Making music in the radio theater when creating a spatial sound picture

When creating a spatial sound picture in the radiotheater, the music is also fully involved. It can be composed especially for the production or it may be present as a musical arrangement from excerpts or entire musical works. With the help of the music, the artistic and aesthetic radio dramatic built and certain dramatic moments are reinforced

Spatial Scaling for the Numerical Approximation of Problems on Unbounded Domains

In this dissertation we describe a coordinate scaling technique for the numerical approximation of solutions to certain problems posed on unbounded domains in two and three dimensions. This technique amounts to introducing variable coefficients into the problem, which results in defining a solution coinciding with the solution to the original problem inside a bounded domain of interest and rapidly decaying outside of it. The decay of the solution to the modified problem allows us to truncate the problem to a bounded domain and subsequently solve the finite element approximation problem on a finite domain. The particular problems that we consider are exterior problems for the Laplace equation and the time-harmonic acoustic and elastic wave scattering problems. We introduce a real scaling change of variables for the Laplace equation and experimentally compare its performance to the performance of the existing alternative approaches for the numerical approximation of this problem. Proceeding from the real scaling transformation, we introduce a version of the perfectly matched layer (PML) absorbing boundary as a complex coordinate shift and apply it to the exterior Helmholtz (acoustic scattering) equation. We outline the analysis of the continuous PML problem, discuss the implementation of a numerical method for its approximation and present computational results illustrating its efficiency. We then discuss in detail the analysis of the elastic wave PML problem and its numerical discretiazation. We show that the continuous problem is well-posed for sufficiently large truncation domain, and the discrete problem is well-posed on the truncated domain for a sufficiently small PML damping parameter. We discuss ways of avoiding the latter restriction. Finally, we consider a new non-spherical scaling for the Laplace and Helmholtz equation. We present computational results with such scalings and conduct numerical experiments coupling real scaling with PML as means to increase the efficiency of the PML techniques, even if the damping parameters are small

Study on the red-leaf hybrid no. 9-205 as a rootstock for peach and nectarine cultivars

The aim of the present study was to establish the growth characteristics of the red-leaf peach hybrid No. 9-205, grown in a nursery, targeting its submission in future for recognition as a new vegetative rootstock for peach and nectarine cultivars. The traditional seedling rootstock 'Elberta' and the vegetative one GF-677 were included in the study. Hybrid No. 9-205 was selected from a population obtained at the Fruit- Growing Institute in Plovdiv by open pollination of Rutgers Red Leaf seedling rootstock for peach, used in the past. It is characterized by high drought resistance and good resistance to diseases and pests. It is easily propagated under in vitro conditions and shows weaker growth compared to GF-677 rootstock. 18 cultivar/rootstock combinations were studied, including two cultivars of each peach type: for fresh consumption, for processing and of the nectarine type. 'Laskava' cultivar for fresh consumption, the processing cultivar 'Spasena' and the cultivar 'Gergana', which is of the nectarine type, are newly established in result of the implementation of the breeding programme at the Fruit-Growing Institute - Plovdiv. They were officially recognized in the period 2009- 2012. The percentage of survival and of grafted bud shooting is high enough and meets the requirements of the production practices in nurseries. The planting material of the vegetative rootstock No. 9-205 is uniform in plant height and stem width and it fully complies with the quality standards

Late Diagnosis of Urinary Peritonitis Due to a Lesion of the Left Ureter During Laparoscopic Anterior Resection of the Rectum—Laparoscopic Solution. Clinical Case and Literature Review

Ureteral lesions are a rare complication of colorectal surgery. This type of surgical procedure is the second most common cause of such complications, second only to gynecological operations, which account for around 50%. According to the localization of the lesion, they аre grouped into three types: injury to the proximal, middle, and distal part of the ureter, with the latter being the most common—around 80–90%. Most of the lesions are not recognized intraoperatively and sometimes the diagnosis can be delayed significantly. The time of diagnosis and the localization of the injury are crucial to the choice of treatment. We present a case of a patient, with a late diagnosis of lesion of the left ureter after the laparoscopic anterior resection of the rectum, which was treated with a laparoscopic uretero-ureteral anastomosis with simultaneous double-J catheterization. We also present a short literature review on the subject

Effects of Psychopathy on Neurocognitive Domains of Impulsivity in Abstinent Opiate and Stimulant Users

Background: Psychopathy and substance use disorders (SUDs) are both characterized by neurocognitive impairments reflecting higher levels of impulsivity such as reward-driven decision-making and deficient inhibitory control. Previous studies suggest that psychopathy may exacerbate decision-making deficits, but it may be unrelated to other neurocognitive impairments among substance dependent individuals (SDIs). The aim of the present study was to examine the role of psychopathy and its interpersonal-affective and impulsive-antisocial dimensions in moderating the relationships between dependence on different classes of drugs and neurocognitive domains of impulsivity.Method: We tested 693 participants (112 heroin mono-dependent individuals, 71 heroin polysubstance dependent individuals, 115 amphetamine mono-dependent individuals, 76 amphetamine polysubstance dependent individuals, and 319 non-substance dependent control individuals). Participants were administered the Psychopathy Checklist: Screening Version (PCL:SV) and seven neurocognitive tasks measuring impulsive choice/decision-making (Iowa Gambling Task; Cambridge Gambling Task; Kirby Delay Discounting Task; Balloon Analog Risk Task), and impulsive action/response inhibition (Go/No-Go Task, Immediate Memory Task, and Stop Signal Task).Results: A series of hierarchical multiple regressions revealed that the interpersonal-affective dimension of psychopathy moderated the association between decision-making, response inhibition and both amphetamine and heroin dependence, albeit differently. For amphetamine users, low levels of interpersonal-affective traits predicted poor decision-making on the Iowa Gambling Task and better response inhibition on the Stop Signal task. In contrast, in heroin users high interpersonal-affective psychopathy traits predicted lower risk taking on the Cambridge Gambling Task and better response inhibition on the Go/No-Go task. The impulsive-antisocial dimension of psychopathy predicted poor response inhibition in both amphetamine and heroin users.Conclusions: Our findings reveal that psychopathy and its dimensions had both common and unique effects on neurocognitive function in heroin and amphetamine dependent individuals. Our results suggest that the specific interactions between psychopathy dimensions and dependence on different classes of drugs may lead to either deficient or superior decision-making and response inhibition performance in SDIs, suggesting that psychopathy may paradoxically play a protective role for some neurocognitive functions in specific subtypes of substance users

Validation of the Substance Use Risk Profile Scale (SURPS) With Bulgarian Substance Dependent Individuals

Background: The Substance Use Risk Profile Scale (SURPS) is a 23-item self-report questionnaire that assesses four well-validated personality risk factors for substance misuse (Impulsivity, Sensation Seeking, Anxiety Sensitivity, and Hopelessness). While the SURPS has been used extensively with adolescents at risk for substance dependence, its properties with adult substance-dependent populations have been understudied. Further, the validity of the Bulgarian version of the SURPS has not been evaluated. The aims of the present study were to examine the factor structure of the Bulgarian version of the SURPS, its psychometric properties, and its ability to distinguish individuals with substance dependence from healthy controls.Methods: Participants included 238 individuals ages 18 to 50 (45% female): 36 “pure” (i.e., mono-substance dependent) heroin users, 34 “pure” amphetamine users, 32 polysubstance users, 64 controls with no history of substance dependence, 43 unaffected siblings of heroin users, and 29 unaffected siblings of amphetamine users. We explored the factor structure of the Bulgarian version of the SURPS with confirmatory factor analyses, examined its reliability and validity, and tested for group differences between substance dependent and non-dependent groups.Results: Confirmatory factor analyses (CFA) replicated the original four-factor model of the SURPS. The four subscales of the SURPS demonstrated good internal consistency (Cronbach's alphas ranged from 0.71 to 0.85) and adequate concurrent validity. Significant group differences were found on the Impulsivity and Sensation Seeking subscales, with the three substance dependent groups scoring higher than controls.Conclusions: The SURPS is a valid instrument for measuring personality risk for substance use disorders in the Bulgarian population. The Bulgarian version of the SURPS demonstrates adequate to good reliability, concurrent validity, and predictive validity. Its ability to distinguish between groups with and without a history of substance dependence was specific to externalizing traits such as Impulsivity and Sensation Seeking, on which opiate, stimulant, and polysubstance dependent individuals scored higher than non-dependent controls

Обезвреднување на трудот - Анализа на трудово-правната легислатива во периодот на транзицијата

Обично, кога станува збор за незадоволителната состојба со работничките права во Република Македонија се мисли на тоа дека не се почитуваат правата што на работниците им ги гарантира законот. Односно, дека главниот проблем со работничките права е нивното кршење. Како што може да покаже секое теренско истражување, кршењето на работничките права е сериозен проблем кој значително го влошува животниот стандард и човечкото достоинство на работниците во РМ. Но, положбата на работниците немаше да биде толку лоша ако само ова беше проблем. Далеку помалку воочлив проблем, кој е барем исто сериозен колку и кршењето на правата, е нивното постојано намалување. За намалување или кратење на работничките права зборуваме кога преку донесување на нова законска регулатива (измени и дополнувања на постоечки закон или изгласување нов закон) доаѓа до намалување на правата кои законот им ги дава на работниците. Наспроти тоа, кршењето или непочитувањето на работничките права подразбира оневозможување работниците да ги уживаат оние права што се пропишани во законот. И додека и кај самите работници и кај пошироката јавност има јасно изградена свест дека работничките права константно се кршат, тоа е далеку од точно во поглед на намалувањето на работничките права. Со намера да се покаже дека и намалувањето на работничките права е доста сериозен проблем, пристапено беше кон истражување на законската регулатива што се однесува на работничките права во РМ. Целта на ова истражување е да покаже дека станува збор за смислен неолибералистички процес на намалување на правата, односно дека не се работи за изолирани случаи на намалувања. Исто така, интенцијата беше да се одбегне позитивистичкиот пристап и - преку компаративно-правен метод - да се докаже дека континуирано, без разлика која политичка партија е на власт, се носени негативни промени во законската регулатива на штета на работничките права

Анализа на трудово-правната легислатива во периодот на транзицијата - Најважни теоретски сознанија

Во врска со присутните процеси на перманентно и систематско кршење и намалување на работничките права, вреди да се каже дека кај нас овие две негативни појави не се со ѕид одвоени една од друга: всушност, губењето на одредено работничко право во Република Македонија се случува токму на таков начин што неговото неуживање, преку усвојувањето на соодветна законска регулатива, престанува да биде „кршење“ и станува „намалување“ на правата!? Саркастично, но еден од начините на надминување на дискрепанцата помеѓу законски даденото право и фактичкото кршење на тоа право доста често се надминувала или барем се намалувала преку усвојување промени во законската регулатива кои резултираат со намалување на правата на работниците! На тој начин, оневозможеноста работникот да остварува одредено право перфидно се трансформира од „кршење на законските одредби“ во „постапување согласно законот“!? Работничките права во Македонија беа и ќе бидат на удар, многу повеќе ако самите работници и политичките субјекти кои ги застапуваат нивните интереси не застанат во нивна бескомпромисна одбрана. Сè додека не е така, и понатаму ќе се намалуваат и кршат правата, а студиите од овој тип, за жал, ќе имаат неисцрпен материјал..

Synthesis of isoprenyl diphosphate surrogates as potential inhibitors of prenyl converting enzymes

Der Schwerpunkt dieser Arbeit war es, eine Bibliothek von synthetischen Verbindungen zu erzeugen, die potentiell als chemische Nachahmung der in reichlichen Mengen natürlich vorkommenden Isoprenyldiphosphatsubstrate von 3,3-Dimethylallyldiphosphat (DMAPP), Geranyldiphosphat (GPP) und Farnesyldiphosphat mit besonderer Beachtung der geladenen Diphosphat-Gruppe dienen können. Im Gegensatz zu den intensiv untersuchten Diphosphat-Analoga in der Literatur, die in erster Linie auf phosphorhaltigen Säuren basieren, wird in der vorliegenden Arbeit eher die synthetische Erschließung von nur Kohlenstoff- und Sauerstoff enthaltenden Substraten, beispielsweise auf Carbonsäuren basierter Diphosphat-Ersatz, versucht. Einige außergewöhnlich bioaktive Naturstoffe (z.B. Chaetomellic Säure und Saragossasäure) verfügen über einen Polycarbonsäure-Kern, der die Diphosphat-Gruppe von natürlichen Substraten nachahmt und für die effiziente Hemmung bestimmter prenylierender Enzyme verantwortlich ist. Von der Vielfalt in der Natur angeregt, wurde eine ganze Reihe von verschiedenen Mono-, Di-, Tri-, und Tetracarbonsäuren dargestellt, die eine Isoprenylkette unterschiedlicher Größe (C5, C10, C15) enthalten und durch Massenspektrometrie, NMR-Spektroskopie und chromatographische Techniken charakterisiert. Mehr als die Hälfte der in dieser Arbeit vorgestellten Verbindungen wurden vorher noch nicht beschrieben oder registriert. Somit können ihre Strukturen als völlig neu bezeichnet werden, und ihre Auswirkungen auf biologische Targets, insbesondere auf prenylierende Enzyme, muss noch untersucht werden.The main focus of this work was to generate a library of synthetic compounds which are supposed to function as chemical mimicries of the naturally abundant isoprenyl diphosphate substrates 3,3-dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP) and farnesyl diphosphate (FPP) with a special emphasis on the charged diphosphate group. In contrast to the extensively studied diphosphate analogues in the literature which are primarily based on phosphorus containing acids, the present work rather attempts the synthetic exploitation of substrates based on carbon and oxygen alone, i.e. diphosphate surrogates based on carboxylic acids. Some exceptionally bioactive natural products (e.g. chaetomellic acid and zaragozic acid) feature a polycarboxylic acid core that mimics the diphosphate group of natural substrates and which is responsible for an efficient inhibition of particular prenylation-processing enzymes. Being inspired by Nature´s diversity, a whole series of various mono-, di-, tri- and tetra-carboxylic acids bearing an isoprenyl chain of different size (C5, C10, C15) have been synthesized and characterized by means of mass spectrometric, NMR spectroscopic and chromatographic techniques. More than half of the compounds presented in this thesis have not been published or registered previously. Thus, their structures can be denoted as completely new, and their impact on biological targets, especially prenylating enzymes, still remains to be evaluated.von Dimitar Vasile