107 research outputs found

    Clinical spectrum of demyelinating disease of central nervous system and frequency of anti AQP4 and anti MOG among them: one-year single-center retrospective study

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    Background: Inflammatory demyelinating diseases of the central nervous system (CNS) are autoimmune conditions leading to significant neurological disability in adults. Recent classifications include myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD) and neuromyelitis optica spectrum disorder (NMOSD) which pose diagnostic challenges due to overlapping clinical and radiological features. This study aimed to assess the clinical spectrum among adults and children diagnosed with CNS demyelinating diseases and to find the proportion of MOG and/or aquaporin-4 (AQP4) autoantibodies amongst them. Methods: This single-center, retrospective study examined 20 patients diagnosed with CNS demyelinating disorders between March, 2023 and February, 2024. Data pertaining to demographics, disease types, CSF analysis, MRI findings, treatment modalities, and serological profiles for anti-AQP4 and anti-MOG antibodies were collected from hospital records and evaluated. Results: Among 20 patients [median age, 34 years (IQR, 18.75); males (n=10) and females (n=10)], acute transverse myelitis (TM) was the most common demyelinating disorder at onset (60%) followed by optic neuritis (ON) (20%). CSF analysis found elevated protein levels in 53% and pleocytosis in 33% of patients. MRI findings revealed longitudinal extensive involvement in 52% of patients, predominantly affecting the cervical and dorsal spine. Serological testing identified 15% positive for anti-AQP4 and 10% for anti-MOG antibodies. MOG+ patients were significantly younger than AQP4+ patients (mean age 16.5 vs. 36.66 years, p=0.016). Both MOG+ patients were male, with 50% presenting with acute TM and 50% with acute disseminated encephalomyelitis. Among AQP4+ patients, the male-to-female ratio was 1:2, with 66.66% presenting with acute TM and 33.33% with ON. Conclusion: CNS demyelinating disorders primarily affect younger individuals, with TM as the most common initial disorder and extensive spinal involvement in cervical and dorsal regions. Serological testing identified three patients with anti-AQP4 and two with anti-MOG antibodies, providing valuable insights into the clinical spectrum of these disorders through cell-based assays

    A retrospective study of 50 cases of lower limb soft tissue infection and its different modalities of presentation and its management

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    Background: Soft tissue infections are common in everyday practice. They show great variations in their severity. Skin and soft tissue infections are usually preceded by minor traumatic events. Among them soft tissue bacterial infections of lower limbs are more common. Patients having diabetes makes the scenario even worst. Diagnosis, intervention and treatment of these infections are very important. This study aims at understanding the pathology involved for lower limb soft tissue infections, spectrum of organisms and different treatment modalities in various age group and gender.Methods: 50 cases of lower limb soft tissue infections were included in this study. Detailed history, clinical examination, investigations, pre-operative preparation, intraoperative details and post-operative management were included.Results: 94% patients were having history of trauma.88% patients were having history of diabetes. Staphylococcus aureus was the most common (43%) organism cultured from swabs followed by pseudomonas (36%) out of total cases. Minimum stay in hospital was of 4 days to a maximum of 34 days. Most of the patients were managed with regular dressing and debridement.Conclusions: The patients sought treatment only when they had extensive lesions which affect their daily living. Health education regarding foot care forms an integral part of surgical management of lower limb soft tissue infections. Readmissions are mainly due to inadequate local control or fluctuating blood sugar levels and improper foot care due to illiteracy, poverty, ignorance and lack of adequate primary care facilities

    Advanced Scoliosis Impact on COPD: Worsened Outcomes Due to Lack of Motivational Interviewing and Shared Decision Making - A Case Report

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    The case presented describes an advanced COPD patient with a history of progressive scoliotic curvature who presented multiple times with complaints of worsening respiratory symptoms. Thus, it is important to emphasize how the lack of meaningful patient communication and patient participation in the plan of care can lead to increased symptoms of anxiety, declining quality of life, and unnecessary medical testing. In addition, the case explores how applying a holistic combination of strategies including motivational interviewing, shared-decision making and proper communication can improve the level of patient care

    Sustainable housing : looking at social and cultural aspects of traditional Indian settlement

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    RESEARCH QUESTION: How social and cultural housing issues can be addressed through the traditional practice of Indian settlement? ABSTRACT: This research aims to strategize a comprehensive design, establishing a link between the traditional and current practice of housing. The intent is to provide the various housing issues; energy waste, social-cultural aspects, ignored the specific need of environment and local people, missing regional architecture characteristics. Social and environmental factors in the housing sectors have been affected by the forces of globalization during the rapid urbanization. In the last three decades, housing construction tends to reflect the requirements of the global market instead of local architecture or social demands. The concept of regional housing is selected as a stepping stone of this research project to provide guidelines for the current housing practice. Hence, the research question: “How social and environmental issues can be addressed through the traditional practice of Indian settlement?” Every year, mass migration has created a shortage of housing. However, modern rapid housing construction has given a roof to migrants at the cost of losing the local identity and characteristic of the city. A large number of migrants comes from the north of Gujarat villages or small towns, who are still rooted in their culture and believes. It is a crucial necessity to understand their lifestyle, needs, and provide good living ambience for the betterment of life and maintain the identity of the local architecture. As per the current scenario, the findings indicate that Ahmedabad, Gujarat is the first Heritage city of India declared by UNESCO. Belonging from Gujarat and having deep connections to Ahmedabad city, because of its rich heritage and culture, the observation of the city raised the need to reidentify the housing practice in the city with the social and environmental value of local heritage architecture. Design methodology incorporates the comparative investigation of spatial form in traditional and current housing practice. It might provide some useful insights providing different type of activities and environment requirements, to develop a typical housing model which will hold the local architectural identity for the local people. Regional housing is a relatively new approach which will consider different factors in the design process, such as location, climate, accessibility, people, construction techniques, and the vernacular environmental approach. Few planned and successful housing projects, provide the inferences to develop the best possible strategy for this approach
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