Nicotine and smoking do not decrease basal gastric mucosal blood flow in anesthetized rats

The literature regarding the effect of nicotine and cigarette smoke on gastric blood flow is conflicting. The hydrogen gas clearance technique was used to measure the effects of nicotine and cigarette smoke on basal gastric mucosal blood flow in anesthetized rats. Blood flow was measured before, during, and after treatment with either intravenous nicotine (4 or 40 μg/kg/min) or inhaled cigarette smoke (nicotine or nicotine free). Neither intravenous nicotine nor cigarette smoke significantly altered gastric mucosal blood flow. On the other hand, hypotension produced by hemorrhage significantly decreased mucosal blood flow ( P <0.05). Thus the technique used could detect a decrease in blood flow. These findings indicate that in the anesthetized rats, hypotension but not intravenous nicotine or cigarette smoke, in the doses given, reduce gastric mucosal blood flow.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44399/1/10620_2005_Article_BF01320320.pd

Application of dehydroabietic acid in palladium-catalysed enyne cycloisomerisation

YesDehydroabietic acid (DAA) promotes palladium(0)‐catalysed cyclisations of arene‐tethered 1,7‐enynols and 1,m‐enynoates (m=6,7) to give fused carbocyclic dienes. 6,6,6,5‐Tetracyclic lactones are accessible by one‐pot cycloisomerisation/Diels–Alder reaction/lactonisation from 1,7‐enynols. Furthermore, asymmetric counteranion‐directed catalysis has been developed, which afforded an indene derivative with an all‐carbon quaternary stereogenic center.NSFC. Grant Number: 21462004 State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources. Grant Number: CMEMR2014A04 2015 GXNSFBA. Grant Number: 139032 GXN

Mass Spectrometric Investigations of Phenylacetic Acid Derivatives, III: Fragmentation of meta- and para-substituted Phenylacetamides after Electron Impact

The electron impact induced fragmentations of m- and p-substituted phenylacetamides and N,N-dimethyl-phenylacetamides 1-14 were investigated and compared with the o-analogues. A l l m- and p-substituted amides yield molecular ions with high relative intensities which do not lose their meta- and para-substituents. Loss of HNCO from M + * is dominant in the prim, amides, whilst for the tert. amides the classical benzyl cleavage is the most favourable fragmentation pathway. Die Elektronenstoß-induzierten Fragmentierungen der m- und p-substituierten Phenylacetamide bzw. N,N-Dimethyl-phenylacetamide 1-14 wurden untersucht und mit dem Verhalten ihrer o-substituierten Analogen verglichen. Alle m- und p-substituierten Amide zeigen M + ' mit hoher relat. Intensität und spalten die m- bzw. p-Substituenten nicht ab. Die prim. Amide verlieren bevorzugt H N C O aus M + " , während in den tert. Amiden klassische Benzylspaltung vorherrscht