1,567 research outputs found

    Damages for Mental Suffering Resulting from Mistreatment of a Cadaver

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    Syftet med studien är att studera hur cheferna upplever och arbetar med kompetensbaserad rekrytering samt i vilken utsträckning de upplever att de uppnått förväntat resultat. Vi har analyserat en kompetensbaserad rekryteringsmodell (KBR-modell) utifrån två teoretiska perspektiv på organisationen; det humanistiska och det strukturella, samt studerat spänningen dem emellan rörande det standardiserade rekryteringssystemet. Kvalitativa, semistrukturerade intervjuer har använts vid vår empiriinsamling. Slutsatserna visar att cheferna upplever kombinationen KBR-modellen och stödet från HR-konsulterna på ett tillfredsställande sätt eftersom KBR-modellen underlättar rekryteringsarbetet, men att de ändå upplever att de har tillräckligt med handlingsutrymme. Samtliga upplever att de uppnått det önskade resultatet "rätt man på rätt plats" genom en kombination av stöd från HR-konsulten och användning av KBR-modellen. Organisationen kombinerar bra rutiner vid rekryteringen med ett systematiskt verktyg och HR-funktion, samt en kombination av de humanistiska och strukturella perspektiven. Slutligen är det rimligt att anta att främst det strukturella perspektivet speglas i organisationens rekryteringsarbete

    NFV Orchestrator Placement for Geo-Distributed Systems

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    The European Telecommunications Standards Institute (ETSI) developed Network Functions Virtualization (NFV) Management and Orchestration (MANO) framework. Within that framework, NFV orchestrator (NFVO) and Virtualized Network Function (VNF) Manager (VNFM) functional blocks are responsible for managing the lifecycle of network services and their associated VNFs. However, they face significant scalability and performance challenges in large-scale and geo-distributed NFV systems. Their number and location have major implications for the number of VNFs that can be accommodated and also for the overall system performance. NFVO and VNFM placement is therefore a key challenge due to its potential impact on the system scalability and performance. In this paper, we address the placement of NFVO and VNFM in large-scale and geo-distributed NFV infrastructure. We provide an integer linear programming formulation of the problem and propose a two-step placement algorithm to solve it. We also conduct a set of experiments to evaluate the proposed algorithm.Comment: This paper has been accepted for presentation in 16th IEEE International Symposium on Network Computing and Applications (IEEE NCA 2017

    A Virtual Network PaaS for 3GPP 4G and Beyond Core Network Services

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    Cloud computing and Network Function Virtualization (NFV) are emerging as key technologies to overcome the challenges facing 4G and beyond mobile systems. Over the last few years, Platform-as-a-Service (PaaS) has gained momentum and has become more widely adopted throughout IT enterprises. It simplifies the applications provisioning and accelerates time-to-market while lowering costs. Telco can leverage the same model to provision the 4G and beyond core network services using NFV technology. However, many challenges have to be addressed, mainly due to the specificities of network services. This paper proposes an architecture for a Virtual Network Platform-as-a-Service (VNPaaS) to provision 3GPP 4G and beyond core network services in a distributed environment. As an illustrative use case, the proposed architecture is employed to provision the 3GPP Home Subscriber Server (HSS) as-a-Service (HSSaaS). The HSSaaS is built from Virtualized Network Functions (VNFs) resulting from a novel decomposition of HSS. A prototype is implemented and early measurements are made.Comment: 7 pages, 6 figures, 2 tables, 5th IEEE International Conference on Cloud Networking (IEEE CloudNet 2016

    Na2.9KMo12S14: a novel quaternary reduced molybdenum sulfide containing Mo12clusters with a channel structure

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    International audienceThe crystal structure of trisodium potassium dodecamolybdenum tetradecasulfide, Na2.9 (2)KMo12S14, consists of Mo12S14S6 cluster units interconnected through interunit Mo-S bonds and delimiting channels in which the Na+ cations are disordered. The cluster units are centered at Wyckoff positions 2d and have point-group symmetry 3.2. The K atom lies on sites with 3.2 symmetry (Wyckoff site 2c) between two consecutive Mo12S14S6 units. One of the three independent S atoms and one Na atom lie on sites with 3.. symmetry (Wyckoff sites 4e and 4f). The other Na atom occupies a 2b position with -3.. symmetry. The crystal studied was a merohedral twin with refined components of 0.4951 (13) and 0.5049 (13)

    Na4.25Mo15S19: a novel ternary reduced molybdenum sulfide containing Mo6 and Mo9 clusters

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    International audienceThe structure of tetra-sodium penta-deca-molybdenum nona-deca-sulfide, Na4.25Mo15S19, is isotypic with Na3.9Mo15Se19 [Salloum et al. (2013 ). Acta Cryst. E69, i67-i68]. It is characterized by Mo6S (i) 8S (a) 6 and Mo9S (i) 11S (a) 6 (where i represents inner and a apical atoms) cluster units that are present in a 1:1 ratio. The cluster units are centered at Wyckoff positions 2b and 2c, and have point-group symmetry -3 and -6, respectively. The clusters are inter-connected through additional Mo-S bonds. The Na(+) cations occupy inter-unit voids formed by six or seven S atoms. One Mo, one S and one Na site [occupancy 0.751 (12)] are situated on mirror planes, and two other S atoms and one Na site (full occupancy) are situated on threefold rotation axes

    Preclinical Analysis of JAA-F11, a Specific Anti-Thomsen-Friedenreich Antibody via Immunohistochemistry and In Vivo Imaging.

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    The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked), has been comprehensively studied by in vitro immunohistochemical (IHC) staining of human tumor and normal tissue microarrays and in vivo biodistribution and imaging by micro-positron emission tomography imaging in breast and lung tumor models in mice. The IHC analysis detailed herein is the comprehensive biological analysis of the tumor specificity of JAA-F11 antibody performed as JAA-F11 is progressing towards preclinical safety testing and clinical trials. Wide tumor reactivity of JAA-F11, relative to the matched mouse IgG3 (control), was observed in 85% of 1269 cases of breast, lung, prostate, colon, bladder, and ovarian cancer. Staining on tissues from breast cancer cases was similar regardless of hormonal or Her2 status, and this is particularly important in finding a target on the currently untargetable triple-negative breast cancer subtype. Humanization of JAA-F11 was recently carried out as explained in a companion paper "Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and In Vitro Efficacy Analysis" (Neoplasia 19: 716-733, 2017), and it was confirmed that humanization did not affect chemical specificity. IHC studies with humanized JAA-F11 showed similar binding to human breast tumor tissues. In vivo imaging and biodistribution studies in a mouse syngeneic breast cancer model and in a mouse-human xenograft lung cancer model with humanized 124I- JAA-F11 construct confirmed in vitro tumor reactivity and specificity. In conclusion, the tumor reactivity of JAA-F11 supports the continued development of JAA-F11 as a targeted cancer therapeutic for multiple cancers, including those with unmet need
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