EXPERIMENTAL STUDY OF HYDRODYNAMICS ON ARROWS

Athletes' technical skill must be matched with appropriate equipment if an archer ,is to be successful. A lot of key skills of archery are determined by the features of aerodynamics of a flying arrow. Therefore, the performance of bow and arrow and the understanding of them have a direct impact on archery skill and competition Iresult. Water and wind tunnel testing of arrows to establish their hydrodynamic characteristics are needed if performance is to be optimized

A Review of Geometric Reconstruction Algorithm and Repairing Methodologies for Gas Turbine Components

Repairing of the used gas turbine components is becoming a challenge due to continual increase in manufacturing costs and the complex geometry. This paper discusses research on the repairing solutions for the damaged ones. The various kinds of geometric reconstruction algorithm for those are introduced selectively from the cross-section of the blade because of its vital roles. However, owing to the limitation of the algorithm, it has been lack of an efficient approach for reconstructing the geometry of a blade. As a result of this study, future research directions are highlighted. DOI: http://dx.doi.org/10.11591/telkomnika.v11i3.231

Multi-disease transcriptomic analysis of sex hormone genes reveals a novel prognostic model for thyroid cancer with breast cancer correlations

BackgroundThere is a potential bidirectional pathogenicity between thyroid and breast cancers. The association between sex hormones and two types of malignant tumors has emerged as a topic of intense academic debate in recent years. However, the role of sex hormone metabolism-related genes in thyroid cancer still needs to be further explored.MethodsWe obtained thyroid and breast cancer transcriptome data from the TCGA database and sex hormone metabolism-related gene sets from the MSigDB database, thus screening for sex hormone metabolism-related genes linked to the two malignant tumors. Univariate cox regression analysis was used for the screening of disease-free survival (DFS)-associated genes. The TCGA-THCA patients were classified as two categories via a consistent clustering algorithm, and the differential genes between the two categories were subsequently screened. A sex hormone metabolism-related prognostic model (TBSMRPM) of thyroid cancer versus breast cancer consisting of 10 genes was developed by Cox regression analyses and least absolute shrinkage with selection operator (LASSO) cox regression analysis. Finally, we performed clinicopathological subgroup analyses to analyze the correlation between TBSMRPM and clinical characteristics, immune infiltration, tumor mutation burden (TMB), and chemosensitivity, and verified the expression of TBSMRPM signature genes by qRT-PCR.ResultsWe identified 2 clusters correlated with sex hormone metabolism, and screened 10 prognostic differential genes related to thyroid cancer, breast cancer and sex hormone metabolism. After establishing the two risk groups for thyroid cancer originated from TBSMRPM, the results showed that the high-risk group exhibited the shorter DFS (P<0.05). In further clinical stratification analysis, immune infiltration analysis, TMB and drug sensitivity analysis, the two TBSMRPM groups showed significant differences. The qRT-PCR results showed that C2CD4A, CERS1, MMP9, SLC5A1, HORMAD2 were highly expressed in the IHH4, KTC-1, and TPC-1 cell lines, while SLITRK2, ARHGEF37, PLP1, RNF223, and F3 were lowly expressed.ConclusionThe TBSMRPM established in this study has a certain value for the prognosis of thyroid cancer and contributes to refine clinicians’ treatment protocols

Privacy-preserving pathological data sharing among multiple remote parties

The sharing of pathological data is highly important in various applications, such as remote diagnosis, graded diagnosis, illness treatment, and specialist system development. However, ensuring reliable, secure, privacy-preserving, and efficient sharing of pathological data poses significant challenges. This paper presents a novel solution that leverages blockchain technology to ensure reliability in pathological data sharing. Additionally, it employs conditional proxy re-encryption (C-PRE) and public key encryption with equality test technology to control the scope and preserve the privacy of shared data. To assess the practicality of our solution, we implemented a prototype system using Hyperledger Fabric and conducted evaluations with various metrics. We also compared the solution with relevant schemes. The results demonstrate that the proposed solution effectively meets the requirements for pathological data sharing and is practical in production scenarios

Enhanced Performance of Planar Perovskite Solar Cells Using Low-Temperature Solution-Processed Al-Doped SnO\u3csub\u3e2\u3c/sub\u3e as Electron Transport Layers

Lead halide perovskite solar cells (PSCs) appear to be the ideal future candidate for photovoltaic applications owing to the rapid development in recent years. The electron transport layers (ETLs) prepared by low-temperature process are essential for widespread implementation and large-scale commercialization of PSCs. Here, we report an effective approach for producing planar PSCs with Al3+ doped SnO2 ETLs prepared by using a low-temperature solution-processed method. The Al dopant in SnO2 enhanced the charge transport behavior of planar PSCs and increased the current density of the devices, compared with the undoped SnO2 ETLs. Moreover, the enhanced electrical property also improved the fill factors (FF) and power conversion efficiency (PCE) of the solar cells. This study has indicated that the low-temperature solution-processed Al-SnO2 is a promising ETL for commercialization of planar PSCs

Beneficial effects of baicalein on a model of allergic rhinitis

Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. This study assessed the in vivo protective effect of baicalein post-treatment in an ameliorating ovalbumin (OVA)-sensitized AR rat model. Baicalein attenuated histological alterations, aberrant tissue repair and inflammation after OVA-induced AR. Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-α, IL-1β, and IL-6) in both blood and nasal lavage of rats. Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in baicalein-administered rats. Furthermore, baicalein inhibited the expression of STAT3 phosphorylation in the nasal mucosa. In summary, baicalein attenuated OVA-induced AR and inflammation, which suggests it as a promising therapeutic agent for the alleviation of AR-associated inflammation and pathology

Enhanced Crystallinity of Triple-Cation Perovskite Film via Doping NH\u3csub\u3e4\u3c/sub\u3eSCN

The trap-state density in perovskite films largely determines the photovoltaic performance of perovskite solar cells (PSCs). Increasing the crystal grain size in perovskite films is an effective method to reduce the trap-state density. Here, we have added NH4SCN into perovskite precursor solution to obtain perovskite films with an increased crystal grain size. The perovskite with increased crystal grain size shows a much lower trap-state density compared with reference perovskite films, resulting in an improved photovoltaic performance in PSCs. The champion photovoltaic device has achieved a power conversion efficiency of 19.36%. The proposed method may also impact other optoelectronic devices based on perovskite films

Efficient Planar Heterojunction Perovskite Solar Cells with Li-doped Compact TiO\u3csub\u3e2\u3c/sub\u3e Layer

Perovskite solar cells (PSCs) have been developed rapidly in recent time, and efficient planar PSCs are regarded as the most promising alternative to the Si solar cells. In this study, we demonstrated that Li-doping of compact TiO2 can reduce the density of electron traps and increase the conductivity of the electron transport layer (ETL) of PSCs. Due to the improved electronic property of ETL, the Li-doped compact TiO2 based planar heterojunction PSCs exhibit negligible hysteretic J-V behavior. Comparing with the undoped compact TiO2 based PSCs, the power conversion efficiency (PCE) of the Li-doped compact TiO2 film based PSCs is improved from 14.2% to 17.1%. Fabrication of highly efficient planar PSCs provides a pathway for commercialization of PSCs

Identification and characterization of maize microRNAs involved in the very early stage of seed germination

<p>Abstract</p> <p>Background</p> <p>MicroRNAs (miRNAs) are a new class of endogenous small RNAs that play essential regulatory roles in plant growth, development and stress response. Extensive studies of miRNAs have been performed in model plants such as rice, <it>Arabidopsis thaliana </it>and other plants. However, the number of miRNAs discovered in maize is relatively low and little is known about miRNAs involved in the very early stage during seed germination.</p> <p>Results</p> <p>In this study, a small RNA library from maize seed 24 hours after imbibition was sequenced by the Solexa technology. A total of 11,338,273 reads were obtained. 1,047,447 total reads representing 431 unique sRNAs matched to known maize miRNAs. Further analysis confirmed the authenticity of 115 known miRNAs belonging to 24 miRNA families and the discovery of 167 novel miRNAs in maize. Both the known and the novel miRNAs were confirmed by sequencing of a second small RNA library constructed the same way as the one used in the first sequencing. We also found 10 miRNAs that had not been reported in maize, but had been reported in other plant species. All novel sequences had not been earlier described in other plant species. In addition, seven miRNA* sequences were also obtained. Putative targets for 106 novel miRNAs were successfully predicted. Our results indicated that miRNA-mediated gene expression regulation is present in maize imbibed seed.</p> <p>Conclusions</p> <p>This study led to the confirmation of the authenticity of 115 known miRNAs and the discovery of 167 novel miRNAs in maize. Identification of novel miRNAs resulted in significant enrichment of the repertoire of maize miRNAs and provided insights into miRNA regulation of genes expressed in imbibed seed.</p