О возможности использования эффекта П. А. Ребиндера при бурении скважин

Дано объяснение эффекта П. А. Ребиндера при разрушении горных пород, минералов в присутствии жидкостей различной природы с учетом возникающей при разрушении электризации свежих поверхностей растущих трещин. Указана причина невозможности использования эффекта П. А. Ребиндера при бурении скважин

Система наставничества как средство повышения качества жизни и благополучия пожилых людей

В данной статье институт наставничества рассматривается как концепция повышения качества жизни и достижения непрерывного благополучия лиц старшего поколения во многих странах мира. Анализируется система наставничества как ключевого фактора благополучия предприятия. В данной статье рассмотрены основные направления решения данной задачи на предприятия. Приведены примеры компаний в России и за рубежом, в которых внедрена система наставничества

The Union and Médecins Sans Frontières approach to operational research.

Operational research (OR) has become a hot topic at national meetings, international conferences and donor fora. The International Union Against Tuberculosis and Lung Disease (The Union) and Médecins Sans Frontières (MSF) Operational Centre Brussels strongly promote and implement OR with colleagues in low- and middle-income countries. Here we describe how the two organisations define OR, and explain the guiding principles and methodology that underpin the strategy for developing and expanding OR in those countries. We articulate The Union's and MSF's approach to supporting OR, highlighting the main synergies and differences. Then, using the Malawi National Tuberculosis Control Programme as an example, we show how OR can be embedded within tuberculosis control activities, leading to changes in policy and practice at the national level. We discuss the difficult, yet vitally important, issue of capacity building, and share our vision of a new paradigm of product-related training and performance-based OR fellowships as two ways of developing the necessary skills at country level to ensure research is actually performed. Finally, we highlight the need to consider and incorporate into practice the ethical components of OR. This is a key moment to be involved in OR. We are confident that in partnership with interested stakeholders, including the World Health Organization, we can stimulate the implementation of quality, relevant OR as an integral part of health service delivery that in turn will lead to better health for people, particularly for those living in the poorer parts of the world

The selective PI3Kα inhibitor BYL719 as a novel therapeutic option for neuroendocrine tumors: Results from multiple cell line models

Background/Aims The therapeutic options for metastatic neuroendocrine tumors (NETs) are limited. As PI3K signaling is often activated in NETs, we have assessed the effects of selective PI3Kp110α inhibition by the novel agent BYL719 on cell viability, colony formation, apoptosis, cell cycle, signaling pathways, differentiation and secretion in pancreatic (BON-1, QGP-1) and pulmonary (H727) NET cell lines. Methods Cell viability was investigated by WST-1 assay, colony formation by clonogenic assay, apoptosis by caspase3/7 assay, the cell cycle by FACS, cell signaling by Western blot analysis, expression of chromogranin A and somatostatin receptors 1/2/5 by RT-qPCR, and chromogranin A secretion by ELISA. Results BYL719 dose-dependently decreased cell viability and colony formation with the highest sensitivity in BON-1, followed by H727, and lowest sensitivity in QGP-1 cells. BYL719 induced apoptosis and G0/G1 cell cycle arrest associated with increased p27 expression. Western blots showed inhibition of PI3K downstream targets to a varying degree in the different cell lines, but IGF1R activation. The most sensitive BON-1 cells displayed a significant, and H727 cells a non- significant, GSK3 inhibition after BYL719 treatment, but these effects do not appear to be mediated through the IGF1R. In contrast, the most resistant QGP-1 cells showed no GSK3 inhibition, but a modest activation, which would partially counteract the other anti-proliferative effects. Accordingly, BYL719 enhanced neuroendocrine differentiation with the strongest effect in BON-1, followed by H727 cells indicated by induction of chromogranin A and somatostatin receptor 1/2 mRNA-synthesis, but not in QGP-1 cells. In BON-1 and QGP-1 cells, the BYL719/everolimus combination was synergistic through simultaneous AKT/mTORC1 inhibition, and significantly increased somatostatin receptor 2 transcription compared to each drug separately. Conclusion Our results suggest that the agent BYL719 could be a novel therapeutic approach to the treatment of NETs that may sensitize NET cells to somatostatin analogs, and that if there is resistance to its action this may be overcome by combination with everolimus

Heavy and extreme precipitation events in the Sichuan Basin during the 2020 summer season in a set of kilometre-scale simulations

The Sichuan Basin (SB), a lowland region in southwest China located at the eastern slope of the Tibetan Plateau (TP), regularly experiences heavy and extreme precipitation events. These extreme events often lead to flooding that can pose a threat to people’s lives and livelihoods in this densely populated area. A notable example is the summer of 2020, during which large parts of East Asia experienced anomalously high precipitation. In the SB, these events broke the previous record of daily accumulated rainfall at multiple stations. Since such events are expected to increase in both frequency and intensity in a warmer climate, understanding their causes and the physical processes involved is of high relevance in the SB region. Modelling the climate in mountainous regions with complex topography is challenging but recent developments in convection-permitting modelling make it possible to perform process-based studies. The CORDEX Flagship Pilot Study Convection-Permitting Third Pole (CPTP) aims to improve our understanding of the water cycle over the TP and its surrounding regions using a multi-model ensemble of kilometre-scale simulations. Recent results using a set of CPTP simulations for one extreme precipitation event suggest that an accurate representation of the large-scale forcing is crucial to correctly simulate the event. In this study, we assess how well the kilometre-scale CPTP models WRF, ICON-CLM and COSMO-CLM capture multiple observed heavy and extreme precipitation events that occurred in the SB during the summer of 2020 by validating them against observations and reanalysis data. In addition, we investigate how the simulations differ among each other in representing the observed events and related important physical factors, e.g. large- and mesoscale circulation and moisture transport. We find that all model systems fail to reproduce the observed intensity and location of the precipitation events as they either underestimate the intensity or simulate the event in a different location. Our analysis shows that model performance in simulating precipitation depends on their ability to reproduce the jet stream and the transport of water vapour. We conclude that ICON-CLM is most skillful for all analysed events, but there is need for further improvement in convection-permitting modelling in the TP region

Good Looking Pottery Goes to Lunch

Wrought by the magic touch of the potter, colored pottery enhances a tablesetting. It is attractive in its many colors, shapes and designs and adds a distinctive charm of it\u27s own. One of the loveliest of wares is made with Mohabe Desert talc rock as its basic constituent which prevents crazing, chipping or scaling of glaze

Will the Court use \u3ci\u3eDobbs\u3c/i\u3e to Overturn \u3ci\u3eSullivan\u3c/i\u3e? Revisiting the \u3ci\u3eSullivan\u3c/i\u3e Decision in the Age of Digital Media

New York Times Co. v. Sullivan is a landmark Supreme Court decision that significantly expanded protection for the press under the First Amendment by limiting public officials’ ability to sue for defamation. The ruling established the “actual malice” standard, requiring public officials to prove that defamatory statements were made with knowledge of their falsity or with reckless disregard for the truth. In recent years, Justice Thomas has repeatedly criticized Sullivan, arguing that the decision is more a product of judicial policymaking than of constitutional interpretation, with minimal grounding in the text or history of the First or Fourteenth Amendments. Other Justices have also raised concerns about the broad application of the actual malice standard to contexts beyond its original scope, including its extension to individuals who are not public officials. Justice Gorsuch, in particular, has voiced objections rooted in the modern media landscape. He contends that the rise of digital media has dramatically amplified the spread of misinformation, and the actual malice standard, as applied today, hinders efforts to hold individuals accountable for spreading false information. This, Gorsuch argues, undermines the public’s access to reliable information, threatening the democratic process. This Note delves into Justice Gorsuch’s critique, exploring how the digital era has reshaped the public square and examining the role of misinformation on social media in eroding democratic norms. With several Justices expressing concerns about Sullivan, many observers have speculated that the Court’s reference to First Amendment jurisprudence in the Bruen decision signaled an intent to use history and tradition to revisit Sullivan and its progeny. The second part of this Note examines whether the Court is likely to overturn Sullivan by applying the stare decisis factors outlined in Dobbs, the same framework used to overturn Roe and Casey. The third section of this Note evaluates the likelihood that the Court will revisit Sullivan. H.W. Perry identifies three key factors that are likely to influence the Court’s decision to overturn a precedent: (1) whether the case provides a suitable vehicle to advance the Court’s desired doctrinal direction; (2) whether there are enough votes to secure a decision on the merits; and (3) whether the issues with the actual malice standard are significant enough for the Court to feel compelled to overturn Sullivan and its extensions. Notably, the Court’s willingness to revisit Sullivan is unlikely to be deterred by its long-standing precedent, as the Court has recently overturned well-established decisions in areas such as abortion rights, affirmative action, and gun control. This trend underscores the influence of the Court’s conservative majority, which could grow even stronger. Consequently, if the Court were able to secure the votes to overturn Sullivan, the moment to act would likely be now