxeter group. Finally, we show that our partial normalizations give rise to new free divisors

Distributions with dynamic test functions and multiplication by discontinuous functions

As follows from the Schwartz Impossibility Theorem, multiplication of two distributions is in general impossible. Nevertheless, often one needs to multiply a distribution by a discontinuous function, not by an arbitrary distribution. In the present paper we construct a space of distributions where the general operation of multiplication by a discontinuous function is defined, continuous, commutative, associative and for which the Leibniz product rule holds. In the new space of distributions, the classical delta-function $\delta_\tau$ extends to a family of delta-functions $\delta_\tau^\alpha$, dependent on the \textit{shape} $\alpha$. We show that the various known definitions of the product of the Heaviside function and the delta-function in the classical space of distributions $\mathcal D'$ become particular cases of the multiplication in the new space of distributions, and provide the applications of the new space of distributions to the ordinary differential equations which arise in optimal control theory. Also, we compare our approach of the Schwartz distribution theory with the approach of the Colombeau generalized functions algebra, where the general operation of multiplication of two distributions is defined

Improving LIGO calibration accuracy by tracking and compensating for slow temporal variations

Calibration of the second-generation LIGO interferometric gravitational-wave detectors employs a method that uses injected periodic modulations to track and compensate for slow temporal variations in the differential length response of the instruments. These detectors utilize feedback control loops to maintain resonance conditions by suppressing differential arm length variations. We describe how the sensing and actuation functions of these servo loops are parameterized and how the slow variations in these parameters are quantified using the injected modulations. We report the results of applying this method to the LIGO detectors and show that it significantly reduces systematic errors in their calibrated outputs.Comment: 13 pages, 8 figures. This is an author-created, un-copyedited version of an article published in Classical and Quantum Gravity. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from i