Interpretation and expectations among mothers of children with anxiety disorders: associations with maternal anxiety disorder

Background Models of the development and maintenance of childhood anxiety suggest an important role for parent cognitions: that is, negative expectations of children's coping abilities lead to parenting behaviors that maintain child anxiety. The primary aims of the current study were to (1) compare expectations of child vulnerability and coping among mothers of children with anxiety disorders on the basis of whether or not mothers also had a current anxiety disorder, and (2) examine the degree to which the association between maternal anxiety disorder status and child coping expectations was mediated by how mothers interpreted ambiguous material that referred to their own experience. Methods The association between interpretations of threat, negative emotion, and control was assessed using hypothetical ambiguous scenarios in a sample of 271 anxious and nonanxious mothers of 7- to 12-year-old children with an anxiety disorder. Mothers also rated their expectations when presented with real life challenge tasks. Results There was a significant association between maternal anxiety disorder status and negative expectations of child coping behaviors. Mothers’ self-referent interpretations were found to mediate this relationship. Responses to ambiguous hypothetical scenarios correlated significantly with responses to real life challenge tasks. Conclusions Treatments for childhood anxiety disorders in the context of parental anxiety disorders may benefit from the inclusion of a component to directly address parental cognitions. Some inconsistencies were found when comparing maternal expectations in response to hypothetical scenarios with real life challenges. This should be addressed in future research

Near-Infrared Spectroscopy of High Redshift Quasars: Bringing Distant Quasars into View

The Gemini Near Infrared Spectrograph - Distant Quasar Survey (GNIRS-DQS) is the largest uniform, homogeneous survey of its kind, covering 260 quasars at 1.5 ≤ z ≤ 3.5. This unique survey, coupled with data from the Sloan Digital Sky Survey (SDSS), enables new investigations into redshifts, supermassive black hole masses (MBH), and accretion rates at high redshift through spectroscopic coverage of important rest-frame UV-optical emission lines. The importance of this survey is highlighted in the fact that the optical emission lines provide more reliable measurements of these quasar parameters than their UV counterpart. With such a unique sample compiled here, I construct prescriptions to calibrate these quasar parameters derived from rest-frame UV emission lines to those derived from rest-frame optical emission lines. These prescriptions provide important insight into how these parameters depend on redshift and are potentially biased as we look out further into the universe. Additionally, all the work completed with this sample will help shape our understanding of how these quasars and their host galaxies co-evolve over cosmic time

Plasma Dynamics

Contains reports on three research projects.Wright Air Development Division (Contract AF33(616)-3984)United States Atomic Energy Commission (Contract AT(30-1)-1842)National Science Foundation (Grant G-9330)United States Air Force, Air Force Cambridge Research Center (Contract AF19(604)-4551)United States Air Force, Air Force Cambridge Research Center, Air Research and Development Command (Contract AF19(604)-5992

Effective interventions to increase representation of under-served groups in randomised trials in UK and Ireland: a scoping literature review [version 1; peer review: 1 approved]

Background Participants in clinical trials often do not reflect the populations that could benefit from the treatments being investigated. There are known barriers to trial participation for under-served groups, but limited evidence on strategies to alleviate these barriers to improve representation. This scoping review aimed to identify effective interventions and design features that improve the representation `of under-served groups in trials, focusing on the UK and Ireland. Methods We included methodological research studies that reported interventions to improve representation of ethnic minority groups, socioeconomically disadvantaged groups, older people, or those with impaired capacity to consent to randomised controlled trials, conducted in the UK and Ireland, published between 2000–2021. Systematic searches were conducted in November 2021 and data were independently extracted by two authors and narratively synthesised. Results Seven studies were included: one randomised controlled study embedded in five trials, one mixed-methods study, and five studies reporting ‘lessons learnt’ from one trial. We categorised the 47 reported interventions or strategies into nine broad themes: Recruitment sites, recruitment settings, community engagement, and communication with participants, incentives, inclusion criteria, flexibility, patient documentation, and the consent process. Only 28/47 interventions were evaluated, 23 of which were comparison of recruitment pathways. The randomised study found that a £100 incentive mentioned in the invitation letter increased positive responses overall across drug trials in cardiovascular disease and hypertension, but not for older people or those living in the most deprived areas. Invitation letters via GPs and working with communities were reported as successful recruitment pathways in recruiting different under-served populations. Conclusions Interventions aiming to improve the recruitment of under-served groups in the UK and Ireland were reported across seven papers, but their effectiveness was rarely rigorously evaluated. Included studies were context specific. Using a variety of recruitment methods is likely to help achieve a more diverse cohort

Can X-Ray Observations Improve Optical-UV-based Accretion-rate Estimates for Quasars?

Article presents a study utilizing a carefully selected sample of 53 radio-quiet quasars that have Hβ and C iv λ1549 spectroscopy as well as Chandra coverage, to search for a robust accretion-rate indicator for quasars, particularly at the highest-accessible redshifts (z ∼ 6–7)

Observing interactions between children and adolescents and their parents: the effects of anxiety disorder and age

Parental behaviors, most notably overcontrol, lack of warmth and expressed anxiety, have been implicated in models of the development and maintenance of anxiety disorders in children and young people. Theories of normative development have proposed that different parental responses are required to support emotional development in childhood and adolescence, yet age has not typically been taken into account in studies of parenting and anxiety disorders. In order to identify whether associations between anxiety disorder status and parenting differ in children and adolescents, we compared observed behaviors of parents of children (7–10 years) and adolescents (13–16 years) with and without anxiety disorders (n=120), while they undertook a series of mildly anxiety-provoking tasks. Parents of adolescents showed significantly lower levels of expressed anxiety, intrusiveness and warm engagement than parents of children. Furthermore, offspring age moderated the association between anxiety disorder status and parenting behaviors. Specifically, parents of adolescents with anxiety disorders showed higher intrusiveness and lower warm engagement than parents of non-anxious adolescents. A similar relationship between these parenting behaviors and anxiety disorder status was not observed among parents of children. The findings suggest that theoretical accounts of the role of parental behaviors in anxiety disorders in children and adolescents should distinguish between these different developmental periods. Further experimental research to establish causality, however, would be required before committing additional resources to targeting parenting factors within treatment

Gemini Near Infrared Spectrograph - Distant Quasar Survey: Prescriptions for Calibrating UV-Based Estimates of Supermassive Black Hole Masses in High-Redshift Quasars

The most reliable single-epoch supermassive black hole mass ($M_{\rm BH}$) estimates in quasars are obtained by using the velocity widths of low-ionization emission lines, typically the H$\beta$ $\lambda4861$ line. Unfortunately, this line is redshifted out of the optical band at $z\approx1$, leaving $M_{\rm BH}$ estimates to rely on proxy rest-frame ultraviolet (UV) emission lines, such as C IV $\lambda1549$ or Mg II $\lambda2800$, which contain intrinsic challenges when measuring, resulting in uncertain $M_{\rm BH}$ estimates. In this work, we aim at correcting $M_{\rm BH}$ estimates derived from the C IV and Mg II emission lines based on estimates derived from the H$\beta$ emission line. We find that employing the equivalent width of C IV in deriving $M_{\rm BH}$ estimates based on Mg II and C IV provides values that are closest to those obtained from H$\beta$. We also provide prescriptions to estimate $M_{\rm BH}$ values when only C IV, only Mg II, and both C IV and Mg II are measurable. We find that utilizing both emission lines, where available, reduces the scatter of UV-based $M_{\rm BH}$ estimates by $\sim15\%$ when compared to previous studies. Lastly, we discuss the potential of our prescriptions to provide more accurate and precise estimates of $M_{\rm BH}$ given a much larger sample of quasars at $3.20 \lesssim z \lesssim 3.50$, where both Mg II and H$\beta$ can be measured in the same near-infrared spectrum.Comment: 19 pages (AASTeX 6.3.1), 9 figures, accepted for publication in Ap

Author Correction: Rapidly-migrating and internally-generated knickpoints can control submarine channel evolution (Nature Communications, (2020), 11, 1, (3129), 10.1038/s41467-020-16861-x)

© 2020, The Author(s). The original version of this Article contained an error in the labelling of the cross-section in Fig. 2g and the vertical axis in Fig. 2b. This has been corrected in both the PDF and HTML versions of the Article

Effective interventions to increase representation of under-served groups in randomised trials in UK and Ireland: a scoping literature review [version 1; peer review: awaiting peer review]

Background: Participants in clinical trials often do not reflect the populations that could benefit from the treatments being investigated. There are known barriers to trial participation for under-served groups, but limited evidence on strategies to alleviate these barriers to improve representation. This scoping review aimed to identify effective interventions and design features that improve the representation `of under-served groups in trials, focusing on the UK and Ireland. Methods: We included methodological research studies that reported interventions to improve representation of ethnic minority groups, socioeconomically disadvantaged groups, older people, or those with impaired capacity to consent to randomised controlled trials, conducted in the UK and Ireland, published between 2000–2021. Systematic searches were conducted in November 2021 and data were independently extracted by two authors and narratively synthesised. Results: Seven studies were included: one randomised controlled study embedded in five trials, one mixed-methods study, and five studies reporting ‘lessons learnt’ from one trial. We categorised the 47 reported interventions or strategies into nine broad themes: Recruitment sites, recruitment settings, community engagement, and communication with participants, incentives, inclusion criteria, flexibility, patient documentation, and the consent process. Only 28/47 interventions were evaluated, 23 of which were comparison of recruitment pathways. The randomised study found that a £100 incentive mentioned in the invitation letter increased positive responses overall across drug trials in cardiovascular disease and hypertension, but not for older people or those living in the most deprived areas. Invitation letters via GPs and working with communities were reported as successful recruitment pathways in recruiting different under-served populations. Conclusions: Interventions aiming to improve the recruitment of under-served groups in the UK and Ireland were reported across seven papers, but their effectiveness was rarely rigorously evaluated. Included studies were context specific. Using a variety of recruitment methods is likely to help achieve a more diverse cohort

Effective interventions to increase representation of under-served groups in randomised trials in UK and Ireland: a scoping literature review

Background Participants in clinical trials often do not reflect the populations that could benefit from the treatments being investigated. There are known barriers to trial participation for under-served groups, but limited evidence on strategies to alleviate these barriers to improve representation. This scoping review aimed to identify effective interventions and design features that improve the representation `of under-served groups in trials, focusing on the UK and Ireland. Methods We included methodological research studies that reported interventions to improve representation of ethnic minority groups, socioeconomically disadvantaged groups, older people, or those with impaired capacity to consent to randomised controlled trials, conducted in the UK and Ireland, published between 2000–2021. Systematic searches were conducted in November 2021 and data were independently extracted by two authors and narratively synthesised. Results Seven studies were included: one randomised controlled study embedded in five trials, one mixed-methods study, and five studies reporting ‘lessons learnt’ from one trial. We categorised the 47 reported interventions or strategies into nine broad themes: Recruitment sites, recruitment settings, community engagement, and communication with participants, incentives, inclusion criteria, flexibility, patient documentation, and the consent process. Only 28/47 interventions were evaluated, 23 of which were comparison of recruitment pathways. The randomised study found that a £100 incentive mentioned in the invitation letter increased positive responses overall across drug trials in cardiovascular disease and hypertension, but not for older people or those living in the most deprived areas. Invitation letters via GPs and working with communities were reported as successful recruitment pathways in recruiting different under-served populations. Conclusions Interventions aiming to improve the recruitment of under-served groups in the UK and Ireland were reported across seven papers, but their effectiveness was rarely rigorously evaluated. Included studies were context specific. Using a variety of recruitment methods is likely to help achieve a more diverse cohort