A Study On Evaluation Of Hair Growth And Grey Hair Effect Of Poly Herbal Oil Formulation On Wistar Albino Rats

Hair has cosmetologically and sociological importance through out the life inframing the beauty and personality of an individual. Hair loss and hair graying at young age are recognized as a sign complex regulation of melanogenesis. Hair loss scientifically termed as alopecia and hair graying scientifically termed as canities. Now a days attention to herbal preparations have enormously increased due to least or zero side effects with desired results. In the present work selected herbs were used to study the effect of hair growth and the greying effect of hair. Cocus Nucifera oil is used as base oil along with Moringa olifera leaves, Psidium guajava leaves, Carica papaya leaves, Trigonella foenumgraecum seeds, Allium cepa bulb, and Nigella sativa seed oil. The Salvia Rosmarinus oil is used as essential oil. The herbal oil was prepared by using different methods and concentrations. The prepared formulations are tested by different evaluating methods, and the hair growth, skin irritation, hair length and grey hair test was done by using four sets of wistar rats. The effective hair growth was observed from day 2 and complete hair growth was recorded by 20 days after using of prepared hair oil applying topically on shaved wistar rats and grey hair effect was tested by using sheep wool fibers. &nbsp

COMPARATIVE PHARMACOGNOSTICAL AND PHYTOCHEMICAL STUDY OF VARIOUS SPECIES OF THE CONTROVERSIAL DRUG ‘PUNARNAVA'

Objective: Punarnava is a controversial drug i.e. its true botanical identity has not been ascertained, and several different species are used as Punarnava. It is a part of many medicinally important traditional formulations. Ayurvedic Pharmacopoeia of India describes three different species–Roots of Boerhaavia diffusa, Trianthema portulacastrum and Boerhaavia verticillata. The present work deals with the microscopic, macroscopic and phytochemical comparison of the roots of these species of Punarnava, so as to differentiate them and establish their quality parameters.Methods: Roots of these three species were collected, and their comparative morphological, microscopical (transverse section, powder study) and the phytochemical (screening, tannin estimation) study was performed.Results: Roots of Boerhaavia diffusa showed morphological characteristics which clearly distinguished it from the other species. They showed the presence of well developed and stratified cork, abnormal vascular bundles which were discontinuous, and a central cavity, presumably formed due to the disintegration of tissues. Boerhaavia verticillata showed the presence of xylem bundles arranged in the form of a ‘X'-shaped cross in the central region. Thick-walled cork cells and pitted xylem vessels were present only in Boerhaavia diffusa root powder, whereas bundles of fibrovascular tissue were present only in the powder of Boerhaavia verticillata. Tannin content was found to be highest in Boerhaavia diffusa roots.Conclusion: The present investigation will help herbal industries and traditional medicinal practitioners to detect adulteration of the medicinally important immunomodulator Boerhaavia diffusa by Trianthema portulacastrum and Boerhaavia verticillata, which are considered to have no immunomodulatory activity.Â

The phytochemical screening, total cucurbitacin content, and in vitro anti-breast cancer activity of Leucopaxillus gentianeus mushroom

Abstract Background The popular Leucopaxillus gentianeus mushroom contains very high nutrients and bioactive compounds with good anti-breast cancer activity. The til oil extract seems to be the most active in preparation. This study aims to find the best extract using different solvents for extraction, to measure the total cucurbitacin content and anti-breast cancer activity in vitro of til oil extract of leucopaxillus gentianeus. Result The dry mushroom material was extracted using continuous hot extraction with til oil, petroleum ether, ethyl acetate, chloroform, methanol, and water of leucopaxillus gentianeus which were used for phytochemical analysis, HPLC method was used for no of phytochemical and anti-breast cancer activity in vitro. The total cucurbitacin content was found based on the HPTLC method. The anti-breast cancer activity was carried out using progesterone and estrogen activity. The number of pecks found during HPLC it is indicated that the list of phytochemical presents in a different extract, also good yield found with til oil extract was 6.8 gm. Progesterone and estrogen inhibited high with til oil extract and cucurbitacin content was found to be 264.00 ng. Conclusion The significance of the biotherapeutic effects increases with the number of bioactive components in the preparation. Leucopaxillus gentianeus til oil extract has high cucurbitacin content and strong anti-breast cancer properties. Graphical abstrac

A Review on Some Indian Medicinal Plants useful in Hair Care

Abstract: Hair related problems are an ever-increasing problem. Compared with chemical herbal ingredients are more preferred because of their easy availability and lesser side effects. The utilization of novel medicinal plant ingredients in various formulations such as hair tonic, hair gels, hair oils and hair dyes has proved to be beneficial than the formulations containing chemical components. These novel ingredients have helped in the enhancement of the beauty of hair and help in the treatment of various hair problems such as dandruff, alopecia and many more. It is a universal problem affecting both sexes. Herbal cosmetics are now appropriate solution to the current problem. This review describes the use of some natural medicinal plants for hair growth promotion, Anti-hair fall and Anti-grey hair with a brief description of the major use, plant parts used and the active compounds responsible for the use of the herbal plants. </jats:sec

Cucurbitacins: Nature’s Wonder Molecules

Abstract: Over the past decades, several natural constituents belonging to different classes have been isolated from plants for medicinal purposes. Cucurbitacins is one such type of natural compound. Cucurbitacin is a class of biochemical compounds that some plants, notably members of the pumpkin and gourd family, Cucurbitaceae produce and function as a defense against herbivores. They and their derivatives have been found in many plant families (including Brassicaceae, Cucurbitaceae, Scrophulariaceae, Begoniaceae, Elaeocarpaceae, Datiscaceae, Desfontainiaceae, Polemoniaceae, Primulaceae, Rubiaceae, Sterculiaceae, Rosaceae, and Thymelaeaceae), in some mushrooms (including Russula and Hebeloma) and even in some marine mollusks. They have been isolated from various plant species, chiefly belonging to the Cucurbitaceae family, which comprises around 130 genera and 800 species. Cucurbitacins are a group of tetracyclic triterpenoid substances that are highly oxygenated and contain a cucurbitane skeleton characterized by 9β-methyl−19-norlanosta- 5-ene. Cucurbitacins can be categorized into twelve main groups according to variations in their side-chains. Cucurbitacins A, B, C, D, E, F, I, J, K, L, O, P, Q, R, S, and their glycosides are mainly found in Cucurbitaceae family members. These plants have been used as folk medicines in some countries because of their broad spectrum of crucial pharmacological activities such as anti- inflammatory, anti-cancer, anti-diabetic, and anti-atherosclerotic effects. The present review explores the possibility of a correlation between the chemistry of various Cucurbitacins and the uses of the plants which contain them, thereby opening avenues for further phytochemical, ethnomedicinal, and modern pharmacological research on these important molecules. </jats:sec

Tackling COVID-19 Through Ayurveda: A Review on the Herbs of Recommended Indian Remedies

: COVID-19 has rapidly spread across the globe and has been declared a pandemic. Presently, drugs or vaccines are unavailable, and patients are treated on symptom management basis. Traditional healthcare can contribute to prevent the infection in healthy individuals as well as in the treatment of infected patients. Ayurveda medicines become even more relevant as there is a descriptive illustration of causation and management of diseases similar to COVID-19 as Janapadodhwamsa. Meanwhile, Ministry of AYUSH, Govt. of India has recommended herbal remedies for prevention of COVID-19 infection. The remedies include 1. Herbal tea twice a day and 2. Golden milk for immunity boosting measures. Further, Steam inhalation and medicated honey is recommended for sore throat. In this review, we have tried to evaluate effectiveness of the recommended Indian remedies in prevention and treatment of COVID-19 conditions with available scientific literature. COVID-19, being primarily a respiratory disease, all 9 herbs of remedies have been selected for analysing their respiratory diseases related immunomodulatory and other activities, anti-viral, antibacterial activities as well as in silico effectiveness of constituents thereof against SARS-CoV-2 targets. The literature search was carried out in electronic databases namely PubMed, ScienceDirect, ACS Publications, Clinicaltrials.gov, Springer, and Google Scholar. The scientific evaluation revealed that the recommended Indian remedies might be useful in tackling COVID-19 situation, though scientific interventional studies are required to establish the claims. </jats:sec