On the Discovery of Success Trajectories of Authors

Understanding the qualitative patterns of research endeavor of scientific authors in terms of publication count and their impact (citation) is important in order to quantify success trajectories. Here, we examine the career profile of authors in computer science and physics domains and discover at least six different success trajectories in terms of normalized citation count in longitudinal scale. Initial observations of individual trajectories lead us to characterize the authors in each category. We further leverage this trajectory information to build a two-stage stratification model to predict future success of an author at the early stage of her career. Our model outperforms the baseline with an average improvement of 15.68% for both the datasets.Comment: 2 pages, 1 figure in 25rd International World Wide Web Conference WWW 201

IDENTIFICATION OF POTENTIAL SALMONELLA TYPHI BETA-LACTAMASE TEM 1 INHIBITORS USING PEPTIDOMIMETICS, VIRTUAL SCREENING, AND MOLECULAR DYNAMICS SIMULATIONS

Objective: The purpose of this study was to identify a potential peptidomimetic S. typhi Beta-lactamase TEM 1 inhibitor to tackle the antibiotic resistance among S. typhi.Methods: The potential peptidomimetic inhibitor was identified by in silico docking of the small peptide WFRKQLKW with S. typhi Beta-lactamase TEM 1. The 3D coordinate geometry of the residues of small peptide interacting with the active site of the receptor was generated and mimics were identified using PEP: MMs: MIMIC server. All the identified mimics were docked at the active site of the receptor using Autodock 4.2 and the best-docked complex was selected on the basis of binding energy and number of H-bonds. The complex was then subjected to molecular dynamics simulations of 30 ns using AMBER 12 software package. The stereochemical stability of the Beta-lactamase TEM 1-WFRKQLKW complex was estimated with the help of Ramachandran plot using PROCHECK tool.Results: In the present study, a new potential peptidomimetic inhibitor (ZINC05839264) of Beta-lactamase TEM 1 has been identified based on antimicrobial peptide WFRKQLKW by virtual screening of the MMsINC database. The docking and molecular simulation studies revealed that the mimic binds more tightly to the active site of the receptor than the peptide. The Ramachandran plot also shows that the Beta-lactamase TEM 1-mimic complex is stereo chemically more stable than Beta-lactamase TEM 1-WFRKQLKW complex as more number of residues (93.6%) are falling under the core region of the plot in case of the former.Conclusion: The study shows that the peptidomimetic compound can act as a potential inhibitor of S. typhi Beta-lactamase TEM 1 and further it can be developed into more effective therapeutic to tackle the problem of antibiotic resistance

PULSAR DETECTION SYSTEM USING RADIO TELESCOPE

Radio astronomers and Researchers have detected numerous neutron stars in our galaxy, and they also predicted the Existence of many more neutron stars in space. Pulsars are very peculiar, yet almost inscrutable celestial objects. This is an object which is impelling radiation into space closest to the speed of light. Neutron stars are the most interesting galactic bodies to mankind. The things that hold us during the whole study are the fascinating properties of pulsar i.e. high density, a small diameter, strong gravity, and strong magnetic field. As the peculiar properties and the extreme nature of pulsar continue to disclose this catches the attention of Astronomers. Pulsars are distant objects. So, it is very tedious job to capture the radiations coming from it for this we have designed a system which consist of an Antenna, Filters, Amplifiers and Receiver. The signal we capture through the antenna will undergo signal processing to extract the Pulse which is buried in noise. The techniques used here are the fast-folding algorithm (FFA) and Fast Fourier transform (FFT) are explained along. By this whole study to building a system and performed signal processing and obtained the Pulse

AYURVEDIC MANAGEMENT OF SHWITRA (VITILIGO)- A CASE STUDY.

The Sanskrit term Shweta, which meaning "white patch," is the root of the name Shwitra. Shwitra (Vitiligo) is a condition that is referenced in the classic Kushta Roga Chikitsa and affects a significant section of the pediatric population as a result of poor dietary and lifestyle choices. Shwitra "Shweta Bhava Michanti Shwitram" is what the Kashyapa Samhita says. Kilasa, Daruna, Aruna, and Shweta Kushta are some more names for it. In contemporary medicine, vitiligo is referred to as an auto immune illness and manifests as a white patch on the skin. A widespread, progressive, chronic skin illness called vitiligo is characterized by patches of skin with sharp, frequently hyperpigmented edges caused by a lack of melanin pigments. Approximately 1% of people worldwide suffer from this illness. This condition is included under the general topic of Shwitra in Ayurveda. Every Acharya has the same opinion that the two primary therapeutic modalities mentioned in the classics—Samshodhan Karma and Samshaman Karma—should be used to treat Shwitra or Kushtha first. In their various Samhitas, Acharyas have specified a variety of internal and external uses, as well as sun exposure, for Shaman Chikitsa in the Shwitra Roga. Samhitas discuss a wide range of single and combination medications; among them, Shwitrahar Kashaya and lepa are mentioned in detail. One of them is chosen and shown to be useful for the investigation

Ex situ conservation and qualitative characterization of traditional cultivars of rice (Oryza sativa L.)

168-179Genetic diversity of rice cultivars offers adequate opportunity for added advantage for rice improvement. Current study with 132 traditional rice cultivars had been collected from West Bengal, Manipur and Assam. Those cultivars are being preserved at repository of Uttar Banga Krishi Viswavidyalaya since 2009. Few of them had used in breeding programme to develop new desirable variety with unique characteristics. Those traditional cultivars were phenotypically characterized using PPV&FRA descriptor. In this piece of work, 44 traits were considered to record the morphological differences among the traditional cultivars. All the traditional cultivars showed one or few distinctive features that made different from each other. Finally the traditional cultivars were classified based few anticipated distinctive characters. Amylose content in endosperm was very low in ten, low in twelve, medium in 61 and high in 49 traditional cultivars. Amylose content of milled rice is a significant parameter in respect of consumer preference. Under Indian context, consumers prefer rice with medium amylose content (20-25%) in the endosperm. Strong aroma was emitted by 25, mild aroma by 23 and no aroma in 84 cultivar

The COVID‐19 Pandemic Not Only Poses Challenges, but Also Opens Opportunities for Sustainable Transformation

The COVID-19 pandemic has impacted social, economic, and environmental systems worldwide, slowing down and reversing the progress made in achieving the Sustainable Development Goals (SDGs). SDGs belong to the 2030 Agenda to transform our world by tackling humankind's challenges to ensure well-being, economic prosperity, and environmental protection. We explore the potential impacts of the pandemic on SDGs for Nepal. We followed a knowledge co-creation process with experts from various professional backgrounds, involving five steps: online survey, online workshop, assessment of expert's opinions, review and validation, and revision and synthesis. The pandemic has negatively impacted most SDGs in the short term. Particularly, the targets of SDG 1, 4, 5, 8, 9, 10, 11, and 13 have and will continue to have weakly to moderately restricting impacts. However, a few targets of SDG 2, 3, 6, and 11 could also have weakly promoting impacts. The negative impacts have resulted from impeding factors linked to the pandemic. Many of the negative impacts may subside in the medium and long terms. The key five impeding factors are lockdowns, underemployment and unemployment, closure of institutions and facilities, diluted focus and funds for non-COVID-19-related issues, and anticipated reduction in support from development partners. The pandemic has also opened a window of opportunity for sustainable transformation, which is short-lived and narrow. These opportunities are lessons learned for planning and action, socio-economic recovery plan, use of information and communication technologies and the digital economy, reverse migration and “brain gain,” and local governments' exercising authorities

Thermodynamic model for hydrothermal sulfide deposition in the paleoproterozoic granite ore system at Malanjkhand, India

1697-1711Malanjkhand fossil hydrothermal deposit is a Paleoproterozoic metallogeny associated with the Malanjkhand Granitoid represents an ideal granite ore system. It is formed by mixing of two distinct compositions of hydrothermal fluids in variable proportion derived from two different sources and results in the deposition of primary sulfide ores which comprises of chalcopyrite + pyrite ± bornite. Primary sulfide ores alters to secondary sulfides (chalcocite + chovellite) and oxides (cuprite + tenorite) ores because of extensive hydrothermal activities. Occurrence of two distinct varieties of ore assemblages (primary and secondary ores) indicates broadly two stages of sulfide deposition. Thermodynamic modeling suggests that hydrothermal alteration brings change in the physico-chemical environment from reduced to oxidized zone in the Malanjkhand granite ore system. The primary sulfide ores occurs in reduction zone whereas secondary ores found in the oxidation zone which forms of a cap on the primary ores. Change in the physico-chemical environment caused change in the composition of the ore minerals which favors enrichment in Cu along with the depletion of Fe and S content