BAVIERA (Alemania). Estrategia militar (1825). 1:500000

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Role of T-type calcium current in identified D-hair mechanoreceptor neurons studied in vitro

Different subsets of dorsal root ganglion (DRG) mechanoreceptors transduce low- and high-intensity mechanical stimuli. It was shown recently that, in vivo, neurotrophin-4 (NT-4)-dependent D-hair mechanoreceptors specifically express a voltage-activated T-type calcium channel (Ca(v)3.2) that may be required for their mechanoreceptive function. Here we show that D-hair mechanoreceptors can be identified in vitro by a rosette-like morphology in the presence of NT-4 and that these rosette neurons are almost all absent in DRG cultures taken from NT-4 knock-out mice. In vitro identification of the D-hair mechanoreceptor allowed us to explore the electrophysiological properties of these cells. We demonstrate that the T-type Ca(v)3.2 channel induced slow membrane depolarization that contributes to lower the voltage threshold for action potential generation and controls spike latency after stimulation of D-hair mechanoreceptors. Indeed, the properties of the T-type amplifier are particularly well suited to explain the high sensitivity of D-hair mechanoreceptors to slowly moving stimuli

BAVIERA (Alemania). Estrategia militar (1825). 1:4000

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BADEN-WURTEMBERG (Alemania). 1:40000

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BADEN-WURTEMBERG (Alemania). Estrategia militar (1825). 1:35000

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BAVIERA (Alemania). 1:80000

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BAVIERA (Alemania). 1:5000

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Diálogo 3: Reforma al Código de Aguas

This text is an edited version of the conversation held by some of the members of the journals's editorial team with Professor Tatiana Celume and Professors Matías Desmadryl and Winston Alburquenque, who officiated as moderator. The conversation was held on August 22, 2019 at the LLM UC Master’s premises.Se presenta una versión editada de la conversación sostenida por algunos de los miembros del comité de redacción de la revista con la profesora Tatiana Celume y los profesores Matías Desmadryl y Winston Alburquenque, quien ofició como moderador. La conversación se llevó a cabo el 22 de agosto de 2019 en dependencias del Magíster LLM UC